Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HWI59_RS04620 Genome accession   NZ_CP064471
Coordinates   987653..988282 (+) Length   209 a.a.
NCBI ID   WP_002473914.1    Uniprot ID   -
Organism   Staphylococcus epidermidis strain UMCG387     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 982653..993282
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI59_RS04590 (HWI59_04545) isaB 982757..983293 (+) 537 WP_002447446.1 immunodominant staphylococcal antigen IsaB family protein -
  HWI59_RS04595 (HWI59_04550) - 983445..984431 (-) 987 WP_002447445.1 aromatic acid exporter family protein -
  HWI59_RS04600 (HWI59_04555) map 984605..985360 (+) 756 WP_002447444.1 type I methionyl aminopeptidase -
  HWI59_RS04605 (HWI59_04560) - 985518..985904 (+) 387 WP_002495657.1 hypothetical protein -
  HWI59_RS04610 (HWI59_04565) liaF 985919..986620 (+) 702 WP_002447442.1 cell wall-active antibiotics response protein LiaF -
  HWI59_RS04615 (HWI59_04570) vraS 986617..987663 (+) 1047 WP_002447441.1 sensor histidine kinase Regulator
  HWI59_RS04620 (HWI59_04575) vraR 987653..988282 (+) 630 WP_002473914.1 two-component system response regulator VraR Regulator
  HWI59_RS04625 (HWI59_04580) - 988339..989517 (-) 1179 WP_408020721.1 YihY/virulence factor BrkB family protein -
  HWI59_RS04630 (HWI59_04585) - 989923..990207 (-) 285 WP_002447438.1 YtxH domain-containing protein -
  HWI59_RS04635 (HWI59_04590) - 990215..990679 (-) 465 WP_070593291.1 low molecular weight protein-tyrosine-phosphatase -
  HWI59_RS04640 (HWI59_04595) - 990821..991036 (+) 216 WP_001830421.1 DUF1128 domain-containing protein -
  HWI59_RS04645 (HWI59_04600) - 991038..992279 (+) 1242 WP_002458545.1 aminopeptidase -
  HWI59_RS04650 (HWI59_04605) - 992360..992890 (+) 531 WP_002447436.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23598.22 Da        Isoelectric Point: 4.7218

>NTDB_id=502157 HWI59_RS04620 WP_002473914.1 987653..988282(+) (vraR) [Staphylococcus epidermidis strain UMCG387]
MAIKVLFVDDHEMVRIGISSYLSTQEDIEVVGEGASGKEAITKAHELKPDLILMDLLMDDMDGVEATTEIKKDLPQIKVV
MLTSFIEDKEVYRALDSGVDSYILKTTSASDIADAVRKTYEGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=502157 HWI59_RS04620 WP_002473914.1 987653..988282(+) (vraR) [Staphylococcus epidermidis strain UMCG387]
GTGGCGATTAAAGTTTTATTTGTTGATGATCATGAAATGGTAAGAATCGGTATTTCAAGCTATCTTTCAACACAAGAAGA
TATAGAAGTAGTAGGTGAGGGTGCTTCTGGTAAGGAGGCTATCACTAAAGCGCATGAGCTAAAACCAGATTTAATTTTAA
TGGATTTACTTATGGACGATATGGATGGTGTAGAAGCTACTACTGAAATAAAAAAAGATTTACCTCAAATTAAAGTAGTC
ATGTTAACAAGCTTTATAGAAGATAAAGAAGTTTATCGTGCACTTGATTCTGGAGTAGATAGTTATATTTTAAAGACAAC
AAGTGCAAGTGATATAGCTGACGCTGTGCGTAAAACGTATGAAGGTGAATCAGTATTTGAACCAGAAGTGTTAGTAAAAA
TGCGCAACCGTATGAAAAAACGTGCCGAGCTTTATGAAATGTTAACAGAAAGAGAAATGGAGATCTTATTACTTATAGCT
AAAGGATACTCTAACCAAGAGATTGCAAGCGCCTCTCATATCACCATCAAAACAGTAAAAACTCATGTAAGTAACATACT
GAGTAAATTAGAAGTACAAGATCGAACACAAGCAGTAATCTATGCGTTTCAGCATAATTTAATTCAATAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

95.215

100

0.952
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373