Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   D39N_RS02355 Genome accession   NZ_CP061208
Coordinates   477706..478443 (+) Length   245 a.a.
NCBI ID   WP_001219139.1    Uniprot ID   Q9F2F6
Organism   Streptococcus pneumoniae strain D39_P0     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 472706..483443
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  D39N_RS02325 (D39N_00464) - 474038..474325 (-) 288 WP_000777760.1 hypothetical protein -
  D39N_RS02330 (D39N_00465) - 474335..474745 (-) 411 WP_001278301.1 HIT family protein -
  D39N_RS02335 (D39N_00466) pptA 474813..475544 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  D39N_RS02340 (D39N_00467) - 475541..476590 (+) 1050 WP_000653770.1 ABC transporter permease -
  D39N_RS02345 (D39N_00468) - 476758..477087 (-) 330 WP_000132569.1 hypothetical protein -
  D39N_RS02350 (D39N_00469) - 477363..477701 (+) 339 WP_000682124.1 LytTR family DNA-binding domain-containing protein -
  D39N_RS02355 (D39N_00470) comE/blpR 477706..478443 (+) 738 WP_001219139.1 response regulator transcription factor Regulator
  D39N_RS02360 (D39N_00471) - 478457..479797 (+) 1341 WP_001017622.1 sensor histidine kinase -
  D39N_RS02365 (D39N_00472) blpC 479839..479994 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  D39N_RS02370 (D39N_00473) - 480051..481412 (-) 1362 Protein_473 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28814.94 Da        Isoelectric Point: 6.0454

>NTDB_id=481385 D39N_RS02355 WP_001219139.1 477706..478443(+) (comE/blpR) [Streptococcus pneumoniae strain D39_P0]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=481385 D39N_RS02355 WP_001219139.1 477706..478443(+) (comE/blpR) [Streptococcus pneumoniae strain D39_P0]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9F2F6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384