Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   H6X75_RS04515 Genome accession   NZ_CP060156
Coordinates   892758..893408 (+) Length   216 a.a.
NCBI ID   WP_000387331.1    Uniprot ID   A0A0E7VQD3
Organism   Streptococcus pneumoniae strain PZ900700608     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 887758..898408
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H6X75_RS04485 (H6X75_04470) - 888241..888456 (+) 216 WP_001232082.1 YozE family protein -
  H6X75_RS04490 (H6X75_04475) - 888542..889510 (+) 969 WP_000658183.1 PhoH family protein -
  H6X75_RS04495 (H6X75_04485) - 889703..890203 (+) 501 WP_000566983.1 GNAT family N-acetyltransferase -
  H6X75_RS04500 (H6X75_04490) - 890206..890532 (+) 327 Protein_897 TfoX/Sxy family protein -
  H6X75_RS04505 ald 890833..891944 (-) 1112 Protein_898 alanine dehydrogenase -
  H6X75_RS04510 (H6X75_04510) - 892121..892690 (+) 570 WP_000443744.1 GNAT family N-acetyltransferase -
  H6X75_RS04515 (H6X75_04515) comEA/celA/cilE 892758..893408 (+) 651 WP_000387331.1 ComEA family DNA-binding protein Machinery gene
  H6X75_RS04520 (H6X75_04520) comEC/celB 893392..895632 (+) 2241 WP_000942387.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  H6X75_RS04525 (H6X75_04525) - 895774..895998 (+) 225 WP_001813351.1 hypothetical protein -
  H6X75_RS04530 (H6X75_04530) - 896030..896617 (+) 588 WP_000945253.1 ABC transporter ATP-binding protein -
  H6X75_RS04535 (H6X75_04535) - 896621..897802 (+) 1182 WP_000655954.1 hypothetical protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23203.57 Da        Isoelectric Point: 5.5171

>NTDB_id=474147 H6X75_RS04515 WP_000387331.1 892758..893408(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700608]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=474147 H6X75_RS04515 WP_000387331.1 892758..893408(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700608]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E7VQD3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae D39

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae R6

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.685

100

0.977
  comEA/celA/cilE Streptococcus mitis NCTC 12261

96.296

100

0.963
  comEA/celA/cilE Streptococcus mitis SK321

90.741

100

0.907
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366
  comEA Latilactobacillus sakei subsp. sakei 23K

33.476

100

0.361