Detailed information NTG0049362

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPNINV200_RS11065
• Genome accession: NC_017593
• Coordinates: 2088129..2088881 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae INV200
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2083129..2093881

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNINV200_RS13575	-	2085562..2087165 (-)	1604	Protein_2047	YhgE/Pip family protein	-
SPNINV200_RS11050 (SPNINV200_20430)	-	2087344..2087886 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SPNINV200_RS11065 (SPNINV200_20440)	comE	2088129..2088881 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPNINV200_RS11070 (SPNINV200_20450)	comD/comD1	2088878..2090203 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
SPNINV200_RS11075 (SPNINV200_20460)	comC/comC1	2090224..2090349 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPNINV200_RS11085 (SPNINV200_20480)	rlmH	2090631..2091110 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPNINV200_RS11090 (SPNINV200_20490)	htrA	2091293..2092474 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
SPNINV200_RS11095 (SPNINV200_20500)	spo0J	2092532..2093290 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=49362 SPNINV200_RS11065 WP_000866065.1 2088129..2088881(-) (comE) [Streptococcus pneumoniae INV200]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=49362 SPNINV200_RS11065 WP_000866065.1 2088129..2088881(-) (comE) [Streptococcus pneumoniae INV200]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408