Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SPN032672_RS08245 Genome accession   NC_021003
Coordinates   1540004..1540636 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae SPN032672     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1535004..1545636
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN032672_RS08220 mvaD 1535281..1536234 (+) 954 WP_000373452.1 diphosphomevalonate decarboxylase -
  SPN032672_RS08225 - 1536221..1537228 (+) 1008 WP_000562440.1 phosphomevalonate kinase -
  SPN032672_RS08230 fni 1537212..1538222 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  SPN032672_RS08235 liaF 1538300..1538998 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  SPN032672_RS08240 - 1538995..1539990 (+) 996 WP_000743686.1 sensor histidine kinase -
  SPN032672_RS08245 vraR 1540004..1540636 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  SPN032672_RS14010 - 1540637..1540879 (+) 243 WP_001854757.1 DNA alkylation repair protein -
  SPN032672_RS13795 - 1540861..1541403 (+) 543 Protein_1540 DNA alkylation repair protein -
  SPN032672_RS08265 - 1541553..1541792 (+) 240 WP_000754502.1 hypothetical protein -
  SPN032672_RS08270 cbpG 1541873..1542463 (+) 591 Protein_1542 choline-binding protein CbpG -
  SPN032672_RS08275 - 1542765..1543124 (+) 360 WP_000378123.1 tyrosine-type recombinase/integrase -
  SPN032672_RS08280 tig 1543318..1544601 (+) 1284 WP_000116462.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=47743 SPN032672_RS08245 WP_000698434.1 1540004..1540636(+) (vraR) [Streptococcus pneumoniae SPN032672]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=47743 SPN032672_RS08245 WP_000698434.1 1540004..1540636(+) (vraR) [Streptococcus pneumoniae SPN032672]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41