Detailed information NTG0502888

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI39_RS05540
• Genome accession: NZ_CP064543
• Coordinates: 1136103..1137149 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG366
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1131103..1142149

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI39_RS05515 (HWI39_05485)	isaB	1132244..1132780 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI39_RS05520 (HWI39_05490)	-	1132931..1133917 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
HWI39_RS05525 (HWI39_05495)	map	1134091..1134846 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI39_RS05530 (HWI39_05500)	-	1135004..1135390 (+)	387	WP_001830382.1	hypothetical protein	-
HWI39_RS05535 (HWI39_05505)	liaF	1135405..1136106 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
HWI39_RS05540 (HWI39_05510)	vraS	1136103..1137149 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI39_RS05545 (HWI39_05515)	vraR	1137139..1137768 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI39_RS05550 (HWI39_05520)	-	1137825..1139003 (-)	1179	WP_346415522.1	YihY/virulence factor BrkB family protein	-
HWI39_RS05555 (HWI39_05525)	-	1139410..1139694 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI39_RS05560 (HWI39_05530)	-	1139702..1140166 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI39_RS05565 (HWI39_05535)	-	1140307..1140522 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI39_RS05570 (HWI39_05540)	-	1140524..1141765 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502888 HWI39_RS05540 WP_001830374.1 1136103..1137149(+) (vraS) [Staphylococcus epidermidis strain UMCG366]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502888 HWI39_RS05540 WP_001830374.1 1136103..1137149(+) (vraS) [Staphylococcus epidermidis strain UMCG366]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92