NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	I6I02_RS00385	Genome accession	NZ_CP066093
Coordinates	74854..75597 (+)	Length	247 a.a.
NCBI ID	WP_002885796.1	Uniprot ID	-
Organism	Streptococcus salivarius strain FDAARGOS_1045
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 69854..80597

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6I02_RS00365 (I6I02_00365)	-	69960..71267 (+)	1308	WP_198463600.1	GHKL domain-containing protein	-
I6I02_RS00370 (I6I02_00370)	-	71323..72213 (+)	891	WP_198463601.1	histidine kinase	-
I6I02_RS00375 (I6I02_00375)	-	72235..73515 (+)	1281	WP_198463602.1	hypothetical protein	-
I6I02_RS00380 (I6I02_00380)	-	73536..74852 (+)	1317	WP_145517097.1	GHKL domain-containing protein	-
I6I02_RS00385 (I6I02_00385)	comE/blpR	74854..75597 (+)	744	WP_002885796.1	response regulator transcription factor	Regulator
I6I02_RS00390 (I6I02_00390)	-	76541..77740 (+)	1200	WP_037598503.1	argininosuccinate synthase	-
I6I02_RS00395 (I6I02_00395)	argH	78067..79452 (+)	1386	WP_002891959.1	argininosuccinate lyase	-
I6I02_RS00400 (I6I02_00400)	rnpA	79537..79872 (+)	336	WP_037600055.1	ribonuclease P protein component	-

Sequence

Protein

Download Length: 247 a.a. Molecular weight: 28536.83 Da Isoelectric Point: 6.7589

                                >NTDB_id=453724 I6I02_RS00385 WP_002885796.1 74854..75597(+) (comE/blpR) [Streptococcus salivarius strain FDAARGOS_1045]

MNIYILEDDLMQQTRISDIIRELVSEGTFSVRKLEVFSKPHKLLSSINEKGNHQVFLLDIDIDGERKKGLEVASEIRQQD

ANAVIIFVTTHSEFAPISFKYKVSALDFIDKTVSNAEFKQQLKQTLTFVNQKVGDVDDDEIFVFETAQSRIQVPMRDIYY

FATAVTPHKVMLITKTERLEFYANLGDITSVNKKLFSCHRSFLVNLDNISRIDKTQLMIYFENGDSCPVSRLKMKALLKK

WSEVKEH

Nucleotide

Download Length: 744 bp

                                >NTDB_id=453724 I6I02_RS00385 WP_002885796.1 74854..75597(+) (comE/blpR) [Streptococcus salivarius strain FDAARGOS_1045]

ATGAATATTTACATTTTAGAAGATGACTTAATGCAGCAAACACGTATTAGTGACATCATCAGAGAATTGGTTTCAGAGGG

CACGTTTTCCGTACGAAAACTTGAAGTTTTTTCTAAACCCCACAAACTATTGTCCAGTATCAACGAGAAGGGTAACCATC

AGGTTTTCCTTTTGGATATTGATATTGATGGTGAGCGAAAGAAGGGGCTAGAAGTCGCCTCAGAAATTCGCCAACAAGAT

GCTAATGCGGTTATTATTTTTGTGACAACTCACTCAGAGTTTGCACCGATTAGTTTTAAATACAAGGTTTCTGCGTTAGA

TTTTATTGATAAGACAGTTTCTAATGCAGAGTTCAAACAACAACTAAAACAAACATTGACTTTTGTAAATCAAAAAGTTG

GAGATGTGGATGATGATGAGATATTTGTGTTTGAAACAGCACAGTCTCGAATCCAAGTCCCTATGAGAGATATTTATTAT

TTTGCGACTGCGGTAACACCTCATAAGGTGATGCTGATTACTAAAACAGAGCGTTTGGAGTTTTATGCCAATCTTGGAGA

TATTACTTCGGTGAATAAAAAACTCTTTTCTTGTCATCGCTCGTTTTTAGTTAATTTGGATAATATTTCTCGTATTGATA

AGACTCAGTTGATGATTTACTTTGAAAATGGCGATTCTTGTCCAGTTTCACGTTTGAAAATGAAGGCCTTGCTTAAAAAA

TGGTCAGAGGTAAAAGAACATTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	47.5	97.166	0.462
comE/comE2	Streptococcus equinus JB1	42.857	99.19	0.425
comE/comE1	Streptococcus equinus JB1	40.496	97.976	0.397
comE/comE2	Streptococcus gordonii strain NCTC7865	37.402	100	0.385
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.402	100	0.385

Detailed information NTG0453724