Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   ST4052_RS05915 Genome accession   NZ_CP065476
Coordinates   1135442..1137229 (-) Length   595 a.a.
NCBI ID   WP_011227336.1    Uniprot ID   Q5LZ62
Organism   Streptococcus thermophilus strain 4052     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1130442..1142229
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST4052_RS05895 (ST4052_05965) - 1131405..1132046 (-) 642 Protein_1106 DNA alkylation repair protein -
  ST4052_RS05900 (ST4052_05970) - 1132239..1132751 (-) 513 WP_041828270.1 GNAT family N-acetyltransferase -
  ST4052_RS05905 (ST4052_05975) - 1132910..1133764 (+) 855 Protein_1108 transposase -
  ST4052_RS05910 (ST4052_05980) cls 1133803..1135353 (-) 1551 WP_179970536.1 cardiolipin synthase -
  ST4052_RS05915 (ST4052_05985) uvrC 1135442..1137229 (-) 1788 WP_011227336.1 excinuclease ABC subunit UvrC Machinery gene
  ST4052_RS05920 (ST4052_05990) - 1137289..1137984 (-) 696 WP_011227337.1 YjjG family noncanonical pyrimidine nucleotidase -
  ST4052_RS05925 (ST4052_05995) - 1138312..1138746 (+) 435 WP_011227338.1 biotin transporter BioY -
  ST4052_RS05930 (ST4052_06000) - 1138981..1139607 (-) 627 WP_002948550.1 ABC transporter permease -
  ST4052_RS05935 (ST4052_06005) - 1139612..1140367 (-) 756 WP_002948547.1 ABC transporter ATP-binding protein -
  ST4052_RS05940 (ST4052_06010) - 1140379..1141296 (-) 918 WP_002948546.1 glycine betaine ABC transporter substrate-binding protein -
  ST4052_RS05945 (ST4052_06015) - 1141293..1141937 (-) 645 WP_224103473.1 ABC transporter permease -

Sequence

Protein


Download         Length: 595 a.a.        Molecular weight: 68523.97 Da        Isoelectric Point: 9.5291

>NTDB_id=447285 ST4052_RS05915 WP_011227336.1 1135442..1137229(-) (uvrC) [Streptococcus thermophilus strain 4052]
MNDLIKHKLELLPSNPGCYLHKDKFGNIIYVGKAKNLKNRVRSYFRGSHDTKTELLVSEIADFEFIVTESNIEALLLEIN
LIQENMPKFNIRLKDGKSYPFIKITKELYPRLLITRQVKKDGGLYFGPYPDAGAANEIKKLLDRIFPFKKCKNPANKVCF
YYHIGQCKAHTICHTTEAYWQGLVEDVKNFLNGHDDKIVNQLKAKMKDMSDQMEFERAAEYRDLIEAVSTLRTKQRVIRQ
DMQDRDIFGYYVDKGWMCVQVFFVRQGKLIQRDVNMFPYYNDAEEDFLTYMGQFYLDSRHLKPKEIFIPGDIDQESVEAL
VGDEVKVFKPQRGEKKQLVNLATKNARVSLTQKFDLLEKDIAKTQGAIENLGKLMGIPTPVRIESFDNSNIMGTSPVSAM
VVFENGKPNKKEYRKYKIKTVEGPDDYASMREVIRRRYSRVKRDGLTPPDLIIIDGGQGQVNVAKDVLRNELNLSIPVAG
LQKNDKHQTNELLFGDPLRVIDLPRQSEEFFLLHRIQDEVHRFAITFHRQVRSKNSFSSKLDGVEGLGPKRKQKLLKNFK
SMTAIQQASVEDIQALGIPEKVAQALLDKLSQDSH

