Detailed information    

insolico Bioinformatically predicted

Overview

Name   eeP   Type   Regulator
Locus tag   HQ618_RS09385 Genome accession   NZ_CP053890
Coordinates   1854290..1855549 (-) Length   419 a.a.
NCBI ID   WP_000900650.1    Uniprot ID   A0A0E1EP49
Organism   Streptococcus agalactiae strain GBS68     
Function   processing of ComS (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1843467..1912592 1854290..1855549 within 0


Gene organization within MGE regions


Location: 1843467..1912592
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HQ618_RS09350 (HQ618_09310) - 1844105..1845112 (+) 1008 WP_000034938.1 sugar kinase -
  HQ618_RS09355 (HQ618_09315) - 1845124..1845762 (+) 639 WP_000597407.1 bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase -
  HQ618_RS09360 (HQ618_09320) - 1845809..1846423 (-) 615 WP_000008878.1 nitroreductase family protein -
  HQ618_RS09365 (HQ618_09325) - 1846556..1846981 (-) 426 WP_000526288.1 MarR family winged helix-turn-helix transcriptional regulator -
  HQ618_RS09370 (HQ618_09330) - 1847107..1851513 (-) 4407 WP_001292143.1 PolC-type DNA polymerase III -
  HQ618_RS09375 (HQ618_09335) - 1851636..1852220 (-) 585 WP_000842267.1 glycoside hydrolase family 73 protein -
  HQ618_RS09380 (HQ618_09340) - 1852345..1854198 (-) 1854 WP_000814042.1 proline--tRNA ligase -
  HQ618_RS09385 (HQ618_09345) eeP 1854290..1855549 (-) 1260 WP_000900650.1 RIP metalloprotease RseP Regulator
  HQ618_RS09390 (HQ618_09350) - 1855580..1856374 (-) 795 WP_000664688.1 phosphatidate cytidylyltransferase -
  HQ618_RS09395 (HQ618_09355) - 1856389..1857141 (-) 753 WP_000469560.1 isoprenyl transferase -
  HQ618_RS09400 (HQ618_09360) yajC 1857308..1857649 (-) 342 WP_000056607.1 preprotein translocase subunit YajC -
  HQ618_RS09405 (HQ618_09365) - 1857726..1858070 (-) 345 WP_000286792.1 thioredoxin domain-containing protein -
  HQ618_RS09410 (HQ618_09370) - 1858261..1859424 (-) 1164 WP_001293705.1 NADP-dependent malic enzyme -
  HQ618_RS09415 (HQ618_09375) - 1859449..1860786 (-) 1338 WP_000786046.1 2-hydroxycarboxylate transporter family protein -
  HQ618_RS09420 (HQ618_09380) - 1860990..1862465 (+) 1476 WP_041971581.1 cache domain-containing protein -
  HQ618_RS09425 (HQ618_09385) - 1862467..1863147 (+) 681 WP_000382776.1 response regulator -
  HQ618_RS09430 (HQ618_09390) galE 1863168..1864163 (-) 996 WP_000279626.1 UDP-glucose 4-epimerase GalE -
  HQ618_RS09435 (HQ618_09395) - 1864251..1865858 (-) 1608 WP_235096280.1 alpha-glucosidase -
  HQ618_RS09440 (HQ618_09400) - 1865987..1867120 (-) 1134 WP_000229966.1 ABC transporter ATP-binding protein -
  HQ618_RS09445 (HQ618_09405) - 1867221..1868072 (-) 852 WP_000345941.1 helix-turn-helix domain-containing protein -
  HQ618_RS09450 (HQ618_09410) - 1868167..1869063 (-) 897 WP_001018634.1 aldose 1-epimerase family protein -
  HQ618_RS09455 (HQ618_09415) lacD 1869117..1870094 (-) 978 WP_000524687.1 tagatose-bisphosphate aldolase -
  HQ618_RS09460 (HQ618_09420) - 1870096..1871028 (-) 933 WP_000604244.1 tagatose-6-phosphate kinase -
  HQ618_RS09465 (HQ618_09425) lacB 1871039..1871554 (-) 516 WP_000686152.1 galactose-6-phosphate isomerase subunit LacB -
  HQ618_RS09470 (HQ618_09430) lacA 1871575..1872000 (-) 426 WP_000152527.1 galactose-6-phosphate isomerase subunit LacA -
  HQ618_RS09475 (HQ618_09435) - 1872247..1874697 (-) 2451 WP_000176328.1 exo-alpha-sialidase -
  HQ618_RS09480 (HQ618_09440) - 1874938..1876386 (-) 1449 WP_001195839.1 PTS galactitol transporter subunit IIC -
  HQ618_RS09485 (HQ618_09445) - 1876426..1876731 (-) 306 WP_000590543.1 PTS sugar transporter subunit IIB -
  HQ618_RS09490 (HQ618_09450) - 1876733..1877206 (-) 474 WP_000458428.1 PTS sugar transporter subunit IIA -
  HQ618_RS09495 (HQ618_09455) - 1877415..1878191 (+) 777 WP_000919190.1 DeoR/GlpR family DNA-binding transcription regulator -
  HQ618_RS09500 (HQ618_09460) - 1878473..1881010 (-) 2538 WP_235065591.1 pneumococcal-type histidine triad protein -
  HQ618_RS09505 (HQ618_09465) - 1881037..1881960 (-) 924 WP_000822451.1 metal ABC transporter solute-binding protein, Zn/Mn family -
  HQ618_RS09510 (HQ618_09470) dtd 1882215..1882658 (-) 444 WP_000691434.1 D-aminoacyl-tRNA deacylase -
  HQ618_RS09515 (HQ618_09475) - 1882668..1884884 (-) 2217 WP_000237875.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
  HQ618_RS09520 (HQ618_09480) - 1885115..1886332 (-) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  HQ618_RS09525 (HQ618_09485) - 1886414..1886617 (-) 204 WP_000814511.1 excisionase -
  HQ618_RS09530 - 1886601..1886852 (+) 252 WP_001845478.1 hypothetical protein -
  HQ618_RS09535 (HQ618_09490) - 1887078..1887308 (-) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  HQ618_RS09540 (HQ618_09495) - 1887305..1887727 (-) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  HQ618_RS09545 (HQ618_09500) - 1888232..1888585 (+) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  HQ618_RS09550 (HQ618_09505) - 1888645..1888812 (-) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  HQ618_RS09555 (HQ618_09510) tet(M) 1888931..1890850 (-) 1920 WP_000691736.1 tetracycline resistance ribosomal protection protein Tet(M) -
  HQ618_RS10835 - 1890866..1890913 (-) 48 Protein_1812 hypothetical protein -
  HQ618_RS09565 (HQ618_09520) - 1891227..1892159 (-) 933 WP_001224318.1 conjugal transfer protein -
  HQ618_RS09570 (HQ618_09525) - 1892156..1893157 (-) 1002 WP_000769868.1 lysozyme family protein -
  HQ618_RS09575 (HQ618_09530) - 1893154..1895331 (-) 2178 WP_000804748.1 CD3337/EF1877 family mobilome membrane protein -
  HQ618_RS09580 (HQ618_09535) - 1895334..1897781 (-) 2448 WP_000331160.1 ATP-binding protein -
  HQ618_RS09585 (HQ618_09540) - 1897765..1898157 (-) 393 WP_000723888.1 conjugal transfer protein -
  HQ618_RS09590 (HQ618_09545) - 1898246..1898743 (-) 498 WP_000342539.1 antirestriction protein ArdA -
  HQ618_RS09595 (HQ618_09550) - 1898860..1899081 (-) 222 WP_001009056.1 hypothetical protein -
  HQ618_RS09600 (HQ618_09555) mobT 1899124..1900329 (-) 1206 WP_000398284.1 MobT family relaxase -
  HQ618_RS09605 (HQ618_09560) - 1900352..1900504 (-) 153 WP_000879507.1 hypothetical protein -
  HQ618_RS09610 (HQ618_09565) - 1900507..1901892 (-) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  HQ618_RS09615 (HQ618_09570) - 1901921..1902307 (-) 387 WP_000985015.1 YdcP family protein -
  HQ618_RS09620 (HQ618_09575) - 1902323..1902637 (-) 315 WP_000420682.1 YdcP family protein -
  HQ618_RS09625 (HQ618_09580) - 1903182..1905584 (+) 2403 WP_000033919.1 bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase -
  HQ618_RS09630 (HQ618_09585) nrdI 1905741..1906196 (+) 456 WP_001125401.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  HQ618_RS09635 (HQ618_09590) - 1906207..1907244 (+) 1038 WP_000450427.1 M42 family metallopeptidase -
  HQ618_RS09640 (HQ618_09595) - 1907244..1907741 (+) 498 WP_000226643.1 kinase -
  HQ618_RS09645 (HQ618_09600) - 1907963..1909000 (-) 1038 WP_000660653.1 extracellular solute-binding protein -
  HQ618_RS09650 (HQ618_09605) - 1909012..1909785 (-) 774 WP_000286068.1 response regulator -
  HQ618_RS09655 (HQ618_09610) - 1909789..1911438 (-) 1650 WP_001215138.1 sensor histidine kinase -
  HQ618_RS09660 (HQ618_09615) - 1911576..1912403 (-) 828 WP_000841957.1 PTS system mannose/fructose/sorbose family transporter subunit IID -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 46114.17 Da        Isoelectric Point: 10.0874

