Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI61_RS03380 | Genome accession | NZ_CP064467 |
| Coordinates | 688792..689367 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG389 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 689768..732346 | 688792..689367 | flank | 401 |
Gene organization within MGE regions
Location: 688792..732346
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI61_RS03380 (HWI61_03340) | comK/comK1 | 688792..689367 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI61_RS03395 (HWI61_03355) | - | 689768..690817 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI61_RS03400 (HWI61_03360) | - | 690928..691125 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI61_RS03405 (HWI61_03365) | - | 691122..691529 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI61_RS03410 (HWI61_03370) | - | 691523..691960 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI61_RS03415 (HWI61_03375) | - | 692072..692740 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI61_RS03420 (HWI61_03380) | - | 692758..693216 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI61_RS03425 (HWI61_03385) | - | 693238..693552 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI61_RS03430 (HWI61_03390) | - | 693705..693917 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI61_RS03435 (HWI61_03395) | - | 693961..694101 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI61_RS03440 (HWI61_03400) | - | 694094..694318 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI61_RS03445 (HWI61_03405) | - | 694368..695108 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI61_RS03450 (HWI61_03410) | - | 695121..695330 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI61_RS03455 (HWI61_03415) | - | 695344..695490 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI61_RS03460 (HWI61_03420) | - | 695477..695755 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI61_RS03465 (HWI61_03425) | - | 695850..696026 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI61_RS03470 (HWI61_03430) | - | 696088..696339 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI61_RS03475 (HWI61_03435) | - | 696332..696817 (+) | 486 | WP_407568374.1 | siphovirus Gp157 family protein | - |
| HWI61_RS03480 (HWI61_03440) | - | 696818..697444 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI61_RS03485 (HWI61_03445) | - | 697437..697853 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI61_RS03490 (HWI61_03450) | - | 697867..698556 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI61_RS03495 (HWI61_03455) | - | 698534..698764 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI61_RS03500 (HWI61_03460) | - | 698770..698985 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI61_RS03505 (HWI61_03465) | - | 698972..699700 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI61_RS03510 (HWI61_03470) | - | 699706..700059 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI61_RS03515 (HWI61_03475) | - | 700049..701296 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI61_RS03520 (HWI61_03480) | - | 701293..701523 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI61_RS03525 (HWI61_03485) | - | 701492..701716 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI61_RS03530 (HWI61_03490) | - | 701727..702143 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI61_RS03535 (HWI61_03495) | - | 702130..702504 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI61_RS03540 (HWI61_03500) | - | 702504..702695 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI61_RS03545 (HWI61_03505) | - | 702696..703055 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI61_RS03550 (HWI61_03510) | - | 703052..703504 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI61_RS03555 (HWI61_03515) | - | 703494..703781 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI61_RS03560 (HWI61_03520) | - | 703797..704477 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI61_RS03565 (HWI61_03525) | - | 704474..704674 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI61_RS03570 (HWI61_03530) | - | 704658..705011 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI61_RS03575 (HWI61_03535) | - | 704992..705189 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI61_RS03580 (HWI61_03540) | - | 705190..705717 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI61_RS03585 (HWI61_03545) | - | 705879..706037 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI61_RS03590 (HWI61_03550) | - | 706096..706374 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI61_RS03595 (HWI61_03555) | rinB | 706367..706534 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI61_RS03600 (HWI61_03560) | - | 706534..706683 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI61_RS03605 (HWI61_03565) | - | 706700..707146 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI61_RS03610 (HWI61_03570) | - | 707741..708091 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI61_RS03615 (HWI61_03575) | - | 708234..708704 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI61_RS03620 (HWI61_03580) | - | 708697..710448 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI61_RS03625 (HWI61_03585) | - | 710460..710654 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI61_RS03630 (HWI61_03590) | - | 710657..711889 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI61_RS03635 (HWI61_03595) | - | 711879..712436 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI61_RS03640 (HWI61_03600) | - | 712476..713825 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI61_RS03645 (HWI61_03605) | - | 713844..714185 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI61_RS03650 (HWI61_03610) | - | 714175..714504 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI61_RS03655 (HWI61_03615) | - | 714618..714905 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI61_RS03660 (HWI61_03620) | - | 714908..715312 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI61_RS03665 (HWI61_03625) | - | 715325..715954 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI61_RS03670 (HWI61_03630) | - | 715973..716158 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI61_RS03675 (HWI61_03635) | gpG | 716222..716584 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI61_RS03680 (HWI61_03640) | gpGT | 716629..716769 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI61_RS03685 (HWI61_03645) | - | 716798..721354 (+) | 4557 | WP_002504771.1 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI61_RS03690 (HWI61_03650) | - | 721356..722189 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI61_RS03695 (HWI61_03655) | - | 722199..723758 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI61_RS03700 (HWI61_03660) | - | 723751..723924 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI61_RS03705 (HWI61_03665) | - | 723940..725802 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI61_RS03710 (HWI61_03670) | - | 725802..727016 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI61_RS03715 (HWI61_03675) | - | 727021..727644 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI61_RS03720 (HWI61_03680) | - | 727641..728066 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI61_RS03725 (HWI61_03685) | - | 728053..728460 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI61_RS03730 (HWI61_03690) | - | 728586..728852 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI61_RS03735 (HWI61_03695) | - | 728852..730234 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI61_RS03740 (HWI61_03700) | - | 730312..731238 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI61_RS03745 (HWI61_03705) | - | 731431..731958 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI61_RS03750 (HWI61_03710) | - | 731948..732346 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=502118 HWI61_RS03380 WP_001829272.1 688792..689367(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG389]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=502118 HWI61_RS03380 WP_001829272.1 688792..689367(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG389]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |