Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   MGAS1882_RS06215 Genome accession   NC_017053
Coordinates   1257220..1258545 (-) Length   441 a.a.
NCBI ID   WP_014411885.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS1882     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1252220..1263545
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS1882_RS06205 (MGAS1882_1282) hpf 1255955..1256503 (-) 549 WP_002988974.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  MGAS1882_RS06210 (MGAS1882_1283) - 1256583..1257248 (-) 666 WP_002983685.1 ComF family protein -
  MGAS1882_RS06215 (MGAS1882_1284) comFA/cflA 1257220..1258545 (-) 1326 WP_014411885.1 DEAD/DEAH box helicase Machinery gene
  MGAS1882_RS06220 (MGAS1882_1285) - 1258601..1259233 (+) 633 WP_009880468.1 YigZ family protein -
  MGAS1882_RS06225 (MGAS1882_1286) cysK 1259361..1260302 (+) 942 WP_011888673.1 cysteine synthase A -
  MGAS1882_RS06230 (MGAS1882_1287) - 1260320..1260697 (-) 378 WP_009880466.1 S1 RNA-binding domain-containing protein -
  MGAS1882_RS06235 (MGAS1882_1288) - 1260697..1262097 (-) 1401 WP_014411886.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  MGAS1882_RS06240 (MGAS1882_1289) - 1262134..1262775 (-) 642 WP_002983671.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 49788.32 Da        Isoelectric Point: 9.9935

>NTDB_id=44539 MGAS1882_RS06215 WP_014411885.1 1257220..1258545(-) (comFA/cflA) [Streptococcus pyogenes MGAS1882]
MESIENSYGRLLLESQLPDSAKQLAQPLKSVVILRGKMICQRCHYQLDEEARLPSGAYYCRFCLVFGRNQSDKLLYAIPP
MHFPKSNYLVWSGQLTAYQEIISQQLLINMQNQKTTLVHAVTGAGKTEMIYAAIEAVINTGGWVCIASPRVDVCVEVATR
LSQAFSCSICLMHAESLPYQRAPIIVATTHQLLKFHKAFDLLIIDEVDGFPFVNNIQLHYAASQALKEGGAKILLTATST
RTLERKVNKGEVVKLTLARRFHNRPLVIPKFIRSFNLFKMIHRQKLPPKILKYLKKQRKTGYPLLIFLPTIIMAESVTAI
LKELLPAEQIACVSSQSQNRKEDITAFRQGKKTILITTTILERGVTFPQIDVFVLGSHHRVYSSQSLVQIAGRVGRSIDR
PDGTLYFFHEGISKAMLLAKKEIKEMNYKGYSHDLSTMSTN

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=44539 MGAS1882_RS06215 WP_014411885.1 1257220..1258545(-) (comFA/cflA) [Streptococcus pyogenes MGAS1882]
ATGGAGTCTATTGAAAATAGTTATGGACGGTTGTTGCTAGAAAGCCAGTTACCAGATTCAGCAAAGCAGCTTGCTCAACC
TTTAAAAAGTGTAGTAATATTGAGAGGAAAAATGATTTGTCAACGTTGTCACTATCAGCTTGATGAAGAAGCACGATTGC
CAAGTGGAGCCTATTATTGCCGATTTTGTCTTGTCTTTGGACGAAATCAATCAGATAAATTGCTCTATGCTATCCCACCT
ATGCATTTTCCAAAAAGTAATTATCTGGTTTGGAGCGGTCAACTAACTGCTTATCAAGAGATAATTTCCCAACAATTATT
AATCAATATGCAAAATCAAAAAACAACATTAGTTCATGCTGTAACTGGTGCAGGAAAAACAGAAATGATTTATGCTGCGA
TTGAGGCGGTAATTAACACAGGTGGCTGGGTTTGCATTGCCAGCCCAAGAGTAGATGTTTGTGTAGAGGTGGCTACTCGT
TTATCCCAAGCCTTCTCCTGCAGCATCTGTTTAATGCACGCAGAGTCTCTTCCTTATCAAAGAGCTCCTATTATAGTAGC
CACAACGCATCAGCTGCTAAAATTTCACAAGGCTTTTGATCTCTTAATTATTGATGAAGTAGACGGATTCCCTTTTGTAA
ATAATATTCAACTTCATTATGCTGCAAGTCAGGCTTTAAAAGAAGGTGGCGCAAAGATTTTATTAACTGCAACTTCAACT
AGAACTTTAGAAAGAAAGGTAAACAAGGGAGAAGTAGTCAAGCTGACATTGGCGAGACGCTTTCATAATAGGCCATTAGT
TATTCCAAAATTTATAAGAAGTTTTAATCTATTTAAAATGATACATCGGCAAAAACTTCCTCCTAAAATTTTAAAATACT
TAAAAAAACAAAGAAAAACAGGCTATCCCCTTTTAATTTTTCTACCCACTATTATAATGGCAGAATCTGTTACAGCAATC
TTAAAAGAGTTATTGCCCGCCGAACAAATAGCTTGTGTTTCTAGTCAATCACAAAACAGGAAAGAAGATATCACAGCTTT
TCGTCAAGGGAAAAAAACGATTTTAATTACAACAACAATTTTAGAAAGAGGTGTGACATTTCCCCAAATTGATGTTTTTG
TTCTTGGGTCTCATCATCGTGTCTATAGTTCCCAAAGTCTTGTTCAAATTGCTGGACGAGTTGGAAGATCTATAGACAGA
CCAGACGGAACGTTATATTTCTTTCATGAAGGTATCAGTAAAGCAATGCTACTAGCAAAAAAAGAGATTAAAGAAATGAA
TTATAAAGGGTATTCGCATGATCTGTCTACTATGTCAACAAATTAG

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(289-396)

DEAD/DEAH box helicase (DEAD)

(99-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

53.938

95.011

0.512
  comFA/cflA Streptococcus pneumoniae D39

53.938

95.011

0.512
  comFA/cflA Streptococcus pneumoniae R6

53.938

95.011

0.512
  comFA/cflA Streptococcus pneumoniae TIGR4

53.938

95.011

0.512
  comFA/cflA Streptococcus mitis NCTC 12261

52.607

95.692

0.503
  comFA/cflA Streptococcus mitis SK321

51.659

95.692

0.494
  comFA Lactococcus lactis subsp. cremoris KW2

47.475

89.796

0.426
  comFA Latilactobacillus sakei subsp. sakei 23K

39.08

98.639

0.385

Multiple sequence alignment