Detailed information NTG0048170

Bioinformatically predicted

Overview

• Name: pilD
• Type: Machinery gene
• Locus tag: NMBNZ0533_RS10800
• Genome accession: NC_017518
• Coordinates: 2080597..2081457 (+)
• Length: 286 a.a.
• NCBI ID: WP_002241067.1
• Uniprot ID: A1KVV2
• Organism: Neisseria meningitidis NZ-05/33
• Function: assembly of type IV pilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2075597..2086457

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NMBNZ0533_RS10785 (NMBNZ0533_1910)	dapD	2076107..2076928 (-)	822	WP_002255671.1	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-
NMBNZ0533_RS13540	-	2076938..2077168 (-)	231	WP_002212338.1	hypothetical protein	-
NMBNZ0533_RS10790 (NMBNZ0533_1911)	pgi	2077138..2078781 (-)	1644	WP_014581240.1	glucose-6-phosphate isomerase	-
NMBNZ0533_RS10795 (NMBNZ0533_1912)	pilG	2079291..2080523 (+)	1233	WP_002216405.1	type 4 pilus assembly protein PilG	Machinery gene
NMBNZ0533_RS10800 (NMBNZ0533_1913)	pilD	2080597..2081457 (+)	861	WP_002241067.1	A24 family peptidase	Machinery gene
NMBNZ0533_RS10805 (NMBNZ0533_1914)	coaE	2081459..2082091 (+)	633	WP_002216402.1	dephospho-CoA kinase	-
NMBNZ0533_RS10810 (NMBNZ0533_1915)	-	2082084..2082293 (+)	210	WP_002216401.1	DNA gyrase inhibitor YacG	-
NMBNZ0533_RS10815 (NMBNZ0533_1916)	pilF	2082378..2084054 (-)	1677	WP_002221967.1	type IV-A pilus assembly ATPase PilB	Machinery gene
NMBNZ0533_RS10825 (NMBNZ0533_1918)	-	2084545..2084991 (-)	447	WP_002220271.1	DUF441 domain-containing protein	-
NMBNZ0533_RS10830 (NMBNZ0533_1919)	ispB	2084996..2085970 (-)	975	WP_002221965.1	octaprenyl diphosphate synthase	-

Sequence

Protein

• Length: 286 a.a.
• Molecular weight: 31331.48 Da
• Isoelectric Point: 9.1920

>NTDB_id=48170 NMBNZ0533_RS10800 WP_002241067.1 2080597..2081457(+) (pilD) [Neisseria meningitidis NZ-05/33]
MSDLSVLSPFAVPLAAVFGLLVGSFLNVVIYRVPVMMERGWTVFAKKHLNLPLTEKESRTFNLMKPDSCCPKCRVPIRAW
QNIPIVSYLLLRGKCASCQTKISIRYPLIELLTGVLFGLVAWQYGWSWITLGGLILTAFLISLTFIDADTQYLPDSMTLP
LIWLGLIFNLDGGFVPLQSAVLGAVAGYGSIWLLCAVYKLIKGEIGMGNGDFKLIAALGAWLGISALPVLIFVSSLIGLV
AAIVMRVAKGQHFAFGPALTVSGWIIFTANDSVWRAVNWWLTHPVL

Nucleotide

• Length: 861 bp

>NTDB_id=48170 NMBNZ0533_RS10800 WP_002241067.1 2080597..2081457(+) (pilD) [Neisseria meningitidis NZ-05/33]
ATGTCTGATTTGTCTGTATTGTCGCCGTTTGCCGTGCCTTTGGCAGCGGTGTTCGGGCTGCTGGTCGGCAGTTTCTTAAA
CGTCGTCATTTACCGCGTGCCGGTCATGATGGAACGCGGCTGGACGGTATTTGCCAAAAAACATTTAAACCTGCCGCTGA
CCGAAAAGGAAAGCCGTACCTTCAACCTGATGAAACCGGATTCCTGCTGTCCCAAATGCCGCGTGCCGATACGCGCGTGG
CAGAACATCCCGATTGTCAGCTACCTGCTCCTGCGCGGCAAATGCGCTTCCTGCCAAACCAAAATCAGCATACGTTATCC
CTTAATCGAGCTGCTGACCGGCGTATTATTCGGGCTGGTCGCCTGGCAATACGGCTGGTCTTGGATTACATTGGGCGGTT
TGATACTGACCGCGTTTCTGATTTCCCTGACCTTTATCGATGCGGACACCCAATACCTGCCCGACTCGATGACACTGCCC
TTGATTTGGCTGGGGCTGATATTTAATTTGGACGGCGGCTTCGTGCCTTTGCAGTCTGCCGTTTTAGGTGCGGTTGCCGG
CTATGGTTCGATATGGCTTTTATGCGCGGTATATAAACTGATTAAAGGCGAAATCGGTATGGGCAACGGAGATTTCAAAC
TGATTGCCGCATTGGGCGCGTGGCTCGGCATATCCGCATTGCCCGTGCTGATTTTTGTTTCCTCGCTGATCGGTTTGGTC
GCGGCAATCGTTATGCGCGTCGCCAAGGGGCAGCATTTTGCCTTCGGCCCCGCACTGACAGTTTCGGGCTGGATAATTTT
TACGGCAAACGATTCCGTATGGCGGGCGGTCAACTGGTGGCTGACCCATCCGGTGCTGTAA

Domains

Predicted by InterproScan.

• Type IV leader peptidase family (Peptidase_A24) (134-242)

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (17-124)

3D structure

• AlphaFold DB: A1KVV2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilD	Neisseria gonorrhoeae MS11	96.14	99.65	0.958
pilD	Vibrio cholerae strain A1552	44.444	100	0.448
pilD	Acinetobacter baumannii D1279779	46.97	92.308	0.434
pilD	Acinetobacter nosocomialis M2	46.97	92.308	0.434
pilD	Vibrio campbellii strain DS40M4	44.565	96.503	0.43