Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   IQS21_RS12690 Genome accession   NZ_CP063483
Coordinates   2656500..2657156 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain EM03-18-08     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2651500..2662156
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IQS21_RS12660 (IQS21_12680) dcyD 2652379..2653365 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  IQS21_RS12665 (IQS21_12685) tcyL 2653380..2654048 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  IQS21_RS12670 (IQS21_12690) tcyN 2654045..2654797 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  IQS21_RS12675 (IQS21_12695) sdiA 2655027..2655749 (+) 723 WP_001154260.1 transcriptional regulator SdiA -
  IQS21_RS12680 (IQS21_12700) yecF 2655817..2656041 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  IQS21_RS12685 (IQS21_12705) yecU 2656028..2656204 (-) 177 WP_000590344.1 protein YecU -
  IQS21_RS24470 - 2656242..2656358 (-) 117 WP_001302039.1 hypothetical protein -
  IQS21_RS12690 (IQS21_12710) letA 2656500..2657156 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  IQS21_RS12695 (IQS21_12715) uvrC 2657153..2658985 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  IQS21_RS12700 (IQS21_12720) pgsA 2659042..2659590 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  IQS21_RS12720 (IQS21_12740) yecA 2660239..2660904 (+) 666 WP_000847902.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=440000 IQS21_RS12690 WP_000611328.1 2656500..2657156(+) (letA) [Escherichia coli strain EM03-18-08]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=440000 IQS21_RS12690 WP_000611328.1 2656500..2657156(+) (letA) [Escherichia coli strain EM03-18-08]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482