Detailed information NTG0049360

Bioinformatically predicted

Overview

• Name: comFC/cflB
• Type: Machinery gene
• Locus tag: SPNINV200_RS10910
• Genome accession: NC_017593
• Coordinates: 2060242..2060904 (-)
• Length: 220 a.a.
• NCBI ID: WP_000649968.1
• Uniprot ID: A0A098Z9B1
• Organism: Streptococcus pneumoniae INV200
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2055242..2065904

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPNINV200_RS10885 (SPNINV200_20110)	-	2055392..2055658 (-)	267	WP_001278167.1	Veg family protein	-
SPNINV200_RS10890 (SPNINV200_20120)	dnaB	2055660..2057012 (-)	1353	WP_000852486.1	replicative DNA helicase	-
SPNINV200_RS10895 (SPNINV200_20130)	rplI	2057056..2057508 (-)	453	WP_000864220.1	50S ribosomal protein L9	-
SPNINV200_RS10900 (SPNINV200_20140)	-	2057505..2059478 (-)	1974	WP_000715116.1	DHH family phosphoesterase	-
SPNINV200_RS10905 (SPNINV200_20150)	hpf	2059614..2060162 (-)	549	WP_000599107.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
SPNINV200_RS10910 (SPNINV200_20160)	comFC/cflB	2060242..2060904 (-)	663	WP_000649968.1	ComF family protein	Machinery gene
SPNINV200_RS10915 (SPNINV200_20170)	comFA/cflA	2060901..2062199 (-)	1299	WP_000867592.1	DEAD/DEAH box helicase	Machinery gene
SPNINV200_RS10920 (SPNINV200_20180)	-	2062255..2062890 (+)	636	WP_000395739.1	YigZ family protein	-
SPNINV200_RS10925 (SPNINV200_20190)	cysK	2063175..2064095 (+)	921	WP_000029860.1	cysteine synthase A	-
SPNINV200_RS10930 (SPNINV200_20200)	-	2064170..2064708 (-)	539	Protein_2026	IS66 family transposase	-
SPNINV200_RS10935	-	2064681..2064989 (+)	309	Protein_2027	transposase	-
SPNINV200_RS10940 (SPNINV200_20220)	tnpB	2065012..2065362 (-)	351	WP_000973411.1	IS66 family insertion sequence element accessory protein TnpB	-

Sequence

Protein

• Length: 220 a.a.
• Molecular weight: 25203.05 Da
• Isoelectric Point: 7.7116

>NTDB_id=49360 SPNINV200_RS10910 WP_000649968.1 2060242..2060904(-) (comFC/cflB) [Streptococcus pneumoniae INV200]
MKCLLCGQTMKTVLTFSSLLLLRNDDSCLCSDCDSTFERIGEENCPNCMKTELSTKCQDCQFWCKEGVGVSHRAIFTYNQ
AMKDFFSRYKFDGDFLLRKVFASFLSEELKKYKEYQFVVIPLSPDRYANRGFNQVEGLVEAAGFEYLDLLEKREERASSS
KNRSERLGTELPFFIKSGVTIPKKILLIDDIYTTGATINRVKKLLEEAGAKDVKTFSLVR

Nucleotide

• Length: 663 bp

>NTDB_id=49360 SPNINV200_RS10910 WP_000649968.1 2060242..2060904(-) (comFC/cflB) [Streptococcus pneumoniae INV200]
ATGAAGTGCTTGTTATGTGGGCAGACTATGAAGACTGTTTTAACTTTTAGTAGTCTCTTACTTCTGAGGAATGATGACTC
TTGTCTTTGTTCAGACTGTGATTCTACTTTTGAAAGAATTGGGGAAGAGAACTGTCCAAATTGTATGAAAACAGAGTTGT
CAACAAAGTGTCAAGATTGTCAATTTTGGTGTAAAGAAGGAGTTGGAGTCAGTCATAGAGCGATTTTTACTTACAATCAA
GCTATGAAGGATTTTTTCAGTCGGTATAAGTTTGATGGAGACTTCCTGTTAAGAAAAGTTTTCGCTTCATTTTTAAGTGA
GGAGTTGAAAAAGTACAAAGAGTATCAATTTGTTGTAATTCCCCTAAGTCCTGATAGATATGCTAATAGAGGATTTAATC
AGGTTGAGGGCTTGGTAGAGGCAGCAGGCTTTGAGTATCTGGATTTATTAGAGAAAAGAGAAGAGAGAGCCAGTTCTTCT
AAAAATCGTTCAGAGCGCTTGGGGACAGAACTTCCTTTCTTTATTAAAAGTGGAGTCACTATTCCTAAAAAAATCCTACT
TATAGATGATATCTATACTACAGGAGCAACTATAAATCGTGTTAAGAAACTGTTGGAAGAAGCTGGTGCTAAGGATGTAA
AAACATTTTCCCTTGTAAGATGA

Domains

Predicted by InterproScan.

• Phosphoribosyl transferase domain (Pribosyltran) (153-219)

3D structure

• AlphaFold DB: A0A098Z9B1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comFC/cflB	Streptococcus pneumoniae Rx1	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae D39	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae R6	99.545	100	0.995
comFC/cflB	Streptococcus pneumoniae TIGR4	99.091	100	0.991
comFC/cflB	Streptococcus mitis SK321	91.364	100	0.914
comFC/cflB	Streptococcus mitis NCTC 12261	90.909	100	0.909