Detailed information NTG0489807

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF723_RS00505
• Genome accession: NZ_CP062414
• Coordinates: 91028..92071 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_175
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86028..97071

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF723_RS00475 (IF723_00460)	-	86457..86567 (+)	111	WP_001790257.1	hypothetical protein	-
IF723_RS00480 (IF723_00465)	-	86596..87009 (+)	414	WP_025173836.1	hypothetical protein	-
IF723_RS00485 (IF723_00470)	-	87440..88426 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
IF723_RS00490 (IF723_00475)	map	88954..89712 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF723_RS00495 (IF723_00480)	-	89929..90315 (+)	387	WP_001110179.1	hypothetical protein	-
IF723_RS00500 (IF723_00485)	liaF	90330..91031 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IF723_RS00505 (IF723_00490)	vraS	91028..92071 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF723_RS00510 (IF723_00495)	vraR	92061..92690 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF723_RS00515 (IF723_00500)	-	92802..94019 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
IF723_RS00520 (IF723_00505)	-	94297..94572 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF723_RS00525 (IF723_00510)	-	94579..95043 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF723_RS00530 (IF723_00515)	-	95190..95390 (+)	201	WP_000180460.1	DUF1128 family protein	-
IF723_RS00535 (IF723_00520)	-	95393..96649 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=489807 IF723_RS00505 WP_001017131.1 91028..92071(+) (vraS) [Staphylococcus aureus strain NAS_AN_175]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=489807 IF723_RS00505 WP_001017131.1 91028..92071(+) (vraS) [Staphylococcus aureus strain NAS_AN_175]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1