Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   R2866_RS00705 Genome accession   NC_017451
Coordinates   140984..142321 (+) Length   445 a.a.
NCBI ID   WP_005649302.1    Uniprot ID   -
Organism   Haemophilus influenzae R2866     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 135984..147321
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R2866_RS00680 (R2866_0135) - 136049..138643 (-) 2595 WP_005649307.1 penicillin-binding protein 1A -
  R2866_RS00685 (R2866_0136) comA 138742..139539 (+) 798 WP_005649306.1 pilus assembly protein PilM Machinery gene
  R2866_RS00690 (R2866_0137) comB 139540..140046 (+) 507 WP_005649305.1 competence protein ComB Machinery gene
  R2866_RS00695 (R2866_0138) comC 140043..140564 (+) 522 WP_005649304.1 competence protein ComC Machinery gene
  R2866_RS00700 (R2866_0139) comD 140561..140974 (+) 414 WP_005649303.1 pilus assembly protein PilP Machinery gene
  R2866_RS00705 (R2866_0140) comE 140984..142321 (+) 1338 WP_005649302.1 type IV pilus secretin PilQ family protein Machinery gene
  R2866_RS00710 (R2866_0141) - 142334..143020 (+) 687 WP_005649301.1 ComF family protein -
  R2866_RS00715 (R2866_0142) nfuA 143096..143692 (+) 597 WP_005649300.1 Fe-S biogenesis protein NfuA -
  R2866_RS00720 (R2866_0143) nudC 143759..144553 (+) 795 WP_005666520.1 NAD(+) diphosphatase -
  R2866_RS00725 (R2866_0144) - 144589..145179 (+) 591 WP_005649296.1 YjaG family protein -
  R2866_RS00730 (R2866_0145) - 145319..145591 (+) 273 WP_005630954.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 49184.43 Da        Isoelectric Point: 7.8654

>NTDB_id=47252 R2866_RS00705 WP_005649302.1 140984..142321(+) (comE) [Haemophilus influenzae R2866]
MKKYFLKCGYFLVCFCLPLIVFANPKTDNERFFIRLSQAPLAQTLEQLAFQQDVNLVMGERLEGNISLKLNNIDMPRLLK
IIAKSKHLTLNKDDGVYYLNGSQSGKGQVAGNLTTNEPHLVSHTVKLHFAKASELMKSLTTGSGSLLSPDGSITFDDRSN
LLVIQDEPRSVQNIKKLIAEMDKPIEQIAIEARIVTITDESLKELGVRWGIFNPTENARRVAGSLTGNSFENIADNLNVN
FATTTTPAGSIALQVAKINGRLLDLELSALERENNVEIIASPRLLTTNKKSASIKQGTEIPYIVSNTRNDTQSVEFREAV
LGLEVTPHISKDNNILLDLLVSQNSPGSRVAYGQNEVVSIDKQEINTQVFAKDGETIVLGGVFHDTITKSEDKVPLLGDI
PVIKRLFSKESERHQKRELVIFVTPHILKAGETLEALKQKSAGKK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=47252 R2866_RS00705 WP_005649302.1 140984..142321(+) (comE) [Haemophilus influenzae R2866]
ATGAAGAAATATTTTTTAAAGTGCGGTTATTTTTTAGTGTGTTTTTGTTTGCCATTAATCGTTTTTGCTAATCCTAAAAC
AGATAACGAACGTTTTTTTATTCGTTTATCGCAAGCACCTTTAGCTCAAACACTGGAGCAATTAGCTTTTCAACAAGATG
TGAATTTAGTGATGGGTGAGAGGTTAGAAGGCAATATTTCTTTGAAATTAAATAATATTGATATGCCACGTTTGCTAAAA
ATAATCGCAAAAAGTAAGCATCTTACTTTGAATAAAGATGATGGGGTTTATTATTTAAACGGCAGTCAATCTGGCAAAGG
TCAAGTTGCAGGAAATCTTACGACAAATGAACCGCACTTAGTCAGCCACACGGTAAAACTTCATTTTGCTAAAGCCTCTG
AATTAATGAAATCCTTAACAACAGGAAGTGGCTCTTTGCTTTCTCCCGATGGGAGCATTACCTTTGATGATCGCAGTAAT
TTGCTGGTTATTCAGGATGAACCTCGTTCCGTGCAAAATATCAAAAAACTGATTGCTGAAATGGATAAGCCTATTGAACA
GATCGCTATTGAAGCACGAATTGTGACAATTACGGATGAGAGTTTGAAAGAACTTGGCGTTCGGTGGGGGATTTTTAATC
CAACTGAAAATGCAAGACGAGTTGCGGGCAGCCTTACAGGCAATAGCTTTGAAAATATTGCGGATAATCTTAATGTAAAT
TTTGCGACAACGACGACACCTGCTGGCTCTATAGCATTACAAGTCGCCAAAATTAATGGGCGATTGCTTGATTTAGAATT
GAGTGCGTTGGAGCGTGAAAATAATGTAGAAATTATTGCAAGTCCTCGCTTACTCACTACCAATAAGAAAAGTGCGAGCA
TTAAACAGGGGACAGAAATTCCTTACATCGTGAGTAATACTCGTAACGATACGCAATCTGTCGAGTTTCGTGAGGCAGTA
CTTGGTTTGGAAGTGACGCCACATATTTCTAAAGATAACAATATCTTACTTGATTTATTGGTAAGTCAAAATTCCCCTGG
TTCTCGTGTCGCTTATGGACAAAATGAGGTGGTTTCTATTGATAAGCAAGAAATTAATACTCAGGTTTTTGCCAAAGATG
GGGAAACCATTGTGCTTGGCGGCGTATTTCACGACACAATCACGAAAAGTGAAGATAAAGTGCCATTGCTTGGCGATATA
CCCGTTATTAAACGATTATTTAGCAAAGAAAGTGAACGACATCAAAAACGTGAGCTCGTGATTTTCGTTACGCCACATAT
TTTAAAAGCAGGAGAAACGTTAGAGGCGTTGAAACAAAAAAGTGCGGGGAAAAAATAA

Domains

Predicted by InterproScan.

Bacterial type II and III secretion system protein (Secretin)

(269-429)

Bacterial type II/III secretion system short domain (Secretin_N)

(123-187)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Haemophilus influenzae 86-028NP

99.101

100

0.991
  comE Haemophilus influenzae Rd KW20

97.978

100

0.98
  comE Glaesserella parasuis strain SC1401

52.235

95.506

0.499
  pilQ Vibrio campbellii strain DS40M4

42.959

94.157

0.404
  pilQ Vibrio cholerae O1 biovar El Tor strain E7946

42.233

92.584

0.391
  pilQ Vibrio cholerae strain A1552

42.233

92.584

0.391

Multiple sequence alignment