Detailed information NTG0451300

Bioinformatically predicted

Overview

• Name: codY
• Type: Regulator
• Locus tag: STRR_RS07650
• Genome accession: NZ_CP065788
• Coordinates: 1479273..1480058 (-)
• Length: 261 a.a.
• NCBI ID: WP_002951720.1
• Uniprot ID: Q5M305
• Organism: Streptococcus thermophilus strain RR
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1474273..1485058

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STRR_RS07615 (STRR_07575)	gatC	1474335..1474637 (-)	303	WP_002884769.1	Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC	-
STRR_RS07620 (STRR_07580)	-	1474777..1475031 (-)	255	WP_024010053.1	glycosyl transferase	-
STRR_RS07625 (STRR_07585)	-	1475044..1475253 (-)	210	WP_080998437.1	glycosyltransferase	-
STRR_RS07630 (STRR_07590)	-	1475569..1477013 (-)	1445	Protein_1462	6-phospho-beta-glucosidase	-
STRR_RS07635 (STRR_07595)	msrA	1477166..1477675 (-)	510	WP_041827375.1	peptide-methionine (S)-S-oxide reductase MsrA	-
STRR_RS07640 (STRR_07600)	-	1477687..1478535 (-)	849	WP_014608646.1	MetQ/NlpA family ABC transporter substrate-binding protein	-
STRR_RS07645 (STRR_07605)	-	1478659..1479210 (-)	552	WP_002946999.1	cysteine hydrolase family protein	-
STRR_RS07650 (STRR_07610)	codY	1479273..1480058 (-)	786	WP_002951720.1	GTP-sensing pleiotropic transcriptional regulator CodY	Regulator
STRR_RS07655 (STRR_07615)	-	1480318..1481532 (-)	1215	WP_002951721.1	pyridoxal phosphate-dependent aminotransferase	-
STRR_RS07660 (STRR_07620)	-	1481887..1482339 (+)	453	WP_002946987.1	universal stress protein	-
STRR_RS07665 (STRR_07625)	-	1482519..1483090 (+)	572	Protein_1469	IS30 family transposase	-
STRR_RS07670 (STRR_07630)	-	1483162..1483335 (-)	174	WP_011681546.1	hypothetical protein	-
STRR_RS07675 (STRR_07635)	-	1483396..1483770 (-)	375	WP_011681547.1	membrane protein	-
STRR_RS07680 (STRR_07640)	pflA	1483982..1484782 (-)	801	WP_071417327.1	pyruvate formate-lyase-activating protein	-

Sequence

Protein

• Length: 261 a.a.
• Molecular weight: 28919.13 Da
• Isoelectric Point: 4.5802

>NTDB_id=451300 STRR_RS07650 WP_002951720.1 1479273..1480058(-) (codY) [Streptococcus thermophilus strain RR]
MANLLDKTRKITSILQRSVDSLEGDLPYNNMAAQLADIIDCNAAIVNGGGALLGFAMKYKTNNDRVEKFFKAKQLPEEYI
RGISRVYDTQENIGIDSDLTIFPVELKDDFPDGLTTIAPIYGGGMRLGSFIIWRNDHDFVDDDLILVEIASTVVGLQLLH
LQTENLEETIRKQTAINMAINTLSYSEIKAVSAILNELDGLEGRLTASVIADRIGITRSVIVNALRKLESAGIIESRSLG
MKGTYLKVLNEGIYDKLKEYE

Nucleotide

• Length: 786 bp

>NTDB_id=451300 STRR_RS07650 WP_002951720.1 1479273..1480058(-) (codY) [Streptococcus thermophilus strain RR]
ATGGCAAATTTGCTTGATAAAACACGTAAAATTACTTCTATCTTGCAACGCTCAGTAGATAGTTTGGAAGGAGATCTTCC
ATACAACAACATGGCTGCTCAGTTGGCAGATATTATTGATTGTAATGCTGCTATTGTAAATGGTGGAGGTGCTCTCCTTG
GTTTTGCTATGAAATACAAAACCAACAATGACCGTGTGGAAAAGTTTTTTAAAGCTAAACAACTTCCAGAGGAATACATA
CGTGGTATCAGCCGTGTTTATGATACTCAAGAAAATATCGGTATTGACAGTGACTTGACCATCTTCCCAGTGGAATTAAA
AGATGATTTCCCTGACGGTTTGACTACAATTGCACCAATCTATGGTGGTGGTATGCGTCTTGGTTCTTTCATTATTTGGC
GTAACGACCATGATTTTGTGGACGACGACCTTATCTTGGTTGAGATTGCATCTACAGTAGTTGGTTTGCAATTGTTGCAT
CTTCAAACAGAAAACTTGGAAGAAACGATTCGTAAACAAACAGCTATTAATATGGCTATTAATACCTTGTCTTACTCAGA
AATCAAGGCAGTTTCAGCTATCTTGAATGAGTTGGACGGTTTAGAAGGTCGTTTGACAGCCTCTGTTATCGCGGACCGTA
TCGGAATTACTCGTTCTGTTATTGTTAATGCTCTTCGTAAATTAGAATCAGCTGGTATTATTGAAAGTCGTTCGCTTGGT
ATGAAAGGCACTTACCTTAAAGTCCTTAACGAAGGTATCTACGACAAATTGAAAGAATACGAATAA

Domains

Predicted by InterProScan.

• CodY GAF-like domain (CodY) (3-182)

• CodY helix-turn-helix domain (HTH_CodY) (201-261)

3D structure

• AlphaFold DB: Q5M305

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
codY	Lactococcus lactis subsp. lactis strain DGCC12653	64.591	98.467	0.636
codY	Bacillus subtilis subsp. subtilis str. 168	53.036	94.636	0.502