Detailed information NTG0453246

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: I6I32_RS06120
• Genome accession: NZ_CP066041
• Coordinates: 1258474..1261008 (+)
• Length: 844 a.a.
• NCBI ID: WP_198464304.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain FDAARGOS_1075
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1253474..1266008

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6I32_RS06095 (I6I32_06095)	nrdI	1253540..1254010 (+)	471	WP_000724244.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
I6I32_RS06100 (I6I32_06100)	-	1254090..1255352 (-)	1263	WP_198464302.1	NRAMP family divalent metal transporter	-
I6I32_RS06105 (I6I32_06105)	-	1255551..1255796 (-)	246	WP_198464303.1	MarR family transcriptional regulator	-
I6I32_RS06110 (I6I32_06110)	argS	1256131..1257822 (-)	1692	WP_125384809.1	arginine--tRNA ligase	-
I6I32_RS06115 (I6I32_06115)	argR	1257977..1258423 (+)	447	WP_001231483.1	arginine repressor	-
I6I32_RS06120 (I6I32_06120)	hexA	1258474..1261008 (+)	2535	WP_198464304.1	DNA mismatch repair protein MutS	Machinery gene
I6I32_RS06125 (I6I32_06125)	-	1261049..1261507 (-)	459	WP_198464305.1	DUF3021 domain-containing protein	-
I6I32_RS06130 (I6I32_06130)	-	1261504..1261944 (-)	441	WP_198464306.1	LytTR family DNA-binding domain-containing protein	-
I6I32_RS06135 (I6I32_06135)	hexB	1262258..1264207 (+)	1950	WP_198464307.1	DNA mismatch repair endonuclease MutL	Machinery gene
I6I32_RS06140 (I6I32_06140)	-	1264361..1264858 (-)	498	WP_198464308.1	helix-turn-helix domain-containing protein	-

Sequence

Protein

• Length: 844 a.a.
• Molecular weight: 94623.12 Da
• Isoelectric Point: 4.8531

>NTDB_id=453246 I6I32_RS06120 WP_198464304.1 1258474..1261008(+) (hexA) [Streptococcus oralis strain FDAARGOS_1075]
MATEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAINAAQILEISLTSRNKNAENPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSLDCDGNQFGLAYMDLVTGDFYVTGLLYFTL
VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKEGFEDIHLLDPRLAAVEQAAASKLLQYVHRTQMRELNHLKP
VIYYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPALAYLIAQLDAIPELESLISAAIAP
EAPHVITEGGIIRTGFDETLDKYRRVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKA
TLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVSKYIQRLQALAQGIATIDVLQSLAVVAETQHLIRPEFG
EDSQIDIQKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKDSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLKNLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPAELLARADKILTQLENQGTESPAPMRETSA
VTEQMSLFDAPAEHPILAELAKLDVYNMTPMQAMNVLAELKQKL

