Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilR   Type   Regulator
Locus tag   H9L17_RS10855 Genome accession   NZ_CP060711
Coordinates   2356292..2357734 (-) Length   480 a.a.
NCBI ID   WP_187569469.1    Uniprot ID   A0A7G9QQS6
Organism   Thermomonas brevis strain KACC 16975     
Function   regulate pilin expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2343854..2355891 2356292..2357734 flank 401


Gene organization within MGE regions


Location: 2343854..2357734
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H9L17_RS10790 (H9L17_10785) - 2343875..2345011 (+) 1137 WP_246455076.1 glycosyltransferase family 4 protein -
  H9L17_RS10795 (H9L17_10790) - 2345390..2346304 (-) 915 WP_187569457.1 glycosyltransferase -
  H9L17_RS10800 (H9L17_10795) - 2346460..2347380 (-) 921 WP_187569458.1 hypothetical protein -
  H9L17_RS10805 (H9L17_10800) - 2347499..2348218 (-) 720 WP_187569459.1 class I SAM-dependent methyltransferase -
  H9L17_RS10810 (H9L17_10805) - 2348215..2349039 (-) 825 WP_187569460.1 methyltransferase, TIGR04325 family -
  H9L17_RS10815 (H9L17_10810) - 2349296..2350645 (-) 1350 WP_187569461.1 oligosaccharide flippase family protein -
  H9L17_RS10820 (H9L17_10815) - 2350747..2350947 (-) 201 WP_187569462.1 integrase core domain-containing protein -
  H9L17_RS10825 (H9L17_10820) - 2351271..2351636 (-) 366 WP_187569463.1 SGNH hydrolase domain-containing protein -
  H9L17_RS10830 (H9L17_10825) - 2351820..2352416 (-) 597 WP_187569464.1 acyltransferase -
  H9L17_RS10835 (H9L17_10830) - 2352507..2353064 (-) 558 WP_187569465.1 acyltransferase family protein -
  H9L17_RS10840 (H9L17_10835) - 2352970..2355015 (-) 2046 WP_187569466.1 hypothetical protein -
  H9L17_RS15925 - 2355328..2355420 (-) 93 Protein_2135 prepilin-type N-terminal cleavage/methylation domain-containing protein -
  H9L17_RS16065 - 2355802..2355891 (-) 90 Protein_2136 prepilin-type N-terminal cleavage/methylation domain-containing protein -
  H9L17_RS10855 (H9L17_10850) pilR 2356292..2357734 (-) 1443 WP_187569469.1 sigma-54 dependent transcriptional regulator Regulator

Sequence

Protein


Download         Length: 480 a.a.        Molecular weight: 51544.29 Da        Isoelectric Point: 7.0184

>NTDB_id=477949 H9L17_RS10855 WP_187569469.1 2356292..2357734(-) (pilR) [Thermomonas brevis strain KACC 16975]
MSTPARSANNAPICALIVDDERDIRELLVLTLGRMGLKCDTASSLHDARALLRHNQYALCLTDMRLSDGSGIELVQEISQ
LYAQTPVAMITAFGNQEAAVGALKAGAFDFVSKPVDLAVLRGLVQHALKLAPSSARPMGEAAAKPAAASAVAARLLGQSA
AMAELRSTLAKVARSQAPVYIAGESGVGKELVARTIHDEGARAAGPFVPVNCGAIPAELMESEFFGHKKGSFTGAHADKT
GLFQAAEGGTLFLDEIAELPMSMQVKLLRAIQEKSVRPVGANSEVPVDVRILSATHKNLAALVEEGRFRHDLYYRINVIE
LRVPPLRNRREDLPVLVDAILTRLAAAQGRPRPMLHADAMEALAHYTFPGNVRELENILERAFALADDDGIRASDLRLPE
ARPAAPMPAQADAAAASLDPTLIDPRESAASALPSFIEEIERKAIEQALQDNRFNKTKTAAQLGITFRALRYKLKKLGID

Nucleotide


Download         Length: 1443 bp        

>NTDB_id=477949 H9L17_RS10855 WP_187569469.1 2356292..2357734(-) (pilR) [Thermomonas brevis strain KACC 16975]
ATGAGTACCCCCGCCCGCAGTGCCAACAACGCCCCGATTTGCGCCCTGATCGTCGACGACGAGCGCGACATCCGCGAACT
GCTGGTGCTCACCCTGGGGCGGATGGGACTGAAGTGCGACACCGCCTCGTCACTGCACGACGCCCGCGCCCTGCTCCGCC
ACAACCAGTACGCGCTGTGCCTGACCGACATGCGCCTGAGCGACGGCTCCGGCATCGAACTGGTGCAGGAAATCTCCCAG
CTCTACGCGCAGACGCCGGTGGCGATGATCACCGCCTTCGGCAACCAGGAAGCCGCGGTCGGCGCGCTCAAGGCCGGCGC
CTTCGATTTCGTCAGCAAGCCGGTCGACCTGGCGGTGCTGCGCGGCCTGGTGCAGCACGCATTGAAGCTGGCCCCGTCGT
CGGCGCGCCCCATGGGCGAGGCAGCGGCCAAGCCCGCCGCCGCCAGCGCGGTTGCCGCACGCCTGCTGGGTCAATCGGCG
GCGATGGCCGAACTGCGCTCCACGCTGGCGAAGGTCGCCCGCAGTCAGGCCCCCGTCTACATCGCCGGCGAATCCGGCGT
CGGCAAGGAACTGGTCGCCCGCACCATCCACGACGAAGGCGCGCGCGCCGCCGGCCCGTTCGTGCCGGTCAACTGCGGCG
CTATTCCCGCCGAGCTGATGGAAAGCGAATTTTTCGGCCACAAGAAGGGCAGCTTCACCGGCGCCCACGCCGACAAGACC
GGCCTGTTCCAGGCGGCCGAGGGCGGCACCCTGTTCCTGGACGAGATCGCCGAACTGCCGATGTCCATGCAGGTCAAGCT
GCTGCGCGCCATCCAGGAGAAATCGGTGCGCCCGGTGGGCGCCAACAGCGAAGTCCCGGTGGACGTGCGCATCCTTTCGG
CCACCCACAAGAACCTGGCCGCGCTGGTCGAGGAAGGCCGCTTCCGCCACGACCTCTACTACCGCATCAACGTGATCGAG
CTGCGGGTGCCGCCGCTGCGCAACCGCCGCGAAGACCTGCCGGTGCTGGTGGACGCCATCCTGACCCGGCTCGCCGCCGC
CCAGGGCCGCCCGCGCCCGATGCTGCACGCCGACGCCATGGAGGCGCTGGCCCACTACACCTTCCCCGGCAACGTGCGCG
AACTGGAGAACATCCTGGAACGCGCCTTCGCCCTGGCCGACGACGACGGCATCCGCGCCTCCGACCTGCGCCTGCCGGAA
GCCCGCCCCGCCGCACCGATGCCGGCCCAGGCCGACGCCGCGGCCGCCAGCCTCGACCCCACCCTGATCGACCCGCGCGA
ATCCGCCGCCAGCGCCCTGCCCAGCTTCATCGAGGAAATCGAGCGCAAGGCCATCGAGCAGGCGCTGCAGGACAACCGCT
TCAACAAGACCAAGACCGCCGCGCAGCTGGGCATCACCTTCCGCGCGCTGCGGTACAAGCTGAAGAAGCTGGGGATCGAC
TGA

Domains

Predicted by InterproScan.

Bacterial regulatory protein, Fis family (HTH_8)

(437-477)

Sigma-54 interaction domain (Sigma54_activat)

(155-321)

Response regulator receiver domain (Response_reg)

(16-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7G9QQS6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilR Pseudomonas aeruginosa PAK

61.456

97.292

0.598
  pilR Acinetobacter baumannii strain A118

46.862

99.583

0.467