Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   JHX98_RS04465 Genome accession   NZ_CP067010
Coordinates   851674..853470 (+) Length   598 a.a.
NCBI ID   WP_011888904.1    Uniprot ID   A2REN0
Organism   Streptococcus pyogenes strain iGAS376     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 846674..858470
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JHX98_RS04450 (JHX98_04450) - 848232..849020 (+) 789 WP_011888907.1 response regulator -
  JHX98_RS04455 (JHX98_04455) - 849014..850060 (+) 1047 WP_011888906.1 extracellular solute-binding protein -
  JHX98_RS04460 (JHX98_04460) - 850175..851572 (+) 1398 WP_011888905.1 NAD-dependent succinate-semialdehyde dehydrogenase -
  JHX98_RS04465 (JHX98_04465) uvrC 851674..853470 (+) 1797 WP_011888904.1 excinuclease ABC subunit UvrC Machinery gene
  JHX98_RS04470 (JHX98_04470) - 853655..854257 (+) 603 WP_002989923.1 nitroreductase family protein -
  JHX98_RS04475 (JHX98_04475) pepV 854382..855791 (+) 1410 WP_011888903.1 dipeptidase PepV -
  JHX98_RS04480 (JHX98_04480) mnmE 855859..857235 (-) 1377 WP_011888902.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
  JHX98_RS04485 (JHX98_04485) - 857325..858311 (-) 987 WP_200221126.1 IS30-like element IS1239 family transposase -

Sequence

Protein


Download         Length: 598 a.a.        Molecular weight: 68826.59 Da        Isoelectric Point: 9.6620

>NTDB_id=456971 JHX98_RS04465 WP_011888904.1 851674..853470(+) (uvrC) [Streptococcus pyogenes strain iGAS376]
MNELIKHKLELLPDSPGCYLHKDKEGTIIYVGKAKNLKKRVRSYFRGSHDTKTELLVSEIVDFEYIVTESDTEALLLEIN
LIQKNMPKYNIKLKDDKSYPFLKITNESFPRLVITRYIKKNDGLYFGPYPDSYTANEVKKLLDRIFPFKKCKNPINKVCF
YYHLGQCCAHTICHTDKAYWDRLIDDVKHFLNGKDDKIIEDLRSKMLAASEEMAFERAAEYRDLISGIATMRTKQRVMSK
DLQDRDIFGYYVDKGWMCVQVFFVRQGKLIQRDVNLFPYYNDAEEDFLTYMGQFYQDKQHFIPKEVFIPEAIDEELVAAI
VPTKIIKPKRGEKKQLVALATKNARVSLQQKFDLLEKDIKKTSGAIDNLGHLLGINKPVRIEAFDNSNIQGTSPVAAMVV
FVDGKPSKKDYRKFKIKTVVGPDDYASMREVLFRRYSRVKKEGLQAPNLIIVDGGVGQVNVAKDVIEKQLGLTIPVAGLQ
KNDKHQTHDLLFGNPLEVVPLPRRSEEFFLLHRIQDEVHRFAVTFHRQVRRKNSFSSTLDHISGLGPKRKQLLLRHFKTI
TAIASATSEEIQALGIPKTVVEAIQQQITDNKNDRSSP

Nucleotide


Download         Length: 1797 bp        

>NTDB_id=456971 JHX98_RS04465 WP_011888904.1 851674..853470(+) (uvrC) [Streptococcus pyogenes strain iGAS376]
ATGAACGAACTGATTAAACATAAACTAGAACTCTTACCAGACAGCCCTGGCTGTTACTTACATAAAGATAAAGAAGGAAC
TATTATCTATGTCGGTAAGGCTAAGAATTTGAAAAAACGCGTCCGGTCCTATTTTCGTGGGAGCCATGATACCAAAACAG
AGTTACTAGTATCTGAGATTGTAGATTTCGAATATATTGTAACAGAGTCAGATACCGAAGCGCTTTTGTTGGAAATTAAC
TTGATTCAAAAAAATATGCCTAAGTACAACATCAAGTTAAAAGATGATAAATCTTATCCCTTTCTCAAAATCACAAATGA
GTCTTTTCCTCGGTTAGTGATTACAAGATATATTAAGAAAAATGATGGATTGTACTTTGGGCCCTACCCAGATTCTTACA
CTGCTAATGAAGTTAAAAAGTTATTAGATAGGATTTTTCCATTTAAAAAGTGTAAAAATCCTATCAATAAGGTCTGTTTT
TATTACCATTTAGGCCAGTGCTGTGCTCATACCATTTGTCATACAGACAAGGCCTATTGGGATCGTTTAATTGATGATGT
TAAGCACTTTTTAAATGGTAAAGATGACAAAATTATTGAAGATCTTCGTTCTAAGATGTTAGCAGCTTCTGAAGAAATGG
CATTTGAACGTGCCGCTGAATATCGAGATTTGATTTCAGGTATTGCCACCATGCGCACCAAGCAGCGGGTGATGAGCAAG
GATTTGCAAGATAGAGATATCTTTGGCTATTATGTTGATAAGGGATGGATGTGTGTCCAAGTTTTCTTTGTGCGTCAAGG
GAAATTAATTCAGCGTGATGTTAACCTTTTTCCCTATTATAACGATGCAGAAGAAGATTTCTTAACTTATATGGGGCAAT
TTTACCAAGATAAACAGCATTTCATCCCTAAAGAAGTCTTTATTCCAGAAGCTATTGATGAAGAACTGGTAGCCGCTATT
GTGCCAACCAAAATCATCAAACCTAAACGCGGTGAAAAAAAACAACTGGTAGCTTTGGCTACTAAGAATGCTCGTGTTAG
TCTGCAACAAAAATTTGATTTATTAGAAAAAGATATTAAGAAAACTAGCGGTGCCATTGACAATCTAGGCCACTTGTTAG
GGATTAACAAGCCAGTCCGGATTGAGGCTTTTGATAATTCCAACATTCAAGGGACAAGCCCCGTAGCGGCTATGGTTGTT
TTTGTTGACGGGAAACCTAGTAAGAAAGATTATCGTAAATTTAAGATTAAAACAGTGGTGGGACCAGATGATTATGCCAG
TATGAGAGAAGTGCTTTTTCGAAGGTACAGTCGGGTGAAAAAGGAGGGACTGCAAGCTCCTAACTTGATTATTGTTGATG
GAGGCGTTGGACAAGTCAATGTGGCCAAAGATGTGATAGAAAAACAACTTGGACTCACTATTCCTGTTGCGGGACTTCAA
AAAAACGATAAGCACCAGACCCATGATTTGCTTTTTGGAAACCCGCTTGAAGTTGTACCGTTGCCGCGCCGTTCTGAAGA
GTTTTTCTTACTGCATCGGATTCAAGACGAAGTGCATCGCTTTGCAGTTACATTTCATAGACAAGTGCGACGTAAAAATT
CTTTTTCATCAACATTAGATCATATTTCAGGGCTTGGCCCAAAGCGAAAACAGTTATTACTAAGACACTTTAAAACCATA
ACAGCGATTGCATCAGCTACCTCTGAGGAGATTCAAGCTTTAGGTATACCTAAAACAGTAGTTGAAGCAATACAGCAACA
GATAACAGACAATAAAAATGATAGATCGTCTCCTTAA

Domains

Predicted by InterProScan.

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(373-523)

UvrB/uvrC motif (UVR)

(196-228)

GIY-YIG catalytic domain (GIY-YIG)

(17-90)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2REN0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

73.514

98.495

0.724
  uvrC Streptococcus pneumoniae R6

73.514

98.495

0.724
  uvrC Streptococcus pneumoniae D39

73.514

98.495

0.724