Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   STR1_RS06240 Genome accession   NZ_CP065486
Coordinates   1206236..1208023 (-) Length   595 a.a.
NCBI ID   WP_011681323.1    Uniprot ID   Q03K10
Organism   Streptococcus thermophilus strain R1     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1201236..1213023
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STR1_RS06220 (STR1_06275) - 1202199..1202869 (-) 671 Protein_1183 DNA alkylation repair protein -
  STR1_RS06225 (STR1_06280) - 1203031..1203543 (-) 513 WP_011681320.1 GNAT family N-acetyltransferase -
  STR1_RS06230 (STR1_06285) - 1203703..1204504 (+) 802 Protein_1185 ISL3 family transposase -
  STR1_RS06235 (STR1_06290) cls 1204597..1206147 (-) 1551 WP_198362551.1 cardiolipin synthase -
  STR1_RS06240 (STR1_06295) uvrC 1206236..1208023 (-) 1788 WP_011681323.1 excinuclease ABC subunit UvrC Machinery gene
  STR1_RS06245 (STR1_06300) - 1208083..1208778 (-) 696 WP_011681324.1 YjjG family noncanonical pyrimidine nucleotidase -
  STR1_RS06250 (STR1_06305) sdaAB 1209056..1209727 (+) 672 WP_011681325.1 L-serine ammonia-lyase, iron-sulfur-dependent subunit beta -
  STR1_RS06255 (STR1_06310) sdaAA 1209740..1210609 (+) 870 WP_011226205.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -
  STR1_RS06260 - 1210793..1211025 (+) 233 Protein_1191 IS30 family transposase -
  STR1_RS06265 (STR1_06315) - 1211332..1211901 (-) 570 WP_014727594.1 hypothetical protein -
  STR1_RS06270 (STR1_06320) - 1212044..1212828 (-) 785 Protein_1193 ABC transporter permease -

Sequence

Protein


Download         Length: 595 a.a.        Molecular weight: 68470.97 Da        Isoelectric Point: 9.6924

>NTDB_id=448329 STR1_RS06240 WP_011681323.1 1206236..1208023(-) (uvrC) [Streptococcus thermophilus strain R1]
MNGLIKHKLELLPSNPGCYLHKDKFGNIIYVGKAKNLKNRVRSYFRGSHDTKTELLVSEIADFEFIVTESNIEALLLEIN
LIQENMPKFNIRLKDGKSYPFIKITKELYPRLLITRQVKKDGGLYFGPYPDSGAANEIKKLLDRIFPFKKCKNPANKVCF
YYHIGQCNAHTICHTTEDYWQGLVEDVKNFLNGHDDKIVNQLKAKMKDMSDQMAFERAAEYRDLIEAVSTLRTKQRVIRQ
DMQDRDIFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYMGQFYLDSRHLKPKEIFIPGDIDQESVEAL
VGDEVKVFKPKRGEKKQLVNLATKNARVSLTQKFDLLEKDIAKTQGAIENLGKLMGIPTPVRIESFDNSNIMGTSPVSAM
VVFENGKPNKKEYRKYKIKTVEGPDDYASMREVIRRRYSRVKRDGLTPPDLIIMDGGQGQVNVAKDVLRNELNLSIPVAG
LQKNDKHQTNELLFGDPLRVIDLPRQSEEFFLLHRIQDEVHRFAITFHRQVRSKNSFSSKLDGVEGLGPKRKQKLLKNFK
SMTAIQQASVEDIQALGIPKKVAQALLDKLSQDSH

