Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   HMPREF0772_RS02260 Genome accession   NC_017342
Coordinates   470979..472328 (+) Length   449 a.a.
NCBI ID   WP_000815651.1    Uniprot ID   A0A8F2DEH1
Organism   Staphylococcus aureus subsp. aureus TCH60     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 465820..480743 470979..472328 within 0


Gene organization within MGE regions


Location: 465820..480743
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0772_RS15340 (HMPREF0772_10423) - 466519..466968 (-) 450 WP_014532934.1 helix-turn-helix domain-containing protein -
  HMPREF0772_RS02245 (HMPREF0772_10424) - 467423..468469 (+) 1047 WP_001042025.1 hypothetical protein -
  HMPREF0772_RS02250 (HMPREF0772_10425) ssb 468662..468958 (+) 297 WP_000273825.1 cassette chromosome ssDNA-binding protein -
  HMPREF0772_RS02255 (HMPREF0772_10426) cch1 468958..470745 (+) 1788 WP_000122624.1 cassette chromosome replicative helicase -
  HMPREF0772_RS02260 (HMPREF0772_10427) ccrA 470979..472328 (+) 1350 WP_000815651.1 cassette chromosome recombinase CcrA Machinery gene
  HMPREF0772_RS02265 (HMPREF0772_10428) ccrB 472350..473978 (+) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  HMPREF0772_RS02270 (HMPREF0772_10429) - 474500..474850 (+) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  HMPREF0772_RS02275 (HMPREF0772_10430) - 474937..475248 (+) 312 WP_000700851.1 DUF960 family protein -
  HMPREF0772_RS02280 (HMPREF0772_10431) - 475263..475769 (+) 507 WP_001092189.1 DUF1643 domain-containing protein -
  HMPREF0772_RS02285 (HMPREF0772_10432) - 475818..477428 (+) 1611 Protein_432 IS1182 family transposase -
  HMPREF0772_RS02290 (HMPREF0772_10433) - 477419..477664 (-) 246 Protein_433 type I restriction enzyme endonuclease domain-containing protein -
  HMPREF0772_RS02295 (HMPREF0772_10434) - 477651..478637 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  HMPREF0772_RS02300 (HMPREF0772_10435) mecA 478734..480743 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52626.34 Da        Isoelectric Point: 10.0062

>NTDB_id=46452 HMPREF0772_RS02260 WP_000815651.1 470979..472328(+) (ccrA) [Staphylococcus aureus subsp. aureus TCH60]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYRVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHILTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQAMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=46452 HMPREF0772_RS02260 WP_000815651.1 470979..472328(+) (ccrA) [Staphylococcus aureus subsp. aureus TCH60]
ATGAAACAAGTTATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACACAATTAATTCAACAAGGACAATGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
TTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATATCGTGTTCATATCTTAAGTGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGATTATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACATATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATAAATGGGCATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAGCCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-248)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.327

100

0.973
  ccrA Staphylococcus aureus COL

75.056

100

0.751

Multiple sequence alignment