Detailed information NTG0477038

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: H7796_RS02250
• Genome accession: NZ_CP060640
• Coordinates: 431749..433101 (+)
• Length: 450 a.a.
• NCBI ID: WP_002990673.1
• Uniprot ID: A0A660A508
• Organism: Streptococcus pyogenes strain TSPY764
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 426749..438101

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7796_RS02225 (H7796_02240)	-	426898..427047 (+)	150	WP_002994198.1	hypothetical protein	-
H7796_RS02230 (H7796_02245)	-	427442..428590 (+)	1149	WP_228631453.1	acetyl-CoA C-acyltransferase	-
H7796_RS02235 (H7796_02250)	-	428547..429794 (+)	1248	WP_228631455.1	AMP-binding protein	-
H7796_RS02240 (H7796_02255)	-	429850..430884 (+)	1035	WP_228631457.1	DUF3114 domain-containing protein	-
H7796_RS02245 (H7796_02260)	vicR	431046..431756 (+)	711	WP_002985645.1	response regulator YycF	Regulator
H7796_RS02250 (H7796_02265)	vicK	431749..433101 (+)	1353	WP_002990673.1	cell wall metabolism sensor histidine kinase VicK	Regulator
H7796_RS02255 (H7796_02270)	vicX	433105..433914 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
H7796_RS02260 (H7796_02275)	rnc	434346..435038 (+)	693	WP_002985639.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=477038 H7796_RS02250 WP_002990673.1 431749..433101(+) (vicK) [Streptococcus pyogenes strain TSPY764]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=477038 H7796_RS02250 WP_002990673.1 431749..433101(+) (vicK) [Streptococcus pyogenes strain TSPY764]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTATCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

3D structure

• AlphaFold DB: A0A660A508

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64