Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   HKM25_RS09860 Genome accession   NZ_CP053210
Coordinates   1931999..1933036 (-) Length   345 a.a.
NCBI ID   WP_000727277.1    Uniprot ID   A0A0B7LHQ0
Organism   Streptococcus pneumoniae strain 6A-10     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 1926999..1938036
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HKM25_RS09835 (HKM25_2016) - 1927738..1929069 (-) 1332 WP_000390043.1 hemolysin family protein -
  HKM25_RS09840 (HKM25_2017) endA 1929360..1930184 (-) 825 WP_001036789.1 DNA-entry nuclease EndA Machinery gene
  HKM25_RS09845 (HKM25_2018) - 1930223..1930411 (-) 189 WP_001036519.1 DNA-directed RNA polymerase subunit beta -
  HKM25_RS09850 (HKM25_2019) murA 1930404..1931687 (-) 1284 WP_000358024.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
  HKM25_RS09855 (HKM25_2020) - 1931711..1931941 (-) 231 WP_000250394.1 DUF1146 family protein -
  HKM25_RS09860 (HKM25_2021) sepM 1931999..1933036 (-) 1038 WP_000727277.1 SepM family pheromone-processing serine protease Regulator
  HKM25_RS09865 (HKM25_2022) coaD 1933020..1933508 (-) 489 WP_001280745.1 pantetheine-phosphate adenylyltransferase -
  HKM25_RS09870 (HKM25_2023) rsmD 1933498..1934037 (-) 540 WP_000706963.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  HKM25_RS09875 (HKM25_2024) asnA 1934102..1935094 (-) 993 WP_000747990.1 aspartate--ammonia ligase -
  HKM25_RS09880 (HKM25_2025) - 1935206..1935889 (-) 684 WP_001016917.1 Bax inhibitor-1/YccA family protein -
  HKM25_RS09885 (HKM25_2026) - 1935945..1936685 (-) 741 WP_000152682.1 RNA methyltransferase -
  HKM25_RS09890 (HKM25_2027) - 1936719..1936997 (+) 279 WP_001174613.1 acylphosphatase -
  HKM25_RS09895 (HKM25_2028) yidC 1937075..1938001 (+) 927 WP_000835943.1 membrane protein insertase YidC -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37537.57 Da        Isoelectric Point: 5.0724

>NTDB_id=443468 HKM25_RS09860 WP_000727277.1 1931999..1933036(-) (sepM) [Streptococcus pneumoniae strain 6A-10]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=443468 HKM25_RS09860 WP_000727277.1 1931999..1933036(-) (sepM) [Streptococcus pneumoniae strain 6A-10]
ATGAAAAAAAAGATTAGATGGCCCTTGTATGTTATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGGAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(130-193)

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(230-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LHQ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

59.649

99.13

0.591