Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   IQS23_RS03725 Genome accession   NZ_CP063476
Coordinates   772966..773622 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain EM10-18-28     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 767966..778622
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IQS23_RS03695 (IQS23_03695) dcyD 768846..769832 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  IQS23_RS03700 (IQS23_03700) tcyL 769847..770515 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  IQS23_RS03705 (IQS23_03705) tcyN 770512..771264 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  IQS23_RS03710 (IQS23_03710) sdiA 771494..772216 (+) 723 WP_001154265.1 transcriptional regulator SdiA -
  IQS23_RS03715 (IQS23_03715) yecF 772283..772507 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  IQS23_RS03720 (IQS23_03720) yecU 772494..772670 (-) 177 WP_000590344.1 protein YecU -
  IQS23_RS24870 - 772708..772824 (-) 117 WP_023063716.1 hypothetical protein -
  IQS23_RS03725 (IQS23_03725) letA 772966..773622 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  IQS23_RS03730 (IQS23_03730) uvrC 773619..775451 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  IQS23_RS03735 (IQS23_03735) pgsA 775508..776056 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  IQS23_RS03755 (IQS23_03755) yecA 776706..777371 (+) 666 WP_000847880.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=439792 IQS23_RS03725 WP_000611328.1 772966..773622(+) (letA) [Escherichia coli strain EM10-18-28]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=439792 IQS23_RS03725 WP_000611328.1 772966..773622(+) (letA) [Escherichia coli strain EM10-18-28]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTTGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482