Detailed information NTG0047843

Bioinformatically predicted

Overview

• Name: pilA
• Type: Machinery gene
• Locus tag: NMAA_RS00215
• Genome accession: NC_017512
• Coordinates: 36986..38251 (+)
• Length: 421 a.a.
• NCBI ID: WP_002220091.1
• Uniprot ID: X5EMG2
• Organism: Neisseria meningitidis WUE 2594
• Function: assembly of type IV pilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 31986..43251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NMAA_RS00195 (NMAA_0029)	-	32717..33718 (+)	1002	WP_002216162.1	thiamine ABC transporter substrate-binding protein	-
NMAA_RS00200 (NMAA_0030)	-	33812..34660 (+)	849	WP_002246544.1	mechanosensitive ion channel family protein	-
NMAA_RS00205 (NMAA_0031)	-	34686..35171 (+)	486	WP_002221794.1	CinA family protein	-
NMAA_RS00210 (NMAA_0032)	msrAB	35273..36841 (-)	1569	WP_002233356.1	bifunctional peptide-methionine (S)-S-oxide reductase MsrA/peptide-methionine (R)-S-oxide reductase MsrB	-
NMAA_RS00215 (NMAA_0033)	pilA	36986..38251 (+)	1266	WP_002220091.1	signal recognition particle-docking protein FtsY	Machinery gene
NMAA_RS00220 (NMAA_0034)	-	38840..39124 (+)	285	WP_002246543.1	GIY-YIG nuclease family protein	-
NMAA_RS14700	-	39561..39755 (-)	195	WP_025461142.1	hypothetical protein	-
NMAA_RS00230 (NMAA_0035)	pilC	39684..42816 (+)	3133	Protein_40	PilC family type IV pilus tip adhesin	-

Sequence

Protein

• Length: 421 a.a.
• Molecular weight: 45189.45 Da
• Isoelectric Point: 4.5275

>NTDB_id=47843 NMAA_RS00215 WP_002220091.1 36986..38251(+) (pilA) [Neisseria meningitidis WUE 2594]
MFSFFRRKKKQETPALEEAQIQETAAKAESETDQVIENIKEDAESLAESVKGQVESAVETVSGAVEQVKETVAEMLSEAE
EAAEKAAEQVEAAKEAIAETVGEAVGQVQEAVATTEEHKLGWAARLKQGLTKSRDKMAKSLAGVFGGGQIDEDLYEELET
VLITSDMGMEATEYLMKDVRDRVSLKGLKDGNELRGALKEALYDLIKPLEKPLVLPETKEPFVIMLAGINGAGKTTSIGK
LAKYFQAQGKSVLLAAGDTFRAAAREQLQAWGERNNVTVISQTTGDSAAVCFDAVQAAKARGIDIVLADTAGRLPTQLHL
MEEIKKVKRVLQKAMPDAPHEIIVVLDANIGQNAVNQVKAFDDALGLTGLIVTKLDGTAKGGILAALASDRPVPVRYIGV
GEGIDDLRPFDARAFVDALLD

Nucleotide

• Length: 1266 bp

>NTDB_id=47843 NMAA_RS00215 WP_002220091.1 36986..38251(+) (pilA) [Neisseria meningitidis WUE 2594]
ATGTTCAGCTTCTTCCGTCGCAAGAAAAAACAGGAAACGCCGGCTCTCGAGGAGGCTCAAATTCAGGAAACCGCAGCAAA
AGCAGAGTCCGAAACCGATCAAGTAATTGAAAATATTAAAGAAGATGCTGAATCTTTAGCAGAAAGCGTCAAAGGGCAGG
TCGAATCTGCCGTTGAAACCGTCAGCGGTGCGGTTGAACAGGTAAAGGAAACCGTTGCCGAGATGCTGTCTGAAGCAGAG
GAAGCGGCGGAAAAAGCAGCGGAACAAGTCGAAGCGGCAAAAGAAGCCATTGCCGAAACCGTCGGCGAGGCTGTCGGGCA
AGTTCAAGAAGCCGTTGCGACAACTGAAGAACACAAGCTCGGTTGGGCGGCGCGTTTGAAACAAGGTTTGACCAAATCGC
GCGACAAAATGGCGAAATCGCTGGCGGGCGTGTTCGGCGGCGGACAAATCGACGAAGATTTGTACGAAGAGCTGGAAACC
GTGCTGATTACCAGCGACATGGGCATGGAAGCCACCGAATACCTGATGAAAGACGTGCGCGACCGCGTCAGCCTCAAAGG
GCTGAAAGACGGCAACGAATTGCGCGGCGCGTTGAAAGAAGCCTTGTACGACCTGATTAAGCCTCTGGAGAAACCTTTGG
TTTTGCCCGAAACCAAAGAGCCGTTTGTCATCATGCTTGCCGGCATCAACGGCGCGGGCAAAACCACGTCTATCGGTAAA
CTCGCCAAATATTTCCAAGCGCAGGGCAAATCTGTGCTGCTTGCCGCCGGCGACACCTTCCGCGCCGCCGCCCGTGAGCA
GCTTCAAGCTTGGGGCGAACGCAACAACGTAACCGTGATTTCGCAAACCACGGGCGATTCCGCCGCCGTGTGCTTCGATG
CCGTCCAAGCCGCCAAAGCGCGCGGCATCGACATTGTGCTGGCCGACACCGCCGGCCGCCTGCCCACGCAGCTTCATTTG
ATGGAAGAAATCAAAAAAGTGAAACGCGTGCTGCAAAAAGCCATGCCCGACGCGCCGCACGAAATCATCGTCGTGCTTGA
TGCCAACATCGGGCAAAACGCCGTCAACCAAGTCAAAGCCTTTGACGACGCATTAGGGCTGACCGGTTTAATCGTGACCA
AACTCGACGGCACGGCAAAAGGCGGCATCCTCGCCGCGCTTGCCTCCGACCGCCCCGTCCCCGTCCGCTATATCGGCGTG
GGCGAAGGCATAGACGATTTGCGCCCGTTTGACGCGCGCGCGTTTGTGGACGCACTGCTGGATTGA

Domains

Predicted by InterproScan.

• SRP54-type protein, GTPase domain (SRP54) (221-420)

• SRP54-type protein, helical bundle domain (SRP54_N) (136-202)

3D structure

• AlphaFold DB: X5EMG2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
pilA	Neisseria gonorrhoeae MS11	93.824	100	0.938