Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   JCR30_RS07185 Genome accession   NZ_CP067008
Coordinates   1391487..1392128 (-) Length   213 a.a.
NCBI ID   WP_011888671.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain iGAS426     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1386487..1397128
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JCR30_RS07160 (JCR30_07160) comFA/cflA 1386573..1387898 (-) 1326 WP_011184811.1 DEAD/DEAH box helicase Machinery gene
  JCR30_RS07165 (JCR30_07165) - 1387954..1388586 (+) 633 WP_009880468.1 YigZ family protein -
  JCR30_RS07170 (JCR30_07170) cysK 1388714..1389655 (+) 942 WP_011888673.1 cysteine synthase A -
  JCR30_RS07175 (JCR30_07175) - 1389673..1390050 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  JCR30_RS07180 (JCR30_07180) - 1390050..1391450 (-) 1401 WP_011888672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  JCR30_RS07185 (JCR30_07185) vraR 1391487..1392128 (-) 642 WP_011888671.1 response regulator transcription factor Regulator
  JCR30_RS07190 (JCR30_07190) - 1392121..1393125 (-) 1005 WP_002991890.1 sensor histidine kinase -
  JCR30_RS07195 (JCR30_07195) liaF 1393122..1393814 (-) 693 WP_011888670.1 cell wall-active antibiotics response protein LiaF -
  JCR30_RS07200 (JCR30_07200) pknB 1393937..1395835 (-) 1899 WP_011888669.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  JCR30_RS07205 (JCR30_07205) - 1395832..1396572 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23777.52 Da        Isoelectric Point: 5.1641

>NTDB_id=456804 JCR30_RS07185 WP_011888671.1 1391487..1392128(-) (vraR) [Streptococcus pyogenes strain iGAS426]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVLKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=456804 JCR30_RS07185 WP_011888671.1 1391487..1392128(-) (vraR) [Streptococcus pyogenes strain iGAS426]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTTAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGACATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(148-202)

Response regulator receiver domain (Response_reg)

(6-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.427

96.714

0.507
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385