Detailed information NTG0455231

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HUW54_RS09655
• Genome accession: NZ_CP054876
• Coordinates: 1962796..1963839 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Dresden-275757
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1957796..1968839

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HUW54_RS09625 (HUW54_09625)	-	1958218..1959474 (-)	1257	WP_001793428.1	aminopeptidase	-
HUW54_RS09630 (HUW54_09630)	-	1959477..1959677 (-)	201	WP_000180463.1	DUF1128 family protein	-
HUW54_RS09635 (HUW54_09635)	-	1959824..1960288 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HUW54_RS09640 (HUW54_09640)	-	1960295..1960570 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HUW54_RS09645 (HUW54_09645)	-	1960848..1962065 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
HUW54_RS09650 (HUW54_09650)	vraR	1962177..1962806 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
HUW54_RS09655 (HUW54_09655)	vraS	1962796..1963839 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HUW54_RS09660 (HUW54_09660)	liaF	1963836..1964537 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HUW54_RS09665 (HUW54_09665)	-	1964552..1964938 (-)	387	WP_001110179.1	hypothetical protein	-
HUW54_RS09670 (HUW54_09670)	map	1965155..1965913 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HUW54_RS09675 (HUW54_09675)	-	1966503..1967489 (+)	987	WP_000999718.1	aromatic acid exporter family protein	-
HUW54_RS09680 (HUW54_09680)	-	1967979..1968392 (-)	414	WP_001837236.1	hypothetical protein	-
HUW54_RS09685 (HUW54_09685)	-	1968421..1968532 (-)	112	Protein_1876	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=455231 HUW54_RS09655 WP_001017131.1 1962796..1963839(-) (vraS) [Staphylococcus aureus strain Dresden-275757]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=455231 HUW54_RS09655 WP_001017131.1 1962796..1963839(-) (vraS) [Staphylococcus aureus strain Dresden-275757]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1