Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   I6H77_RS04850 Genome accession   NZ_CP066021
Coordinates   996891..998840 (+) Length   649 a.a.
NCBI ID   WP_000018214.1    Uniprot ID   -
Organism   Streptococcus oralis strain FDAARGOS_1020     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 991891..1003840
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H77_RS04830 (I6H77_04830) argR 992713..993159 (+) 447 WP_001231483.1 arginine repressor -
  I6H77_RS04835 (I6H77_04835) hexA 993210..995744 (+) 2535 WP_000179917.1 DNA mismatch repair protein MutS Machinery gene
  I6H77_RS04840 (I6H77_04840) - 995787..996245 (-) 459 WP_000743977.1 DUF3021 domain-containing protein -
  I6H77_RS04845 (I6H77_04845) - 996242..996682 (-) 441 WP_000861947.1 LytTR family DNA-binding domain-containing protein -
  I6H77_RS04850 (I6H77_04850) hexB 996891..998840 (+) 1950 WP_000018214.1 DNA mismatch repair endonuclease MutL Machinery gene
  I6H77_RS04855 (I6H77_04855) - 998993..999490 (-) 498 WP_000761362.1 helix-turn-helix domain-containing protein -
  I6H77_RS04860 (I6H77_04860) ruvA 999649..1000242 (+) 594 WP_000273401.1 Holliday junction branch migration protein RuvA Machinery gene
  I6H77_RS04865 (I6H77_04865) - 1000252..1000812 (+) 561 WP_001126059.1 DNA-3-methyladenine glycosylase I -
  I6H77_RS04870 (I6H77_04870) - 1000813..1001487 (+) 675 WP_000987418.1 CPBP family intramembrane glutamic endopeptidase -
  I6H77_RS04875 (I6H77_04875) - 1001559..1001822 (-) 264 WP_000166112.1 SemiSWEET family transporter -
  I6H77_RS04880 (I6H77_04880) - 1001896..1002930 (-) 1035 WP_025169048.1 S66 family peptidase -
  I6H77_RS04885 (I6H77_04885) - 1003251..1003598 (-) 348 WP_000331830.1 TfoX/Sxy family protein -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73296.71 Da        Isoelectric Point: 5.5332

>NTDB_id=453002 I6H77_RS04850 WP_000018214.1 996891..998840(+) (hexB) [Streptococcus oralis strain FDAARGOS_1020]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDAGSSQITIEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEKVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLASAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKERELMALLSE
AISNSLKEQALIPDALENLAKSTVRNRQKVEQTILPLKENTLYYEKTEVTRASQAEVADHQVELTEEGQDLTLFAKETLE
QLTKPAKLHFAERKPANYDQLDHPELDLASLDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMALLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=453002 I6H77_RS04850 WP_000018214.1 996891..998840(+) (hexB) [Streptococcus oralis strain FDAARGOS_1020]
ATGTCTCATATTATTGAATTGCCAGAGGTGCTGGCAAACCAGATCGCAGCAGGAGAGGTCATTGAACGTCCTGCTAGCGT
GGTCAAAGAGTTGGTAGAAAATGCTATTGACGCGGGCTCTAGCCAGATTACCATTGAGATTGAGGAAGCTGGTCTTAAGA
AGATTCAAATCACTGATAATGGTCATGGAATTGCCCACGATGAGGTGGAATTGGCCCTGCGTCGTCATGCGACCAGTAAG
ATAAAAAATCAAGCAGACCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCCTGCCCTCTATCGCTTCTGTCAG
CGTCTTGACTCTGTTGACGGCGGTAGATGGTGCGAGTCATGGAACCAAGCTCGTTGCGCGTGGAGGTGAGGTTGAGAAAG
TCATACCAGCGACTAGTCCTGTGGGGACCAAAGTTTGTGTGGAGGACCTCTTTTTCAACACACCAGCTCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGCTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCAGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAACTGCGTCAAGCCATCGCAGGGATTTATG
GTTTGGCGAGTGCCAAGAAGATGATTGAAATTGAGAATTCTGACTTAGATTTCGAAATTTCAGGTTTTGTGTCTTTACCT
GAATTAACCCGAGCAAATCGTAACTATATCAGCCTCTTCATCAATGGCCGTTATATCAAGAACTTCTTGCTCAACCGTGC
TATTTTGGATGGTTACGGAAGCAAGCTTATGGTAGGGCGTTTTCCACTGGCTGTCATTCACATCCATATTGACCCCTATC
TAGCTGATGTCAATGTGCATCCAACCAAACAAGAAGTGCGGATTTCTAAGGAAAGAGAACTGATGGCGCTGCTTTCAGAA
GCTATTTCAAATAGTCTCAAGGAACAAGCCTTGATTCCTGATGCTTTAGAAAATCTTGCCAAGTCGACCGTGCGCAATCG
TCAAAAGGTAGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTTTACTATGAAAAAACGGAGGTAACTAGAGCCAGTC
AAGCTGAGGTGGCTGATCATCAGGTTGAATTAACTGAGGAAGGGCAGGATTTAACCTTGTTTGCCAAGGAAACCTTGGAG
CAACTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTATGACCAATTAGACCATCCAGAGTTAGA
CTTAGCCAGTCTTGATAAGGCTTATGACAAGCTGGAGAGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AGATGCACGGGACCTATCTCTTTGCCCAGGGGCGAGATGGACTCTACATCATAGACCAGCACGCGGCTCAGGAACGAGTC
AAGTACGAGGAATACCGTGAAAGCATCGGCAATGTTGACCAGAGTCAGCAACAACTCCTAGTGCCCTACATCTTTGAATT
TCCTGCGGATGATGCTCTTCGTCTCAAGGAAAGAATGGCACTTTTAGAGGAAGTAGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATCCTGCGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAGTCAGGTATCTATGAAATGTGCGAC
ATGCTGCTCTTGACTAAGGAAGTTTCTATCAAAAAATACCGAGCAGAGCTAGCCATCATGATGTCCTGCAAGCGGTCTAT
CAAGGCCAACCATCGTATCGATGACCATTCAGCTCGACAGCTCCTTTATCAGCTTTCTCAATGTGACAATCCATATAACT
GTCCCCATGGACGTCCTGTTTTGGTGCATTTTACCAAGTCAGACATGGAAAAGATGTTCCGACGCATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-110)

MutL C terminal dimerisation domain (MutL_C)

(450-592)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

96.61

100

0.966