Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SPN994038_RS02015 Genome accession   NC_021026
Coordinates   371628..372260 (+) Length   210 a.a.
NCBI ID   WP_000698438.1    Uniprot ID   -
Organism   Streptococcus pneumoniae SPN994038     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 366628..377260
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN994038_RS01990 (SPN994038_03730) mvaD 366905..367858 (+) 954 WP_000373456.1 diphosphomevalonate decarboxylase -
  SPN994038_RS01995 (SPN994038_03740) - 367845..368852 (+) 1008 WP_000562427.1 phosphomevalonate kinase -
  SPN994038_RS02000 (SPN994038_03750) fni 368836..369846 (+) 1011 WP_000210616.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  SPN994038_RS02005 (SPN994038_03760) liaF 369924..370622 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  SPN994038_RS02010 (SPN994038_03770) - 370619..371614 (+) 996 WP_000743662.1 sensor histidine kinase -
  SPN994038_RS02015 (SPN994038_03780) vraR 371628..372260 (+) 633 WP_000698438.1 response regulator transcription factor Regulator
  SPN994038_RS12875 (SPN994038_03790) - 372336..373030 (+) 695 Protein_395 DNA alkylation repair protein -
  SPN994038_RS02035 - 373180..373419 (+) 240 WP_000754501.1 hypothetical protein -
  SPN994038_RS02040 (SPN994038_03800) cbpG 373500..374090 (+) 591 Protein_397 choline-binding protein CbpG -
  SPN994038_RS02045 (SPN994038_03810) - 374392..374784 (+) 393 WP_000378125.1 tyrosine-type recombinase/integrase -
  SPN994038_RS02050 (SPN994038_03820) tig 374945..376228 (+) 1284 WP_000116468.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23583.06 Da        Isoelectric Point: 4.5791

>NTDB_id=48023 SPN994038_RS02015 WP_000698438.1 371628..372260(+) (vraR) [Streptococcus pneumoniae SPN994038]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQATVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=48023 SPN994038_RS02015 WP_000698438.1 371628..372260(+) (vraR) [Streptococcus pneumoniae SPN994038]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGACTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-114)

Bacterial regulatory proteins, luxR family (GerE)

(145-199)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment