Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI38_RS03380 | Genome accession | NZ_CP064545 |
| Coordinates | 688737..689312 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG365 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 689713..732291 | 688737..689312 | flank | 401 |
Gene organization within MGE regions
Location: 688737..732291
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI38_RS03380 (HWI38_03335) | comK/comK1 | 688737..689312 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI38_RS03395 (HWI38_03350) | - | 689713..690762 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI38_RS03400 (HWI38_03355) | - | 690873..691070 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI38_RS03405 (HWI38_03360) | - | 691067..691474 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI38_RS03410 (HWI38_03365) | - | 691468..691905 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI38_RS03415 (HWI38_03370) | - | 692017..692685 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI38_RS03420 (HWI38_03375) | - | 692703..693161 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI38_RS03425 (HWI38_03380) | - | 693183..693497 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI38_RS03430 (HWI38_03385) | - | 693650..693862 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI38_RS03435 (HWI38_03390) | - | 693906..694046 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI38_RS03440 (HWI38_03395) | - | 694039..694263 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI38_RS03445 (HWI38_03400) | - | 694313..695053 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI38_RS03450 (HWI38_03405) | - | 695066..695275 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI38_RS03455 (HWI38_03410) | - | 695289..695435 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI38_RS03460 (HWI38_03415) | - | 695422..695700 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI38_RS03465 (HWI38_03420) | - | 695795..695971 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI38_RS03470 (HWI38_03425) | - | 696033..696284 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI38_RS03475 (HWI38_03430) | - | 696277..696762 (+) | 486 | WP_407568374.1 | siphovirus Gp157 family protein | - |
| HWI38_RS03480 (HWI38_03435) | - | 696763..697389 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI38_RS03485 (HWI38_03440) | - | 697382..697798 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI38_RS03490 (HWI38_03445) | - | 697812..698501 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI38_RS03495 (HWI38_03450) | - | 698479..698709 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI38_RS03500 (HWI38_03455) | - | 698715..698930 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI38_RS03505 (HWI38_03460) | - | 698917..699645 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI38_RS03510 (HWI38_03465) | - | 699651..700004 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI38_RS03515 (HWI38_03470) | - | 699994..701241 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI38_RS03520 (HWI38_03475) | - | 701238..701468 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI38_RS03525 (HWI38_03480) | - | 701437..701661 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI38_RS03530 (HWI38_03485) | - | 701672..702088 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI38_RS03535 (HWI38_03490) | - | 702075..702449 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI38_RS03540 (HWI38_03495) | - | 702449..702640 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI38_RS03545 (HWI38_03500) | - | 702641..703000 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI38_RS03550 (HWI38_03505) | - | 702997..703449 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI38_RS03555 (HWI38_03510) | - | 703439..703726 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI38_RS03560 (HWI38_03515) | - | 703742..704422 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI38_RS03565 (HWI38_03520) | - | 704419..704619 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI38_RS03570 (HWI38_03525) | - | 704603..704956 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI38_RS03575 (HWI38_03530) | - | 704937..705134 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI38_RS03580 (HWI38_03535) | - | 705135..705662 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI38_RS03585 (HWI38_03540) | - | 705824..705982 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI38_RS03590 (HWI38_03545) | - | 706041..706319 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI38_RS03595 (HWI38_03550) | rinB | 706312..706479 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI38_RS03600 (HWI38_03555) | - | 706479..706628 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI38_RS03605 (HWI38_03560) | - | 706645..707091 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI38_RS03610 (HWI38_03565) | - | 707686..708036 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI38_RS03615 (HWI38_03570) | - | 708179..708649 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI38_RS03620 (HWI38_03575) | - | 708642..710393 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI38_RS03625 (HWI38_03580) | - | 710405..710599 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI38_RS03630 (HWI38_03585) | - | 710602..711834 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI38_RS03635 (HWI38_03590) | - | 711824..712381 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI38_RS03640 (HWI38_03595) | - | 712421..713770 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI38_RS03645 (HWI38_03600) | - | 713789..714130 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI38_RS03650 (HWI38_03605) | - | 714120..714449 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI38_RS03655 (HWI38_03610) | - | 714563..714850 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI38_RS03660 (HWI38_03615) | - | 714853..715257 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI38_RS03665 (HWI38_03620) | - | 715270..715899 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI38_RS03670 (HWI38_03625) | - | 715918..716103 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI38_RS03675 (HWI38_03630) | gpG | 716167..716529 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI38_RS03680 | gpGT | 716562..716714 (+) | 153 | WP_153801570.1 | phage tail assembly chaperone GT | - |
| HWI38_RS03685 (HWI38_03635) | - | 716743..721299 (+) | 4557 | WP_002504771.1 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI38_RS03690 (HWI38_03640) | - | 721301..722134 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI38_RS03695 (HWI38_03645) | - | 722144..723703 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI38_RS03700 (HWI38_03650) | - | 723696..723869 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI38_RS03705 (HWI38_03655) | - | 723885..725747 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI38_RS03710 (HWI38_03660) | - | 725747..726961 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI38_RS03715 (HWI38_03665) | - | 726966..727589 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI38_RS03720 (HWI38_03670) | - | 727586..728011 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI38_RS03725 (HWI38_03675) | - | 727998..728405 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI38_RS03730 (HWI38_03680) | - | 728531..728797 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI38_RS03735 (HWI38_03685) | - | 728797..730179 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI38_RS03740 (HWI38_03690) | - | 730257..731183 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI38_RS03745 (HWI38_03695) | - | 731376..731903 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI38_RS03750 (HWI38_03700) | - | 731893..732291 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=502924 HWI38_RS03380 WP_001829272.1 688737..689312(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG365]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=502924 HWI38_RS03380 WP_001829272.1 688737..689312(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG365]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |