Detailed information NTG0048584

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: I872_RS09965
• Genome accession: NC_021175
• Coordinates: 2017995..2020544 (-)
• Length: 849 a.a.
• NCBI ID: WP_015605963.1
• Uniprot ID: A0ABM5NMG8
• Organism: Streptococcus cristatus AS 1.3089
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 2012995..2025544

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I872_RS09940 (I872_09965)	-	2013563..2014069 (+)	507	WP_015605958.1	helix-turn-helix domain-containing protein	-
I872_RS09945 (I872_09970)	-	2014053..2014628 (+)	576	WP_015605959.1	RDD family protein	-
I872_RS09950 (I872_09975)	hexB	2014761..2016707 (-)	1947	WP_015605960.1	DNA mismatch repair endonuclease MutL	Machinery gene
I872_RS09955 (I872_09980)	brsR	2016892..2017332 (+)	441	WP_015605961.1	LytTR family DNA-binding domain-containing protein	Regulator
I872_RS09960 (I872_09985)	-	2017329..2017799 (+)	471	WP_015605962.1	DUF3021 family protein	-
I872_RS09965 (I872_09990)	hexA	2017995..2020544 (-)	2550	WP_015605963.1	DNA mismatch repair protein MutS	Machinery gene
I872_RS09970 (I872_09995)	argR	2020617..2021057 (-)	441	WP_015605964.1	arginine repressor	-
I872_RS09975 (I872_10000)	argS	2021183..2022871 (+)	1689	WP_015605965.1	arginine--tRNA ligase	-
I872_RS09980 (I872_10005)	-	2022923..2023186 (+)	264	WP_015605966.1	hypothetical protein	-
I872_RS09985 (I872_10010)	nrdI	2023238..2023699 (-)	462	WP_015605967.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
I872_RS09990 (I872_10015)	-	2023773..2024294 (-)	522	WP_231913940.1	lantibiotic ABC transporter permease	-

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 94825.26 Da
• Isoelectric Point: 4.9265

>NTDB_id=48584 I872_RS09965 WP_015605963.1 2017995..2020544(-) (hexA) [Streptococcus cristatus AS 1.3089]
MAAEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVNAAQILEISLTSRNKNAENPVPMAGVPYHSAQQYIDVLV
ESGYKVAIAEQMEDPKEAKGVVKREVVQVITPGTVVDSNKPDSANNFLVALDYSDGLYGLAYMDLVTGEFQVTSLEDFAL
VCGEIRNLKAREVVLGYALPEGEEQVLAGQMNLLLSYVQTALDDVQLLDEELSPMERQAAGKLLEYVHRTQMRELSHLKK
VQHYEIKDFLQMDYATKASLDLTENARSGKKHGSLYWLMDETKTAMGGRMLRSWIQRPLIDEARIIQRQNVVEVFLDHFF
ERSDLTESLKGVYDIERLASRVSFGKTNPKDLLQLAATLGNVPQIKAILQGIGSPHLVPLIEGLDPIPELAGLISSAISP
DAPHVITEGNIIRTGFDETLDQYRLVLREGTGWIAELEVKERANSGISNLKIDYNKKDGYYFHVTNSQLAHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEVGKYIQRLQALAQTLAAVDVLQSFAAVAEQQHLVRPVFT
AERRLQIEKGRHPVVEKVMGAQSYIPNSILLDQETDIQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVPAQSASLPLFDA
IFTRIGAADDLVSGQSTFMVEMMEANRAIRQASERSLILFDELGRGTATYDGMALAQAIIEHIHHYTGAKTLFATHYHEL
TALENSLEHLENVHVATLEKDGQVTFLHKIEPGPADKSYGIHVAKIAGLPEKLLERADNILSHLESQDTGLGSELPAASR
PKQSQVAEQMSLFAEGPENPVLTELRDLDIYNMTPLEVMAAVAELKKKL

