Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   KEW59_RS20635 Genome accession   NZ_CP073621
Coordinates   4379663..4380319 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain CE2050     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4374663..4385319
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KEW59_RS20605 (KEW59_20445) dcyD 4375543..4376529 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  KEW59_RS20610 (KEW59_20450) tcyL 4376544..4377212 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  KEW59_RS20615 (KEW59_20455) tcyN 4377209..4377961 (+) 753 WP_001273003.1 L-cystine ABC transporter ATP-binding protein TcyN -
  KEW59_RS20620 (KEW59_20460) sdiA 4378191..4378913 (+) 723 WP_001154271.1 transcriptional regulator SdiA -
  KEW59_RS20625 (KEW59_20465) yecF 4378980..4379204 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  KEW59_RS20630 (KEW59_20470) yecU 4379191..4379367 (-) 177 WP_000590347.1 protein YecU -
  KEW59_RS20635 (KEW59_20475) letA 4379663..4380319 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  KEW59_RS20640 (KEW59_20480) uvrC 4380316..4382148 (+) 1833 WP_001595863.1 excinuclease ABC subunit UvrC Machinery gene
  KEW59_RS20645 (KEW59_20485) pgsA 4382205..4382753 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  KEW59_RS20665 (KEW59_20505) - 4383460..4384191 (-) 732 WP_001595862.1 hypothetical protein -
  KEW59_RS20670 (KEW59_20510) - 4384272..4384955 (+) 684 Protein_4029 Arm DNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=487469 KEW59_RS20635 WP_000611328.1 4379663..4380319(+) (letA) [Escherichia coli strain CE2050]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=487469 KEW59_RS20635 WP_000611328.1 4379663..4380319(+) (letA) [Escherichia coli strain CE2050]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCTGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482