Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   KIM12_RS12305 Genome accession   NZ_CP074900
Coordinates   2404393..2405049 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain 10_253     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2399393..2410049
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KIM12_RS12270 (KIM12_12145) dcyD 2400272..2401258 (+) 987 WP_001128238.1 D-cysteine desulfhydrase -
  KIM12_RS12275 (KIM12_12150) tcyL 2401273..2401941 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  KIM12_RS12280 (KIM12_12155) tcyN 2401938..2402690 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  KIM12_RS12285 (KIM12_12160) sdiA 2402920..2403642 (+) 723 WP_001154265.1 transcriptional regulator SdiA -
  KIM12_RS12290 (KIM12_12165) yecF 2403710..2403934 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  KIM12_RS12295 (KIM12_12170) yecU 2403921..2404097 (-) 177 WP_001342215.1 protein YecU -
  KIM12_RS12300 - 2404135..2404251 (-) 117 WP_001302039.1 hypothetical protein -
  KIM12_RS12305 (KIM12_12175) letA 2404393..2405049 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  KIM12_RS12310 (KIM12_12180) uvrC 2405046..2406878 (+) 1833 WP_001283424.1 excinuclease ABC subunit UvrC Machinery gene
  KIM12_RS12315 (KIM12_12185) pgsA 2406935..2407483 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  KIM12_RS12335 (KIM12_12205) - 2408476..2408757 (+) 282 WP_001303543.1 hypothetical protein -
  KIM12_RS12340 (KIM12_12210) - 2408946..2409086 (-) 141 WP_000078921.1 Hok/Gef family protein -
  KIM12_RS12345 (KIM12_12215) - 2409277..2409537 (-) 261 WP_000488107.1 ogr/Delta-like zinc finger family protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=494971 KIM12_RS12305 WP_000611328.1 2404393..2405049(+) (letA) [Escherichia coli strain 10_253]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=494971 KIM12_RS12305 WP_000611328.1 2404393..2405049(+) (letA) [Escherichia coli strain 10_253]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482