Detailed information NTG0498835

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: ISP08_RS04720
• Genome accession: NZ_CP064056
• Coordinates: 992622..993665 (+)
• Length: 347 a.a.
• NCBI ID: WP_061855636.1
• Uniprot ID: A0A7T1B1I5
• Organism: Staphylococcus lloydii strain 23_2_7_LY
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 987622..998665

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ISP08_RS04695 (ISP08_04695)	-	988731..989447 (+)	717	WP_195719463.1	glutamine amidotransferase	-
ISP08_RS04700 (ISP08_04700)	-	989517..990503 (-)	987	WP_195719462.1	aromatic acid exporter family protein	-
ISP08_RS04705 (ISP08_04705)	map	990662..991414 (+)	753	WP_195719461.1	type I methionyl aminopeptidase	-
ISP08_RS04710 (ISP08_04710)	-	991521..991907 (+)	387	WP_048793245.1	hypothetical protein	-
ISP08_RS04715 (ISP08_04715)	liaF	991924..992625 (+)	702	WP_048793244.1	cell wall-active antibiotics response protein LiaF	-
ISP08_RS04720 (ISP08_04720)	vraS	992622..993665 (+)	1044	WP_061855636.1	sensor histidine kinase	Regulator
ISP08_RS04725 (ISP08_04725)	vraR	993655..994284 (+)	630	WP_048793242.1	response regulator transcription factor	Regulator
ISP08_RS04730 (ISP08_04730)	-	994358..995446 (-)	1089	WP_195719460.1	YihY/virulence factor BrkB family protein	-
ISP08_RS04735 (ISP08_04735)	-	995701..995982 (-)	282	WP_048793240.1	hypothetical protein	-
ISP08_RS04740 (ISP08_04740)	-	995989..996453 (-)	465	WP_048793239.1	low molecular weight protein-tyrosine-phosphatase	-
ISP08_RS04745 (ISP08_04745)	-	996586..996789 (+)	204	WP_048793238.1	DUF1128 family protein	-
ISP08_RS04750 (ISP08_04750)	-	996802..998040 (+)	1239	WP_195719459.1	aminopeptidase	-
ISP08_RS04755 (ISP08_04755)	-	998065..998592 (+)	528	WP_195719512.1	acyl-CoA thioesterase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39917.17 Da
• Isoelectric Point: 5.6132

>NTDB_id=498835 ISP08_RS04720 WP_061855636.1 992622..993665(+) (vraS) [Staphylococcus lloydii strain 23_2_7_LY]
MNHYIRAIGSMLILVYSTLIAFFFIDKVFVNIMYFQGMFYTQIFGIPVFLFLNLLIIFLCIIVGSVLAYKINQQNHWLQR
QIERSIEGQTVGVNDQDIELYNETIELYHTLVPLNQEVHKLRMKTQNLTNESYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELAPPLDQQIPTLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVTDLQKKVPMKVVHDI
EDFSVPKGIEDHLFRITQEAISNTLRHSKGTKVTIELFNQADYLLLRVQDNGIGFNVDENTEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLDKEELDAN

Nucleotide

• Length: 1044 bp

>NTDB_id=498835 ISP08_RS04720 WP_061855636.1 992622..993665(+) (vraS) [Staphylococcus lloydii strain 23_2_7_LY]
ATGAATCACTACATAAGAGCTATAGGTTCAATGTTGATATTAGTATACAGTACGTTAATTGCATTTTTTTTTATAGACAA
AGTATTTGTTAATATCATGTACTTCCAAGGTATGTTTTATACACAAATATTTGGGATACCAGTGTTTCTATTTTTAAATT
TATTGATCATATTTTTGTGTATTATAGTGGGTTCGGTGTTAGCTTATAAGATTAATCAACAAAATCATTGGCTACAGCGC
CAAATAGAACGCTCAATAGAAGGGCAAACGGTCGGTGTAAATGATCAAGACATAGAACTGTACAACGAAACTATTGAGTT
ATACCATACACTTGTACCTTTAAATCAAGAAGTACATAAACTTAGAATGAAGACACAAAACTTAACGAATGAATCATATA
ATATAAATGACGTAAAAGTTAAGAAAATTATTGAAGACGAACGTCAAAGACTAGCCAGAGAATTACATGATTCCGTGAGT
CAGCAATTATTTGCTGCTAGTATGATGTTGTCCGCTATAAAAGAAACCGAACTCGCACCGCCATTAGATCAACAAATACC
AACTTTAGAAAAAATGGTGCAAGATTCTCAATTAGAAATGAGAGCTTTACTCTTACATTTAAGACCTATTGGCCTAAAAG
ATAAGTCATTAGGTGAAGGGATTAAAGACTTAGTAACAGATTTACAGAAAAAAGTACCGATGAAAGTCGTACATGATATT
GAAGATTTTTCAGTACCAAAAGGTATAGAAGATCATCTGTTTAGAATAACGCAAGAAGCGATTTCTAATACATTACGTCA
TTCAAAAGGAACTAAAGTTACAATAGAGCTATTTAATCAAGCCGATTACTTATTACTACGTGTACAAGATAATGGTATAG
GTTTTAATGTAGATGAAAATACTGAACAAAGTTATGGTTTAAAAAATATGCGTGAACGTGCATTAGAAATAGGTGCAACA
TTCCATATTGTTTCTCTACCCGATTCAGGTACAAGAATAGAAGTGAAAGCGCCATTAGACAAGGAGGAATTGGATGCCAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A7T1B1I5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	88.338	98.847	0.873