Detailed information NTG0475217

Bioinformatically predicted

Overview

• Name: dsbA2
• Type: Machinery gene
• Locus tag: H7969_RS08140
• Genome accession: NZ_CP060280
• Coordinates: 1620929..1621624 (-)
• Length: 231 a.a.
• NCBI ID: WP_002215704.1
• Uniprot ID: Q7DDR6
• Organism: Neisseria meningitidis strain LNP24198
• Function: DNA binding and uptake; interact with PilQ (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1605655..1622454	1620929..1621624	within	0

Gene organization within MGE regions

Location: 1605655..1622454

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7969_RS08060 (H7969_08060)	-	1606957..1607202 (-)	246	WP_002224299.1	hypothetical protein	-
H7969_RS08065 (H7969_08065)	-	1607314..1607742 (+)	429	WP_002212270.1	CopD family protein	-
H7969_RS08070 (H7969_08070)	-	1607754..1608230 (+)	477	WP_002224298.1	CYTH domain-containing protein	-
H7969_RS08075 (H7969_08075)	-	1608580..1609068 (-)	489	WP_002224297.1	dihydrofolate reductase	-
H7969_RS08080 (H7969_08080)	aroG	1609136..1610191 (-)	1056	WP_002216371.1	3-deoxy-7-phosphoheptulonate synthase AroG	-
H7969_RS08085 (H7969_08085)	-	1610353..1610580 (-)	228	WP_153310284.1	hypothetical protein	-
H7969_RS08090 (H7969_08090)	-	1610854..1611111 (+)	258	WP_002247771.1	hypothetical protein	-
H7969_RS08095 (H7969_08095)	-	1611160..1611264 (-)	105	Protein_1579	IS1595 family transposase	-
H7969_RS11605	-	1611436..1611570 (-)	135	WP_256864600.1	hypothetical protein	-
H7969_RS08100 (H7969_08100)	comE	1611939..1612403 (-)	465	WP_162818804.1	ComEA family DNA-binding protein	Machinery gene
H7969_RS08130 (H7969_08130)	-	1618202..1619008 (-)	807	WP_002221447.1	inner membrane protein YpjD	-
H7969_RS08135 (H7969_08135)	ffh	1619228..1620598 (+)	1371	WP_002221448.1	signal recognition particle protein	-
H7969_RS08140 (H7969_08140)	dsbA2	1620929..1621624 (-)	696	WP_002215704.1	thiol:disulfide interchange protein DsbA/DsbL	Machinery gene
H7969_RS08145 (H7969_08145)	-	1621795..1622454 (-)	660	WP_002218694.1	NYN domain-containing protein	-

Sequence

Protein

• Length: 231 a.a.
• Molecular weight: 25419.90 Da
• Isoelectric Point: 5.1502

>NTDB_id=475217 H7969_RS08140 WP_002215704.1 1620929..1621624(-) (dsbA2) [Neisseria meningitidis strain LNP24198]
MKLKTLALTSLTLLALAACSKQAETSVPADSAQSSSSAPAAPAELNEGVNYTVLSTPIPQQQAGKIEVLEFFGYFCPHCA
HLEPVLSEHIKTFKDDTYMRREHVVWGDEMKPLARLAAAVEMAGESDKANSHIFDAMVNQKINLADTDTLKKWLSEQTAF
DGKKVLAAFEAPESQARAAQMEELTNKFQISGTPTVIVGGKYQVEFKDWQSGMTTIDQLVDKVREEQKKPQ

Nucleotide

• Length: 696 bp

>NTDB_id=475217 H7969_RS08140 WP_002215704.1 1620929..1621624(-) (dsbA2) [Neisseria meningitidis strain LNP24198]
ATGAAACTGAAAACCTTAGCTTTGACTTCATTGACCCTGTTGGCATTGGCCGCTTGTAGCAAACAGGCTGAAACCAGTGT
TCCGGCAGACAGCGCCCAAAGCAGCTCATCTGCTCCGGCAGCCCCTGCTGAGTTGAACGAAGGTGTGAACTACACTGTAT
TGTCTACGCCTATTCCGCAACAGCAGGCCGGTAAAATCGAAGTATTGGAATTTTTCGGCTACTTCTGCCCGCATTGCGCC
CATCTTGAGCCGGTCTTGAGCGAGCACATCAAAACGTTTAAAGACGATACCTATATGCGCCGGGAGCATGTCGTGTGGGG
TGATGAAATGAAACCTTTGGCACGTTTGGCGGCCGCAGTGGAAATGGCCGGTGAATCAGATAAAGCCAACAGCCATATTT
TCGATGCGATGGTTAATCAAAAAATCAATCTGGCCGATACCGATACCCTGAAAAAATGGCTGTCCGAGCAAACAGCGTTT
GACGGCAAAAAAGTATTGGCTGCATTTGAGGCTCCTGAAAGCCAAGCGCGTGCGGCTCAAATGGAAGAGTTGACCAATAA
ATTCCAAATCAGCGGCACACCGACTGTGATTGTCGGCGGCAAATACCAAGTTGAATTTAAAGACTGGCAGTCTGGTATGA
CCACGATTGACCAGTTGGTGGATAAAGTACGCGAAGAGCAGAAAAAGCCGCAATAA

Domains

Predicted by InterproScan.

• Thioredoxin (Thioredoxin_4) (65-212)

3D structure

• AlphaFold DB: Q7DDR6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dsbA2	Neisseria meningitidis MC58	100	100	1
dsbA1	Neisseria meningitidis MC58	71.245	100	0.719