>NTDB_id=448714 HQ618_RS09385 WP_000900650.1 1854290..1855549(-) (eeP) [Streptococcus agalactiae strain GBS68]
MLGILTFIIIFGVIVVVHEFGHFYFAKKSGILVREFAIGMGPKIFSHIDKEGTTYTIRILPLGGYVRMAGWGDDKTEIKT
GTPASLTLNKEGIVTRINLSGKQLDNTSLPINVTAYDLEDKLTITGLVLSETKTYSVDHDATIIEEDGTEIRIAPLDVQY
QNASVWGRLITNFAGPMNNFILGLVVFIALAFIQGGVQDLSTNQVRVSENGPAASAGLKNNDRILQIGSHKVSNWEQLTA
AVEKSTRHLEKKQKLALKIKSKEVVKTINVKPQKVDKSYIIGIMPALKTSFKDKLLGGFKLAWESFFRILNELKKLIAHF
SINKLGGPVALYQASSQAAKNGFVTVLNLMGLISINLGIMNLIPIPALDGGKIVMNILEAIRRKPLKQETETYITLAGVA
VMLVLMIAVTWNDIMRAFF

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=448714 HQ618_RS09385 WP_000900650.1 1854290..1855549(-) (eeP) [Streptococcus agalactiae strain GBS68]
ATGCTAGGAATTTTAACCTTTATTATTATTTTTGGTGTCATTGTAGTTGTTCACGAATTTGGGCATTTCTATTTTGCAAA
GAAATCAGGAATTCTTGTTCGTGAATTTGCTATTGGTATGGGTCCAAAAATCTTTTCTCACATTGATAAAGAAGGAACAA
CCTATACTATTCGTATATTACCGCTAGGTGGTTATGTCCGTATGGCTGGTTGGGGTGATGATAAGACTGAAATTAAGACA
GGGACGCCGGCTAGCCTTACTTTAAATAAAGAAGGCATTGTAACTCGTATTAATTTATCAGGAAAACAATTAGACAATAC
TTCTTTACCAATCAATGTCACAGCTTATGATCTAGAAGATAAACTAACTATCACAGGATTGGTCTTAAGTGAGACAAAAA
CCTATAGTGTTGATCACGATGCTACTATCATTGAGGAGGATGGTACTGAAATTCGTATTGCTCCCTTAGATGTGCAGTAT
CAGAATGCTTCTGTATGGGGGCGCTTAATTACCAATTTTGCAGGTCCGATGAATAATTTTATTTTAGGTCTTGTAGTCTT
TATTGCACTTGCTTTTATTCAAGGAGGTGTTCAAGATTTATCAACCAATCAGGTCCGTGTATCAGAAAATGGTCCTGCTG
CTAGTGCAGGTTTAAAAAATAATGATCGTATTTTACAAATAGGGTCGCACAAAGTTTCTAACTGGGAACAGTTGACAGCA
GCAGTAGAAAAGTCAACTAGGCATTTAGAAAAAAAACAAAAACTTGCCCTTAAGATTAAGAGCAAAGAGGTGGTGAAAAC
GATCAACGTTAAGCCACAGAAAGTTGATAAATCCTACATCATCGGCATTATGCCAGCTCTAAAGACAAGCTTTAAAGACA
AACTTTTAGGTGGATTTAAACTAGCATGGGAAAGTTTCTTTAGAATTTTAAATGAATTAAAGAAACTTATTGCTCATTTT
AGTATTAATAAATTGGGAGGTCCAGTAGCTCTCTATCAGGCTAGTAGCCAAGCTGCTAAAAATGGTTTCGTCACAGTTCT
CAACTTAATGGGATTAATCTCTATCAACTTAGGTATTATGAATCTCATCCCTATACCAGCCCTTGACGGGGGTAAGATAG
TGATGAATATTTTAGAAGCCATTCGTCGCAAACCACTTAAACAAGAAACAGAAACTTATATTACGCTCGCTGGGGTAGCA
GTTATGTTAGTATTAATGATTGCTGTAACCTGGAACGATATCATGCGAGCTTTCTTCTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(6-405)

PDZ domain (PDZ_2)

(205-271)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E1EP49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  eeP Streptococcus thermophilus LMG 18311

69.524

100

0.697
  eeP Streptococcus thermophilus LMD-9

69.286

100

0.695