Detailed information NTG0488463

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF722_RS09335
• Genome accession: NZ_CP062360
• Coordinates: 1907503..1908546 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_157
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1902503..1913546

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF722_RS09305 (IF722_09260)	-	1902924..1904180 (-)	1257	WP_001793428.1	aminopeptidase	-
IF722_RS09310 (IF722_09265)	-	1904183..1904383 (-)	201	WP_000180460.1	DUF1128 family protein	-
IF722_RS09315 (IF722_09270)	-	1904530..1904994 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF722_RS09320 (IF722_09275)	-	1905001..1905276 (+)	276	WP_072491832.1	YtxH domain-containing protein	-
IF722_RS09325 (IF722_09280)	-	1905554..1906771 (+)	1218	WP_072491831.1	YihY/virulence factor BrkB family protein	-
IF722_RS09330 (IF722_09285)	vraR	1906884..1907513 (-)	630	WP_072491830.1	two-component system response regulator VraR	Regulator
IF722_RS09335 (IF722_09290)	vraS	1907503..1908546 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF722_RS09340 (IF722_09295)	liaF	1908543..1909244 (-)	702	WP_098818122.1	cell wall-active antibiotics response protein LiaF	-
IF722_RS09345 (IF722_09300)	-	1909259..1909645 (-)	387	WP_001110179.1	hypothetical protein	-
IF722_RS09350 (IF722_09305)	map	1909862..1910620 (-)	759	WP_061732059.1	type I methionyl aminopeptidase	-
IF722_RS09355 (IF722_09310)	-	1911087..1912073 (+)	987	WP_240025146.1	aromatic acid exporter family protein	-
IF722_RS09360 (IF722_09315)	-	1912262..1912675 (-)	414	WP_072491843.1	hypothetical protein	-
IF722_RS09365 (IF722_09320)	-	1912704..1912815 (-)	112	Protein_1805	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488463 IF722_RS09335 WP_001017131.1 1907503..1908546(-) (vraS) [Staphylococcus aureus strain NAS_AN_157]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488463 IF722_RS09335 WP_001017131.1 1907503..1908546(-) (vraS) [Staphylococcus aureus strain NAS_AN_157]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTGGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1