Nucleotide


Download         Length: 1788 bp        

>NTDB_id=448329 STR1_RS06240 WP_011681323.1 1206236..1208023(-) (uvrC) [Streptococcus thermophilus strain R1]
ATGAATGGTCTGATTAAACATAAGTTGGAACTGCTCCCAAGCAACCCAGGGTGTTATCTCCACAAGGACAAATTCGGCAA
TATTATTTATGTCGGTAAGGCTAAAAATCTAAAAAATCGTGTGCGTAGCTATTTTCGTGGAAGCCATGATACCAAGACGG
AGCTTTTGGTATCTGAGATTGCAGACTTTGAATTTATCGTAACCGAGTCTAATATCGAGGCCCTGCTTTTGGAAATTAAC
CTCATTCAAGAGAATATGCCCAAATTTAACATTCGCCTCAAGGATGGCAAGTCTTATCCATTTATCAAGATTACTAAGGA
ACTCTATCCAAGGCTCTTGATTACCCGCCAGGTTAAGAAGGATGGTGGTCTCTATTTTGGTCCTTACCCAGACTCTGGTG
CAGCCAATGAAATCAAGAAGCTGTTGGACCGTATTTTCCCCTTTAAGAAATGTAAAAATCCTGCTAACAAGGTCTGTTTC
TATTACCATATTGGCCAATGTAATGCCCACACCATCTGTCACACCACTGAGGACTATTGGCAAGGTTTGGTTGAGGATGT
CAAGAATTTTCTAAACGGTCATGATGATAAAATCGTTAACCAGCTTAAGGCCAAGATGAAGGACATGTCTGATCAGATGG
CGTTTGAGCGGGCAGCAGAATATCGAGATCTGATTGAGGCAGTGTCGACGCTCAGGACCAAACAAAGGGTTATCCGTCAA
GATATGCAGGACCGCGATATTTTTGGCTACTACGTGGACAAGGGCTGGATGTGTGTTCAAGTTTTCTTTGTTCGCCAAGG
AAAACTCATCCAGCGTGATGTCAATATGTTCCCTTACTATAATGATGCTGAGGAAGATTTTCTAACCTATATGGGTCAAT
TTTACTTGGATAGCCGTCATCTCAAGCCTAAGGAGATTTTCATTCCAGGGGACATTGATCAAGAGTCTGTCGAAGCTCTG
GTCGGAGATGAAGTCAAGGTTTTTAAACCGAAAAGAGGCGAGAAAAAGCAGTTGGTTAATCTGGCAACGAAAAATGCCCG
TGTCAGCCTGACTCAAAAATTTGATCTTCTTGAAAAAGATATAGCCAAGACCCAAGGAGCCATTGAAAATCTAGGCAAAC
TCATGGGAATTCCGACACCGGTTCGCATCGAGTCCTTCGATAACTCTAACATCATGGGAACGAGCCCTGTATCTGCCATG
GTCGTTTTTGAGAACGGCAAACCTAATAAAAAAGAGTACCGCAAATACAAGATTAAGACGGTTGAAGGTCCTGACGATTA
TGCCAGCATGCGTGAGGTCATTCGTCGCCGTTATAGTCGTGTCAAACGTGATGGTCTAACCCCACCAGACCTCATTATCA
TGGATGGTGGTCAAGGTCAGGTCAATGTCGCTAAGGACGTGCTTCGTAATGAGCTGAATCTATCTATCCCGGTTGCAGGT
CTTCAGAAAAATGACAAGCACCAAACCAATGAATTGCTCTTTGGAGATCCTTTGCGAGTCATTGATTTGCCACGTCAATC
CGAGGAGTTTTTCCTCCTTCACCGTATTCAGGATGAAGTACACCGCTTTGCCATCACCTTCCATCGACAAGTCCGTAGTA
AGAATAGTTTCAGTTCCAAACTTGATGGCGTGGAGGGGTTGGGACCTAAACGCAAACAAAAACTCCTCAAAAACTTCAAA
TCAATGACAGCTATCCAACAAGCCAGTGTCGAAGACATCCAAGCTCTTGGAATTCCTAAAAAAGTAGCTCAAGCTTTATT
AGATAAGTTGAGCCAAGATAGTCATTAA

Domains

Predicted by InterProScan.

GIY-YIG catalytic domain (GIY-YIG)

(16-87)

UvrB/uvrC motif (UVR)

(196-229)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(375-525)

Helix-hairpin-helix domain (HHH_5)

(540-590)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q03K10

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

75.804

99.328

0.753
  uvrC Streptococcus pneumoniae R6

75.465

99.328

0.75
  uvrC Streptococcus pneumoniae D39

75.465

99.328

0.75