Detailed information
Bioinformatically predicted
Overview
| Name | sepM | Type | Regulator |
| Locus tag | HEQ84_RS07780 | Genome accession | NZ_CP050870 |
| Coordinates | 1506881..1507957 (-) | Length | 358 a.a. |
| NCBI ID | WP_011681549.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain CS6 | ||
| Function | processing of CSP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1492134..1564932 | 1506881..1507957 | within | 0 |
Gene organization within MGE regions
Location: 1492134..1564932
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HEQ84_RS07705 (HEQ84_07725) | - | 1493025..1493576 (-) | 552 | WP_002946999.1 | isochorismatase family cysteine hydrolase | - |
| HEQ84_RS07710 (HEQ84_07730) | codY | 1493639..1494424 (-) | 786 | WP_002951720.1 | GTP-sensing pleiotropic transcriptional regulator CodY | - |
| HEQ84_RS07715 (HEQ84_07735) | - | 1494684..1495898 (-) | 1215 | WP_002951721.1 | pyridoxal phosphate-dependent aminotransferase | - |
| HEQ84_RS07720 (HEQ84_07740) | - | 1496253..1496705 (+) | 453 | WP_002946987.1 | universal stress protein | - |
| HEQ84_RS07725 (HEQ84_07745) | - | 1496885..1497456 (+) | 572 | Protein_1479 | IS30 family transposase | - |
| HEQ84_RS07730 (HEQ84_07750) | - | 1497528..1497701 (-) | 174 | WP_011681546.1 | hypothetical protein | - |
| HEQ84_RS07735 (HEQ84_07755) | - | 1497762..1498136 (-) | 375 | WP_011681547.1 | membrane protein | - |
| HEQ84_RS07740 (HEQ84_07760) | pflA | 1498348..1499148 (-) | 801 | WP_002946980.1 | pyruvate formate-lyase-activating protein | - |
| HEQ84_RS07745 (HEQ84_07765) | - | 1499336..1499446 (-) | 111 | WP_014621906.1 | LPXTG cell wall anchor domain-containing protein | - |
| HEQ84_RS07750 (HEQ84_07770) | - | 1500144..1501475 (-) | 1332 | WP_024703987.1 | hemolysin family protein | - |
| HEQ84_RS07755 (HEQ84_07775) | - | 1501589..1502371 (+) | 783 | WP_024703988.1 | ABC transporter ATP-binding protein | - |
| HEQ84_RS07760 (HEQ84_07780) | - | 1502993..1505059 (-) | 2067 | WP_011681548.1 | sodium:proton antiporter | - |
| HEQ84_RS07765 (HEQ84_07785) | - | 1505068..1505310 (-) | 243 | WP_011226461.1 | hypothetical protein | - |
| HEQ84_RS07770 (HEQ84_07790) | - | 1505307..1505855 (-) | 549 | WP_011226462.1 | class I SAM-dependent methyltransferase | - |
| HEQ84_RS07775 (HEQ84_07795) | - | 1505852..1506796 (-) | 945 | WP_011226463.1 | TIGR01212 family radical SAM protein | - |
| HEQ84_RS07780 (HEQ84_07800) | sepM | 1506881..1507957 (-) | 1077 | WP_011681549.1 | SepM family pheromone-processing serine protease | Regulator |
| HEQ84_RS07785 (HEQ84_07805) | coaD | 1507935..1508432 (-) | 498 | WP_011681550.1 | pantetheine-phosphate adenylyltransferase | - |
| HEQ84_RS07790 (HEQ84_07810) | rsmD | 1508466..1509065 (-) | 600 | Protein_1492 | 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD | - |
| HEQ84_RS07795 (HEQ84_07815) | trxB | 1509156..1510109 (-) | 954 | WP_255136104.1 | thioredoxin-disulfide reductase | - |
| HEQ84_RS07800 (HEQ84_07820) | - | 1510142..1510366 (-) | 225 | WP_014621911.1 | DUF4059 family protein | - |
| HEQ84_RS07805 (HEQ84_07825) | - | 1510581..1511324 (-) | 744 | WP_014608652.1 | amino acid ABC transporter ATP-binding protein | - |
