Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   HRE60_RS01635 Genome accession   NZ_CP054153
Coordinates   317739..319058 (+) Length   439 a.a.
NCBI ID   WP_181670937.1    Uniprot ID   A0A7L6WJI9
Organism   Streptococcus salivarius strain DB-B5     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 317739..329307 317739..319058 within 0


Gene organization within MGE regions


Location: 317739..329307
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HRE60_RS01635 (HRE60_01635) comFA/cflA 317739..319058 (+) 1320 WP_181670937.1 DEAD/DEAH box helicase Machinery gene
  HRE60_RS01640 (HRE60_01640) - 319039..319701 (+) 663 WP_181670938.1 ComF family protein -
  HRE60_RS01645 (HRE60_01645) raiA 319780..320328 (+) 549 WP_002883786.1 ribosome-associated translation inhibitor RaiA -
  HRE60_RS01700 (HRE60_01700) - 326251..327183 (+) 933 WP_181670939.1 manganese-dependent inorganic pyrophosphatase -
  HRE60_RS01705 (HRE60_01705) - 327238..327897 (+) 660 WP_181670940.1 DUF1803 domain-containing protein -
  HRE60_RS01710 (HRE60_01710) - 327927..328460 (-) 534 WP_002886644.1 DUF402 domain-containing protein -
  HRE60_RS01715 (HRE60_01715) recX 328531..329307 (-) 777 WP_181670941.1 recombination regulator RecX -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 50703.75 Da        Isoelectric Point: 9.0237

>NTDB_id=451153 HRE60_RS01635 WP_181670937.1 317739..319058(+) (comFA/cflA) [Streptococcus salivarius strain DB-B5]
MVPKEYYGRLFTKEQLPVDYHSEAFTLESMIKVDKQLRCKRCYSQIEEDWQLPEGQYYCRACIVFGRNQEGKELYYFPSK
TSEIEFPVLKWLGELTPYQAEVSEKLLETYQKQKDSLVHAVTGAGKTEMIYKIVAYVLESKGNVAIASPRVDVCRELFLR
MQRDFTCSISLLHAESEPYDGSPLVIATTHQLLKFYQNFDLVIVDEVDAFPFVGNVMLNHAVEQAKKETGRYIYLTATST
LSLEEQVRLGALEKRHLARRFHGNPLVLPKFCWQGRLQKSLMRGKLPRPLLYQIKKQRKSKFPLLIFFPNIAIGEKFTNI
LQKYLPDEKMAFVSSKSEERSATVEQFREKELSILVTTTILERGVTFPQVDVFVCMANHHLYTSSSLIQIGGRVGRSPDR
PTGKLYFFHEGLSKSMLRCREEIKVMNKKGGFNNEVSTM

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=451153 HRE60_RS01635 WP_181670937.1 317739..319058(+) (comFA/cflA) [Streptococcus salivarius strain DB-B5]
ATGGTACCTAAAGAATATTATGGACGACTATTTACGAAAGAACAGTTGCCAGTGGACTATCACTCAGAGGCTTTTACATT
AGAAAGCATGATAAAGGTCGATAAACAACTTAGATGTAAAAGATGTTACAGTCAGATAGAGGAAGATTGGCAATTACCGG
AAGGTCAGTATTATTGCAGAGCATGTATTGTCTTTGGCAGAAATCAAGAAGGAAAAGAACTCTATTATTTTCCTTCAAAA
ACATCTGAAATTGAATTTCCTGTTTTGAAGTGGTTGGGGGAACTGACTCCCTATCAAGCTGAGGTCTCAGAGAAGCTTTT
AGAAACATATCAAAAACAGAAAGACAGCCTCGTACATGCTGTGACTGGTGCTGGGAAGACCGAGATGATTTATAAAATCG
TTGCCTATGTTCTTGAAAGTAAAGGTAATGTAGCTATCGCAAGTCCTCGGGTTGATGTTTGTCGAGAGTTATTTCTTCGT
ATGCAGAGGGATTTTACTTGTAGTATTTCTCTGCTTCATGCTGAGAGTGAACCATATGATGGTAGTCCGCTTGTAATAGC
TACCACCCATCAACTACTAAAGTTTTACCAGAACTTTGACCTAGTTATCGTTGATGAGGTTGATGCATTCCCTTTTGTAG
GAAATGTCATGTTAAATCATGCTGTGGAGCAGGCAAAGAAGGAAACCGGTCGCTATATTTATTTAACAGCGACTTCTACA
TTATCTTTAGAGGAGCAAGTGCGACTTGGAGCTTTAGAAAAGCGTCACCTTGCCAGACGTTTCCATGGAAATCCTTTAGT
ACTTCCTAAATTCTGCTGGCAGGGAAGATTACAAAAATCTCTAATGAGAGGCAAGCTTCCAAGGCCTCTTCTTTATCAGA
TTAAAAAGCAACGTAAATCAAAGTTTCCTCTATTAATCTTTTTCCCAAATATAGCGATAGGTGAAAAGTTTACCAATATT
CTACAAAAATATCTTCCAGATGAAAAAATGGCCTTTGTTTCTTCAAAAAGCGAGGAGCGCTCAGCTACCGTAGAGCAGTT
CCGGGAAAAAGAGTTATCCATCTTAGTGACAACAACTATCCTTGAACGTGGTGTAACCTTTCCACAAGTAGATGTTTTTG
TTTGTATGGCAAATCATCACTTATACACTAGTTCGAGTCTTATTCAGATAGGAGGTCGAGTTGGAAGATCTCCAGATAGA
CCGACAGGAAAGCTTTATTTCTTTCATGAAGGACTATCCAAATCAATGCTTCGTTGTCGAGAAGAAATAAAAGTTATGAA
TAAAAAAGGAGGATTTAACAATGAAGTGTCTACTATGTAA

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(290-396)

Type III restriction enzyme, res subunit (ResIII)

(94-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7L6WJI9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae TIGR4

56.381

98.178

0.554
  comFA/cflA Streptococcus pneumoniae Rx1

56.381

98.178

0.554
  comFA/cflA Streptococcus pneumoniae D39

56.381

98.178

0.554
  comFA/cflA Streptococcus pneumoniae R6

56.381

98.178

0.554
  comFA/cflA Streptococcus mitis NCTC 12261

55.53

98.861

0.549
  comFA/cflA Streptococcus mitis SK321

54.988

98.178

0.54
  comFA Lactococcus lactis subsp. cremoris KW2

45.476

95.672

0.435
  comFA Latilactobacillus sakei subsp. sakei 23K

38.073

99.317

0.378