Detailed information NTG0502632

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI46_RS04555
• Genome accession: NZ_CP064519
• Coordinates: 968064..969110 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG373
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 963064..974110

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI46_RS04530 (HWI46_04485)	isaB	964205..964741 (+)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI46_RS04535 (HWI46_04490)	-	964892..965878 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
HWI46_RS04540 (HWI46_04495)	map	966052..966807 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI46_RS04545 (HWI46_04500)	-	966965..967351 (+)	387	WP_001830382.1	hypothetical protein	-
HWI46_RS04550 (HWI46_04505)	liaF	967366..968067 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
HWI46_RS04555 (HWI46_04510)	vraS	968064..969110 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI46_RS04560 (HWI46_04515)	vraR	969100..969729 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI46_RS04565 (HWI46_04520)	-	969786..970964 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI46_RS04570 (HWI46_04525)	-	971371..971655 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI46_RS04575 (HWI46_04530)	-	971663..972127 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI46_RS04580 (HWI46_04535)	-	972268..972483 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI46_RS04585 (HWI46_04540)	-	972485..973726 (+)	1242	WP_002457094.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=502632 HWI46_RS04555 WP_001830374.1 968064..969110(+) (vraS) [Staphylococcus epidermidis strain UMCG373]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=502632 HWI46_RS04555 WP_001830374.1 968064..969110(+) (vraS) [Staphylococcus epidermidis strain UMCG373]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92