Nucleotide

• Length: 2535 bp

>NTDB_id=453246 I6I32_RS06120 WP_198464304.1 1258474..1261008(+) (hexA) [Streptococcus oralis strain FDAARGOS_1075]
ATGGCAACAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAAAAACAATACCCAGATGCTTTTTTGCTTTT
TCGGATGGGTGATTTTTACGAGTTGTTCTATGAAGATGCAATTAATGCAGCGCAAATTTTAGAAATTTCCTTAACAAGTC
GGAATAAAAATGCAGAAAATCCGATACCCATGGCGGGCGTCCCCTATCATTCTGCCCAACAGTATATCGATGTTCTGATT
GAGCAGGGCTATAAAGTTGCCATTGCCGAACAGATGGAAGATCCCAAACAAGCGGTTGGTGTTGTCAAGCGAGAGGTGGT
CCAGGTCATCACACCTGGAACGGTCGTTGATAGCAGTAAGCCGGATAGTCAGAATAATTTCTTGGTTTCCTTAGATTGTG
ATGGCAATCAATTTGGTCTGGCTTATATGGATTTGGTGACGGGTGACTTTTATGTGACGGGGCTATTGTATTTCACGTTG
GTTTGTGGGGAAATCCGTAACCTAAAGGCGCGAGAAGTGGTGCTGGGTTATGACTTGTCTGAGGAAGAAGAACAAATCCT
CAGCCGTCAGATGAATCTGGTGCTTTCTTATGAGAAGGAAGGCTTTGAGGATATTCATTTACTGGATCCACGACTGGCAG
CTGTGGAGCAAGCGGCAGCTAGTAAGCTCCTCCAGTATGTTCACCGTACCCAGATGCGAGAATTGAACCATCTCAAACCA
GTTATCTACTATGAAATTAAAGATTTCTTGCAGATGGATTATGCGACCAAGGCTAGTCTGGATTTGGTTGAGAATGCCCG
TTCAGGCAAGAAGCAGGGGAGTCTTTTCTGGCTTTTGGATGAAACCAAAACAGCTATGGGCATGCGGCTCTTGCGCTCTT
GGATCCATCGTCCCTTGATTGATAAGGAACGAATCGTCCAACGTCAAGAGGTGGTGCAGGTCTTTCTTGACCACTTCTTT
GAGCGTAGTGATTTGACAGACAGTCTCAAGGGTGTTTATGACATCGAACGTTTGGCTAGTCGGGTTTCTTTTGGCAAGAC
CAATCCAAAGGATCTCTTGCAACTGGCGACTACCTTATCTAGTGTGCCACGGATTCGAGCGATTTTAGAAGGGATGGAGC
AGCCTGCTCTAGCCTATCTCATCGCACAGCTGGATGCCATTCCGGAGTTGGAGAGCTTGATTAGTGCTGCCATTGCTCCT
GAAGCTCCTCACGTGATTACGGAAGGTGGCATTATCCGTACGGGATTTGATGAGACCTTAGACAAGTACCGTCGTGTGCT
CAGAGAAGGGACTAGCTGGATTGCTGAGATTGAGGCTAAGGAGAGAGAAAACTCTGGCATCAGTACGCTCAAGATCGACT
ACAATAAAAAAGATGGTTACTATTTCCATGTGACTAATTCGCAACTGGGAAATGTTCCAGCCCACTTTTTCCGCAAGGCA
ACACTGAAAAACTCGGAACGCTTTGGGACAGAGGAGTTAGCCCGTATCGAGGGAGATATGCTGGAGGCGCGTGAGAAGTC
AGCCAACCTAGAATATGAAATCTTTATGCGTATCCGTGAGGAAGTCAGCAAGTACATCCAGCGTTTGCAGGCTTTAGCAC
AAGGAATTGCGACGATTGATGTTTTGCAAAGTCTGGCGGTTGTAGCTGAAACCCAGCATTTGATTCGACCTGAGTTTGGA
GAAGATTCACAAATAGATATCCAAAAAGGGCGCCATGCTGTCGTCGAAAAGGTCATGGGAGCTCAGACCTATATTCCTAA
TACTATTCAGATGGCAGAAGATACGAGTATTCAGCTAATCACAGGGCCCAACATGAGTGGGAAGTCTACCTACATGCGCC
AGTTAGCTATGACGGCGGTTATGGCCCAGCTAGGCTCGTATGTGCCGGCAGAAAGCGCCCATTTGCCTATCTTCGATGCT
ATCTTTACCCGTATCGGAGCAGCAGATGACTTGGTTTCAGGTCAATCAACCTTTATGGTGGAGATGATGGAGGCTAACAA
TGCCATTTCTCATGCGACCAAGGATTCCTTGATTCTCTTTGATGAATTGGGACGAGGAACTGCAACATATGACGGAATGG
CTCTTGCTCAGTCCATCATCGAATACATCCATGAACATATCGGAGCCAAAACCCTCTTTGCGACCCACTACCATGAGTTG
ACCAGTCTGGAGTCCAGCTTGAAAAACTTGGTCAATGTCCATGTGGCGACCTTGGAGCAGGATGGGCAGGTGACCTTCCT
TCATAAGATCGAACCAGGACCAGCTGACAAATCCTACGGTATCCATGTTGCTAAGATTGCTGGCTTACCAGCAGAACTTT
TAGCAAGGGCGGATAAGATATTGACTCAACTGGAGAATCAAGGGACGGAAAGTCCTGCTCCAATGAGAGAAACAAGTGCT
GTTACTGAACAGATGTCACTCTTTGACGCGCCTGCAGAGCATCCTATCCTAGCAGAATTAGCTAAACTGGATGTGTACAA
TATGACACCGATGCAGGCTATGAACGTCTTGGCCGAGCTCAAACAAAAGTTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	95.972	100	0.96
mutS	Pseudomonas stutzeri strain ATCC 17587	37.063	100	0.377