Nucleotide


Download         Length: 1788 bp        

>NTDB_id=447285 ST4052_RS05915 WP_011227336.1 1135442..1137229(-) (uvrC) [Streptococcus thermophilus strain 4052]
ATGAACGATCTGATTAAACATAAGTTGGAACTGCTCCCAAGCAACCCGGGGTGTTATCTCCACAAGGACAAATTTGGCAA
TATTATCTATGTCGGTAAGGCTAAAAATCTAAAAAATCGTGTGCGTAGCTATTTTCGTGGAAGTCATGATACCAAGACGG
AGCTTCTGGTATCCGAGATTGCAGACTTTGAATTTATCGTTACCGAGTCTAATATCGAGGCCTTGCTTTTGGAAATTAAC
CTCATCCAAGAGAATATGCCTAAATTTAACATTCGTCTCAAGGATGGCAAGTCTTATCCATTTATCAAGATTACTAAGGA
ACTCTATCCAAGGCTCTTGATTACCCGCCAGGTTAAGAAGGATGGTGGTCTTTATTTTGGTCCCTACCCAGATGCTGGTG
CAGCCAATGAAATCAAGAAGCTGTTGGACCGTATTTTCCCCTTTAAGAAATGTAAAAATCCTGCCAACAAGGTCTGTTTC
TACTACCATATTGGTCAATGTAAGGCTCACACCATCTGTCACACCACCGAAGCCTATTGGCAAGGTTTGGTTGAGGATGT
CAAGAATTTCCTAAACGGTCATGATGATAAAATCGTTAACCAGCTCAAGGCCAAGATGAAGGACATGTCTGATCAGATGG
AGTTTGAGCGGGCAGCAGAATATCGAGATCTGATTGAGGCAGTGTCGACGCTCAGGACCAAACAAAGGGTTATCCGTCAA
GATATGCAGGACCGCGATATTTTCGGCTACTACGTGGACAAGGGCTGGATGTGTGTTCAGGTTTTCTTTGTCCGCCAAGG
GAAACTCATCCAGCGTGATGTCAATATGTTCCCTTACTATAATGATGCTGAGGAAGATTTTCTAACCTATATGGGTCAAT
TTTACTTGGATAGCCGTCATCTCAAGCCTAAGGAGATTTTCATTCCAGGAGATATTGATCAAGAGTCTGTCGAAGCTCTG
GTCGGAGATGAAGTCAAGGTTTTTAAACCGCAAAGAGGCGAGAAAAAGCAGTTGGTTAATCTGGCAACGAAAAATGCTCG
TGTCAGTTTGACCCAAAAATTTGATCTTCTTGAAAAAGATATAGCTAAGACCCAAGGAGCCATTGAAAATCTAGGAAAAC
TCATGGGAATTCCGACACCGGTTCGCATCGAGTCCTTCGATAACTCTAACATCATGGGAACGAGCCCTGTATCTGCCATG
GTCGTTTTTGAGAACGGCAAACCTAATAAAAAAGAGTACCGCAAATACAAGATTAAGACGGTTGAAGGGCCTGACGATTA
TGCCAGCATGCGTGAGGTCATTCGTCGCCGTTATAGTCGTGTCAAACGTGATGGTCTAACCCCACCAGACCTCATTATAA
TAGATGGTGGTCAAGGTCAGGTCAATGTCGCTAAGGACGTGCTTCGTAATGAGCTGAATCTATCTATCCCGGTTGCAGGT
CTTCAGAAAAATGACAAGCACCAAACCAATGAATTGCTCTTTGGAGATCCTTTGCGAGTCATTGATTTGCCACGTCAATC
CGAGGAGTTTTTCCTCCTTCATCGTATTCAGGATGAAGTACACCGCTTTGCCATCACCTTCCATCGACAAGTCCGTAGTA
AGAATAGTTTCAGTTCCAAACTTGATGGCGTGGAGGGGTTGGGACCTAAACGCAAACAAAAACTCCTCAAAAACTTCAAA
TCAATGACAGCTATCCAACAAGCCAGTGTCGAAGACATCCAAGCTCTTGGAATTCCTGAAAAAGTAGCTCAAGCTTTATT
AGATAAGTTGAGCCAAGATAGTCATTAA

Domains

Predicted by InterProScan.

Helix-hairpin-helix domain (HHH_5)

(540-590)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(375-525)

GIY-YIG catalytic domain (GIY-YIG)

(16-87)

UvrB/uvrC motif (UVR)

(196-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q5LZ62

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

76.481

99.328

0.76
  uvrC Streptococcus pneumoniae R6

76.142

99.328

0.756
  uvrC Streptococcus pneumoniae D39

76.142

99.328

0.756