Detailed information NTG0488136

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IF739_RS00450
• Genome accession: NZ_CP062346
• Coordinates: 82272..83315 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain NAS_AN_261
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 77272..88315

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IF739_RS00420 (IF739_00420)	-	78004..78114 (+)	111	WP_001790257.1	hypothetical protein	-
IF739_RS00425 (IF739_00425)	-	78143..78556 (+)	414	WP_025174475.1	hypothetical protein	-
IF739_RS00430 (IF739_00430)	-	78745..79731 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
IF739_RS00435 (IF739_00435)	map	80198..80956 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IF739_RS00440 (IF739_00440)	-	81173..81559 (+)	387	WP_001110179.1	hypothetical protein	-
IF739_RS00445 (IF739_00445)	liaF	81574..82275 (+)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
IF739_RS00450 (IF739_00450)	vraS	82272..83315 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IF739_RS00455 (IF739_00455)	vraR	83305..83934 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IF739_RS00460 (IF739_00460)	-	84047..85264 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
IF739_RS00465 (IF739_00465)	-	85542..85817 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
IF739_RS00470 (IF739_00470)	-	85824..86288 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IF739_RS00475 (IF739_00475)	-	86435..86635 (+)	201	WP_000180462.1	DUF1128 family protein	-
IF739_RS00480 (IF739_00480)	-	86638..87894 (+)	1257	WP_078103411.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=488136 IF739_RS00450 WP_001017131.1 82272..83315(+) (vraS) [Staphylococcus aureus strain NAS_AN_261]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=488136 IF739_RS00450 WP_001017131.1 82272..83315(+) (vraS) [Staphylococcus aureus strain NAS_AN_261]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1