Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   JKN67_RS10845 Genome accession   NZ_CP076237
Coordinates   2174258..2174914 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O157:H7 strain 146N4     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2169258..2179914
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JKN67_RS10815 (JKN67_10760) dcyD 2170137..2171123 (+) 987 WP_001128225.1 D-cysteine desulfhydrase -
  JKN67_RS10820 (JKN67_10765) tcyL 2171138..2171806 (+) 669 WP_001158226.1 cystine ABC transporter permease -
  JKN67_RS10825 (JKN67_10770) tcyN 2171803..2172555 (+) 753 WP_001273005.1 L-cystine ABC transporter ATP-binding protein TcyN -
  JKN67_RS10830 (JKN67_10775) sdiA 2172785..2173507 (+) 723 WP_001154288.1 transcriptional regulator SdiA -
  JKN67_RS10835 (JKN67_10780) yecF 2173575..2173799 (-) 225 WP_000106479.1 DUF2594 family protein YecF -
  JKN67_RS10840 (JKN67_10785) yecU 2173786..2173962 (-) 177 WP_001302050.1 protein YecU -
  JKN67_RS28385 - 2174000..2174116 (-) 117 WP_001302039.1 hypothetical protein -
  JKN67_RS10845 (JKN67_10790) letA 2174258..2174914 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  JKN67_RS10850 (JKN67_10795) uvrC 2174911..2176743 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  JKN67_RS10855 (JKN67_10800) pgsA 2176800..2177348 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  JKN67_RS10875 (JKN67_10820) - 2178340..2178621 (+) 282 WP_001303543.1 hypothetical protein -
  JKN67_RS10880 (JKN67_10825) - 2178642..2178836 (+) 195 WP_115801851.1 hypothetical protein -
  JKN67_RS10885 (JKN67_10830) - 2178778..2179857 (+) 1080 WP_050543672.1 IS30 family transposase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=500800 JKN67_RS10845 WP_000611328.1 2174258..2174914(+) (letA) [Escherichia coli O157:H7 strain 146N4]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=500800 JKN67_RS10845 WP_000611328.1 2174258..2174914(+) (letA) [Escherichia coli O157:H7 strain 146N4]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTAAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCTGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CATTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACGAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482