Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   H6X75_RS10100 Genome accession   NZ_CP060156
Coordinates   1992911..1993852 (-) Length   313 a.a.
NCBI ID   WP_000249556.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700608     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1987911..1998852
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H6X75_RS10060 (H6X75_10050) comYH 1988398..1989351 (-) 954 WP_000345117.1 class I SAM-dependent methyltransferase Machinery gene
  H6X75_RS10065 (H6X75_10055) - 1989412..1990005 (-) 594 Protein_1971 methyltransferase domain-containing protein -
  H6X75_RS10070 (H6X75_10060) comGG/cglG 1990142..1990555 (-) 414 WP_000265630.1 competence type IV pilus minor pilin ComGG Machinery gene
  H6X75_RS10075 (H6X75_10065) comGF/cglF 1990533..1990994 (-) 462 WP_000250530.1 competence type IV pilus minor pilin ComGF Machinery gene
  H6X75_RS10080 (H6X75_10070) comGE/cglE 1990957..1991259 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  H6X75_RS10085 (H6X75_10075) comGD/cglD 1991222..1991626 (-) 405 WP_000588006.1 competence type IV pilus minor pilin ComGD Machinery gene
  H6X75_RS10090 (H6X75_10080) comGC/cglC 1991619..1991945 (-) 327 WP_000738638.1 comG operon protein ComGC Machinery gene
  H6X75_RS10095 (H6X75_10085) comGB/cglB 1991947..1992963 (-) 1017 WP_075270915.1 competence type IV pilus assembly protein ComGB Machinery gene
  H6X75_RS10100 (H6X75_10090) comGA/cglA/cilD 1992911..1993852 (-) 942 WP_000249556.1 competence type IV pilus ATPase ComGA Machinery gene
  H6X75_RS10105 (H6X75_10095) - 1993927..1994292 (-) 366 WP_000286415.1 DUF1033 family protein -
  H6X75_RS10110 (H6X75_10100) - 1994443..1995501 (-) 1059 WP_000649471.1 zinc-dependent alcohol dehydrogenase family protein -
  H6X75_RS10115 (H6X75_10105) nagA 1995664..1996815 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  H6X75_RS10120 (H6X75_10110) - 1996968..1998785 (-) 1818 WP_001220846.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35534.46 Da        Isoelectric Point: 6.0083

>NTDB_id=474191 H6X75_RS10100 WP_000249556.1 1992911..1993852(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain PZ900700608]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFASRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=474191 H6X75_RS10100 WP_000249556.1 1992911..1993852(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain PZ900700608]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCCAAGTT
AGATGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAGCAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae D39

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae R6

99.042

100

0.99
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

99.042

100

0.99
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

96.805

100

0.968
  comYA Streptococcus gordonii str. Challis substr. CH1

78.387

99.042

0.776
  comYA Streptococcus mutans UA159

66.238

99.361

0.658
  comYA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364