| HEQ84_RS07810 (HEQ84_07830) | - | 1511324..1512070 (-) | 747 | WP_100284797.1 | amino acid ABC transporter permease | - |
| HEQ84_RS07815 (HEQ84_07835) | - | 1512458..1513288 (-) | 831 | WP_014608653.1 | transporter substrate-binding domain-containing protein | - |
| HEQ84_RS07820 (HEQ84_07840) | - | 1513748..1513981 (-) | 234 | WP_002947030.1 | hypothetical protein | - |
| HEQ84_RS07825 (HEQ84_07845) | dinB | 1514279..1515382 (-) | 1104 | WP_014608654.1 | DNA polymerase IV | - |
| HEQ84_RS07830 (HEQ84_07850) | pflB | 1515661..1517970 (+) | 2310 | WP_011226473.1 | formate C-acetyltransferase | - |
| HEQ84_RS07835 (HEQ84_07855) | - | 1518237..1519019 (+) | 783 | WP_011681555.1 | carbonic anhydrase family protein | - |
| HEQ84_RS07840 (HEQ84_07860) | - | 1519070..1519522 (+) | 453 | WP_014608655.1 | GNAT family N-acetyltransferase | - |
| HEQ84_RS07845 (HEQ84_07865) | - | 1519873..1520178 (-) | 306 | WP_014621914.1 | restriction endonuclease subunit S | - |
| HEQ84_RS09780 (HEQ84_07870) | mobV | 1520203..1520711 (-) | 509 | Protein_1504 | MobV family relaxase | - |
| HEQ84_RS07855 (HEQ84_07875) | fetB | 1521156..1521911 (-) | 756 | WP_011681558.1 | iron export ABC transporter permease subunit FetB | - |
| HEQ84_RS07860 (HEQ84_07880) | - | 1521908..1522558 (-) | 651 | WP_024703990.1 | ATP-binding cassette domain-containing protein | - |
| HEQ84_RS07865 (HEQ84_07885) | - | 1522761..1523717 (-) | 957 | WP_024703991.1 | serine hydrolase domain-containing protein | - |
| HEQ84_RS07870 (HEQ84_07890) | - | 1523717..1524472 (-) | 756 | WP_011681560.1 | CppA family protein | - |
| HEQ84_RS07875 (HEQ84_07895) | - | 1524754..1525116 (+) | 363 | WP_014608659.1 | CPBP family intramembrane glutamic endopeptidase | - |
| HEQ84_RS07880 (HEQ84_07900) | gla | 1525203..1526066 (-) | 864 | WP_002951781.1 | aquaglyceroporin Gla | - |
| HEQ84_RS07885 (HEQ84_07905) | - | 1526187..1528454 (+) | 2268 | WP_011681561.1 | Xaa-Pro dipeptidyl-peptidase | - |
| HEQ84_RS07890 (HEQ84_07910) | - | 1528534..1528914 (-) | 381 | WP_002951783.1 | hypothetical protein | - |
| HEQ84_RS07895 (HEQ84_07915) | - | 1529039..1529302 (-) | 264 | WP_002945924.1 | hypothetical protein | - |
| HEQ84_RS07900 (HEQ84_07920) | - | 1529624..1529920 (-) | 297 | WP_004197070.1 | bacteriocin immunity protein | - |
| HEQ84_RS07905 (HEQ84_07925) | - | 1530085..1530291 (-) | 207 | WP_011681562.1 | hypothetical protein | - |
| HEQ84_RS07910 (HEQ84_07930) | - | 1530322..1531014 (-) | 693 | WP_224103184.1 | thioredoxin family protein | - |
| HEQ84_RS07915 (HEQ84_07935) | - | 1531205..1532775 (+) | 1571 | WP_106693466.1 | IS3-like element ISSth1b family transposase | - |
| HEQ84_RS07920 (HEQ84_07940) | - | 1532921..1533175 (-) | 255 | WP_014608660.1 | Blp family class II bacteriocin | - |
| HEQ84_RS09785 | - | 1533426..1533827 (-) | 402 | WP_024703992.1 | hypothetical protein | - |
| HEQ84_RS07925 (HEQ84_07945) | - | 1534832..1535062 (-) | 231 | WP_014608662.1 | bacteriocin class II family protein | - |
| HEQ84_RS07930 (HEQ84_07950) | - | 1535418..1535618 (-) | 201 | WP_011681569.1 | hypothetical protein | - |
| HEQ84_RS07935 (HEQ84_07955) | - | 1535637..1535813 (-) | 177 | WP_011681570.1 | Blp family class II bacteriocin | - |
