Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   SPYALAB49_RS03515 Genome accession   NC_017596
Coordinates   691914..693143 (+) Length   409 a.a.
NCBI ID   WP_002984948.1    Uniprot ID   A0A4U7GJW1
Organism   Streptococcus pyogenes Alab49     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 686914..698143
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYALAB49_RS03490 (SPYALAB49_000712) - 687530..688807 (-) 1278 WP_002984963.1 hydroxymethylglutaryl-CoA reductase, degradative -
  SPYALAB49_RS03495 (SPYALAB49_000713) - 688794..689969 (-) 1176 WP_002993959.1 hydroxymethylglutaryl-CoA synthase -
  SPYALAB49_RS03500 (SPYALAB49_000714) - 690178..691017 (+) 840 WP_010922172.1 thymidylate synthase -
  SPYALAB49_RS03505 (SPYALAB49_000715) - 691097..691594 (+) 498 WP_014635412.1 dihydrofolate reductase -
  SPYALAB49_RS09770 (SPYALAB49_000716) - 691614..691784 (+) 171 WP_002984950.1 hypothetical protein -
  SPYALAB49_RS03515 (SPYALAB49_000717) clpX 691914..693143 (+) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  SPYALAB49_RS03520 (SPYALAB49_000718) yihA 693153..693752 (+) 600 WP_002984945.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  SPYALAB49_RS03525 (SPYALAB49_000719) - 693900..694643 (+) 744 WP_002984942.1 hypothetical protein -
  SPYALAB49_RS03530 (SPYALAB49_000720) - 694701..696800 (-) 2100 WP_014635413.1 AAA family ATPase -
  SPYALAB49_RS03535 (SPYALAB49_000721) rpiA 697178..697861 (+) 684 WP_014635414.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 44991.44 Da        Isoelectric Point: 4.5775

>NTDB_id=49533 SPYALAB49_RS03515 WP_002984948.1 691914..693143(+) (clpX) [Streptococcus pyogenes Alab49]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=49533 SPYALAB49_RS03515 WP_002984948.1 691914..693143(+) (clpX) [Streptococcus pyogenes Alab49]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATCGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U7GJW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.998

100

0.89
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575

Multiple sequence alignment