Nucleotide

• Length: 2550 bp

>NTDB_id=48584 I872_RS09965 WP_015605963.1 2017995..2020544(-) (hexA) [Streptococcus cristatus AS 1.3089]
ATGGCAGCAGAAAAATTATCACCCGGTATGCAGCAGTATTTGGATATCAAAAAGGACTATCCAGATGCTTTTCTGCTCTT
TAGGATGGGAGATTTCTATGAGTTGTTTTATGATGATGCGGTCAATGCCGCCCAGATTTTAGAGATTTCTCTCACCAGCC
GAAATAAAAATGCAGAAAATCCTGTTCCCATGGCTGGAGTTCCCTATCATTCGGCACAGCAGTATATTGATGTTTTGGTC
GAATCAGGCTATAAGGTAGCGATTGCGGAGCAGATGGAAGATCCCAAGGAAGCCAAGGGAGTTGTTAAGCGGGAGGTCGT
TCAGGTTATCACGCCGGGGACGGTGGTGGACTCCAATAAGCCCGACTCTGCTAATAACTTTCTGGTGGCTCTGGATTACT
CAGATGGTCTCTATGGTCTAGCTTATATGGACTTGGTGACTGGTGAGTTTCAGGTGACTAGTTTAGAGGACTTTGCCTTG
GTCTGCGGGGAAATCCGCAATTTGAAAGCTAGGGAAGTGGTGCTGGGCTATGCCTTGCCAGAAGGTGAGGAGCAGGTCTT
GGCTGGACAGATGAACCTTTTACTGTCCTATGTACAGACAGCCTTGGACGATGTCCAGTTGCTGGACGAGGAGCTGTCTC
CGATGGAACGTCAGGCAGCGGGGAAACTGCTGGAGTACGTGCACCGGACCCAGATGAGGGAGCTCAGCCATTTGAAGAAG
GTTCAGCATTATGAAATCAAGGACTTTCTGCAAATGGATTATGCTACTAAGGCGAGTCTGGATTTGACGGAAAATGCTCG
CTCAGGCAAGAAGCACGGCAGTCTTTATTGGCTGATGGACGAGACCAAGACGGCCATGGGCGGACGTATGCTGCGCTCTT
GGATTCAGCGTCCGCTGATTGATGAAGCGCGAATTATCCAGCGGCAGAATGTCGTCGAGGTTTTTCTGGATCATTTCTTT
GAGCGGAGTGATTTGACGGAGAGCCTCAAGGGAGTCTATGATATCGAGCGGCTGGCTAGTCGAGTTTCTTTTGGTAAGAC
CAATCCCAAGGATCTGCTGCAGCTGGCAGCTACCCTGGGCAATGTGCCTCAGATTAAGGCTATTCTGCAAGGGATTGGCA
GCCCGCATCTAGTGCCTTTGATTGAGGGCTTGGATCCTATTCCAGAGTTGGCGGGCTTGATTAGCTCAGCTATTTCACCG
GATGCGCCCCATGTCATCACCGAGGGCAATATCATTCGGACCGGTTTTGATGAGACTTTGGATCAGTATCGACTTGTGCT
GAGGGAGGGGACCGGCTGGATTGCAGAGCTGGAAGTCAAAGAACGTGCCAACAGCGGCATCAGCAATCTAAAGATTGATT
ACAACAAAAAAGATGGTTACTATTTCCACGTGACCAATTCCCAGCTGGCTCATGTGCCCAGTCATTTCTTCCGCAAGGCG
ACCCTGAAAAATTCGGAGCGTTTCGGAACGGAGGAGCTGGCCCGAATTGAGGGAGAGATGTTGGAGGCGCGTGAAAAATC
TGCCAACTTGGAATACGAGATTTTCATGCGGATTCGCGAGGAAGTTGGCAAATATATCCAGCGCTTGCAGGCCTTGGCAC
AAACGCTGGCAGCTGTGGATGTCCTGCAGAGCTTTGCTGCGGTGGCAGAACAGCAGCATTTGGTGCGCCCTGTCTTTACT
GCGGAGCGCCGTCTGCAGATTGAAAAAGGCCGCCATCCTGTCGTAGAAAAGGTCATGGGTGCCCAAAGCTACATTCCAAA
TAGTATTCTGCTGGATCAGGAAACAGACATCCAGCTGATTACTGGGCCTAATATGAGCGGGAAATCGACTTATATGCGCC
AGCTGGCAATCATCGTCATCATGGCACAGATGGGATCTTATGTGCCCGCTCAGTCTGCCAGTCTGCCACTATTCGACGCG
ATTTTCACTCGCATCGGTGCAGCGGATGATTTGGTGTCCGGCCAGTCCACCTTTATGGTGGAGATGATGGAGGCCAATCG
GGCCATTCGACAGGCCAGCGAGCGTTCGCTCATTCTCTTTGATGAGCTGGGCCGTGGGACGGCTACTTACGATGGGATGG
CCTTGGCTCAGGCTATTATCGAGCATATTCATCACTATACTGGGGCCAAAACCCTCTTTGCTACCCACTATCACGAGCTG
ACAGCCTTAGAGAATAGCTTGGAGCATTTGGAAAATGTCCATGTGGCAACCTTGGAAAAGGACGGGCAGGTGACTTTCCT
GCATAAGATTGAGCCGGGTCCGGCTGACAAGTCCTACGGAATTCATGTGGCGAAGATTGCCGGACTTCCTGAGAAATTAC
TAGAGCGGGCGGATAACATTTTGAGTCATTTGGAGAGTCAGGACACTGGACTAGGCTCAGAGCTTCCTGCTGCATCCAGA
CCGAAGCAGTCACAAGTGGCTGAGCAGATGTCTCTTTTCGCAGAAGGACCGGAAAATCCAGTCCTAACTGAACTCCGAGA
CTTGGACATCTATAATATGACTCCCCTGGAAGTCATGGCGGCGGTAGCCGAGCTCAAGAAAAAGCTGTAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain III (MutS_III) (256-546)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	77.739	100	0.777
mutS	Pseudomonas stutzeri strain ATCC 17587	38.973	100	0.393