Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HWI65_RS04595 Genome accession   NZ_CP064453
Coordinates   990251..990880 (+) Length   209 a.a.
NCBI ID   WP_001830439.1    Uniprot ID   A0A2G7HYX3
Organism   Staphylococcus epidermidis strain UMCG335     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 985251..995880
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI65_RS04565 (HWI65_04545) isaB 985356..985892 (+) 537 WP_001830372.1 immunodominant staphylococcal antigen IsaB family protein -
  HWI65_RS04570 (HWI65_04550) - 986043..987029 (-) 987 WP_002457091.1 aromatic acid exporter family protein -
  HWI65_RS04575 (HWI65_04555) map 987203..987958 (+) 756 WP_002457092.1 type I methionyl aminopeptidase -
  HWI65_RS04580 (HWI65_04560) - 988116..988502 (+) 387 WP_001830382.1 hypothetical protein -
  HWI65_RS04585 (HWI65_04565) liaF 988517..989218 (+) 702 WP_002457093.1 cell wall-active antibiotics response protein LiaF -
  HWI65_RS04590 (HWI65_04570) vraS 989215..990261 (+) 1047 WP_002486322.1 sensor histidine kinase Regulator
  HWI65_RS04595 (HWI65_04575) vraR 990251..990880 (+) 630 WP_001830439.1 two-component system response regulator VraR Regulator
  HWI65_RS04600 (HWI65_04580) - 990937..992115 (-) 1179 WP_001830411.1 YihY/virulence factor BrkB family protein -
  HWI65_RS04605 (HWI65_04585) - 992522..992806 (-) 285 WP_001830401.1 YtxH domain-containing protein -
  HWI65_RS04610 (HWI65_04590) - 992814..993278 (-) 465 WP_001830437.1 low molecular weight protein-tyrosine-phosphatase -
  HWI65_RS04615 (HWI65_04595) - 993419..993634 (+) 216 WP_001830421.1 DUF1128 domain-containing protein -
  HWI65_RS04620 (HWI65_04600) - 993636..994877 (+) 1242 WP_002457094.1 aminopeptidase -
  HWI65_RS04625 (HWI65_04605) - 994957..995487 (+) 531 WP_001830371.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23584.19 Da        Isoelectric Point: 4.7166

>NTDB_id=501970 HWI65_RS04595 WP_001830439.1 990251..990880(+) (vraR) [Staphylococcus epidermidis strain UMCG335]
MAIKVLFVDDHEMVRIGISSYLSTQEDIEVVGEGASGKDAITKAHELKPDLILMDLLMDDMDGVEATTEIKKDLPQIKVV
MLTSFIEDKEVYRALDSGVDSYILKTTSASDIADAVRKTYEGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=501970 HWI65_RS04595 WP_001830439.1 990251..990880(+) (vraR) [Staphylococcus epidermidis strain UMCG335]
GTGGCGATTAAAGTTTTATTTGTTGATGATCATGAAATGGTAAGAATCGGTATTTCAAGCTATCTTTCAACTCAAGAAGA
TATAGAAGTAGTAGGTGAGGGTGCTTCTGGTAAAGATGCTATCACTAAAGCGCATGAGCTAAAACCAGATTTAATATTAA
TGGATTTACTTATGGACGATATGGATGGTGTAGAAGCAACTACTGAAATAAAAAAAGATTTACCTCAAATTAAAGTAGTC
ATGTTAACAAGCTTTATAGAGGATAAAGAAGTTTATCGTGCACTTGATTCTGGAGTAGATAGTTATATTTTAAAGACAAC
AAGTGCAAGTGATATAGCTGACGCTGTGCGTAAAACGTATGAAGGTGAATCAGTATTTGAACCAGAAGTGTTAGTAAAAA
TGCGCAATCGTATGAAAAAACGTGCCGAGCTTTATGAAATGTTGACAGAAAGAGAAATGGAGATCCTATTACTTATAGCT
AAAGGATACTCTAACCAAGAGATTGCAAGCGCCTCTCATATCACCATCAAAACAGTAAAAACTCATGTAAGTAACATACT
AAGTAAATTAGAAGTACAAGATCGAACACAAGCAGTAATATATGCGTTCCAGCATAATTTAATTCAATAA

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2G7HYX3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

94.737

100

0.947
  degU Bacillus subtilis subsp. subtilis str. 168

34.375

100

0.368