Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HWI40_RS04300 Genome accession   NZ_CP064540
Coordinates   917172..917801 (+) Length   209 a.a.
NCBI ID   WP_001830439.1    Uniprot ID   A0A2G7HYX3
Organism   Staphylococcus epidermidis strain UMCG367     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 912172..922801
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI40_RS04270 (HWI40_04230) isaB 912277..912813 (+) 537 WP_001830372.1 immunodominant staphylococcal antigen IsaB family protein -
  HWI40_RS04275 (HWI40_04235) - 912964..913950 (-) 987 WP_001830388.1 aromatic acid exporter family protein -
  HWI40_RS04280 (HWI40_04240) map 914124..914879 (+) 756 WP_001830397.1 type I methionyl aminopeptidase -
  HWI40_RS04285 (HWI40_04245) - 915037..915423 (+) 387 WP_001830382.1 hypothetical protein -
  HWI40_RS04290 (HWI40_04250) liaF 915438..916139 (+) 702 WP_001830436.1 cell wall-active antibiotics response protein LiaF -
  HWI40_RS04295 (HWI40_04255) vraS 916136..917182 (+) 1047 WP_001830374.1 sensor histidine kinase Regulator
  HWI40_RS04300 (HWI40_04260) vraR 917172..917801 (+) 630 WP_001830439.1 two-component system response regulator VraR Regulator
  HWI40_RS04305 (HWI40_04265) - 917858..919036 (-) 1179 WP_001830411.1 YihY/virulence factor BrkB family protein -
  HWI40_RS04310 (HWI40_04270) - 919443..919727 (-) 285 WP_001830401.1 YtxH domain-containing protein -
  HWI40_RS04315 (HWI40_04275) - 919735..920199 (-) 465 WP_001830437.1 low molecular weight protein-tyrosine-phosphatase -
  HWI40_RS04320 (HWI40_04280) - 920340..920555 (+) 216 WP_001830421.1 DUF1128 domain-containing protein -
  HWI40_RS04325 (HWI40_04285) - 920557..921798 (+) 1242 WP_001832467.1 aminopeptidase -
  HWI40_RS04330 (HWI40_04290) - 921878..922408 (+) 531 WP_001830371.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23584.19 Da        Isoelectric Point: 4.7166

>NTDB_id=502853 HWI40_RS04300 WP_001830439.1 917172..917801(+) (vraR) [Staphylococcus epidermidis strain UMCG367]
MAIKVLFVDDHEMVRIGISSYLSTQEDIEVVGEGASGKDAITKAHELKPDLILMDLLMDDMDGVEATTEIKKDLPQIKVV
MLTSFIEDKEVYRALDSGVDSYILKTTSASDIADAVRKTYEGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=502853 HWI40_RS04300 WP_001830439.1 917172..917801(+) (vraR) [Staphylococcus epidermidis strain UMCG367]
GTGGCGATTAAAGTTTTATTTGTTGATGATCATGAAATGGTAAGAATCGGTATTTCAAGCTATCTTTCAACTCAAGAAGA
TATAGAAGTAGTAGGTGAGGGTGCTTCTGGTAAAGATGCTATCACTAAAGCGCATGAGCTAAAACCAGATTTAATATTAA
TGGATTTACTTATGGACGATATGGATGGTGTAGAAGCAACTACTGAAATAAAAAAAGATTTACCTCAAATTAAAGTAGTC
ATGTTAACAAGCTTTATAGAGGATAAAGAAGTTTATCGTGCACTTGATTCTGGAGTAGATAGTTATATTTTAAAGACAAC
AAGTGCAAGTGATATAGCTGACGCTGTGCGTAAAACGTATGAAGGTGAATCAGTATTTGAACCAGAAGTGTTAGTAAAAA
TGCGCAATCGTATGAAAAAACGTGCCGAGCTTTATGAAATGTTGACAGAAAGAGAAATGGAGATCCTATTACTTATAGCT
AAAGGATACTCTAACCAAGAGATTGCAAGCGCCTCTCATATCACCATCAAAACAGTAAAAACTCATGTAAGTAACATACT
AAGTAAATTAGAAGTACAAGATCGAACACAAGCAGTAATATATGCGTTCCAGCATAATTTAATTCAATAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2G7HYX3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

94.737

100

0.947
  degU Bacillus subtilis subsp. subtilis str. 168

34.375

100

0.368