| HEQ84_RS07940 (HEQ84_07960) | - | 1536069..1536800 (+) | 732 | WP_002948869.1 | LytTR family DNA-binding domain-containing protein | - |
| HEQ84_RS07945 | - | 1537337..1538140 (+) | 804 | WP_224107502.1 | ATP-binding protein | - |
| HEQ84_RS07950 (HEQ84_07970) | - | 1538158..1538319 (-) | 162 | WP_011681573.1 | ComC/BlpC family leader-containing pheromone/bacteriocin | - |
| HEQ84_RS07955 (HEQ84_07975) | - | 1538334..1539701 (-) | 1368 | WP_011681574.1 | bacteriocin secretion accessory protein | - |
| HEQ84_RS07960 (HEQ84_07980) | - | 1539717..1541869 (-) | 2153 | Protein_1527 | peptide cleavage/export ABC transporter | - |
| HEQ84_RS07965 (HEQ84_07990) | - | 1542883..1544628 (-) | 1746 | WP_024703994.1 | ABC transporter ATP-binding protein | - |
| HEQ84_RS07970 (HEQ84_07995) | - | 1544621..1546378 (-) | 1758 | WP_024703995.1 | ABC transporter transmembrane domain-containing protein | - |
| HEQ84_RS07975 | - | 1546566..1546772 (-) | 207 | WP_002948879.1 | hypothetical protein | - |
| HEQ84_RS07980 (HEQ84_08005) | - | 1546977..1547504 (-) | 528 | WP_011226503.1 | VanZ family protein | - |
| HEQ84_RS07985 (HEQ84_08010) | rlmN | 1547506..1548675 (-) | 1170 | WP_011226504.1 | 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN | - |
| HEQ84_RS07990 (HEQ84_08015) | - | 1548679..1549401 (-) | 723 | WP_024703996.1 | YutD family protein | - |
| HEQ84_RS07995 (HEQ84_08020) | - | 1549456..1550811 (-) | 1356 | WP_002948886.1 | metallophosphatase | - |
| HEQ84_RS08000 (HEQ84_08025) | - | 1551659..1553002 (-) | 1344 | WP_014608670.1 | DEAD/DEAH box helicase | - |
| HEQ84_RS08005 (HEQ84_08030) | mraY | 1553077..1554099 (-) | 1023 | WP_011227524.1 | phospho-N-acetylmuramoyl-pentapeptide- transferase | - |
| HEQ84_RS08010 (HEQ84_08035) | pbp2X | 1554101..1556368 (-) | 2268 | WP_011681584.1 | penicillin-binding protein PBP2X | - |
| HEQ84_RS08015 (HEQ84_08040) | ftsL | 1556372..1556692 (-) | 321 | WP_002948801.1 | cell division protein FtsL | - |
| HEQ84_RS08020 (HEQ84_08045) | rsmH | 1556695..1557645 (-) | 951 | WP_014621931.1 | 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH | - |
| HEQ84_RS08025 | - | 1557811..1558239 (-) | 429 | WP_011681585.1 | hypothetical protein | - |
| HEQ84_RS08030 | - | 1558205..1558420 (-) | 216 | WP_011681586.1 | hypothetical protein | - |
| HEQ84_RS08035 | - | 1558417..1558803 (-) | 387 | WP_011681587.1 | hypothetical protein | - |
| HEQ84_RS08040 (HEQ84_08055) | - | 1558886..1559134 (+) | 249 | WP_011681588.1 | hypothetical protein | - |
| HEQ84_RS08045 (HEQ84_08060) | - | 1559440..1559796 (-) | 357 | WP_014621938.1 | DUF805 domain-containing protein | - |
| HEQ84_RS08050 (HEQ84_08065) | - | 1560015..1560305 (-) | 291 | WP_014621939.1 | hypothetical protein | - |
| HEQ84_RS08055 (HEQ84_08070) | - | 1560639..1561889 (-) | 1251 | WP_014621940.1 | glutamate-5-semialdehyde dehydrogenase | - |
| HEQ84_RS08060 (HEQ84_08075) | proB | 1561891..1562694 (-) | 804 | WP_014621941.1 | glutamate 5-kinase | - |
| HEQ84_RS08065 (HEQ84_08080) | - | 1562815..1564404 (-) | 1590 | WP_014608677.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 358 a.a. Molecular weight: 39172.02 Da Isoelectric Point: 9.3888
>NTDB_id=435384 HEQ84_RS07780 WP_011681549.1 1506881..1507957(-) (sepM) [Streptococcus thermophilus strain CS6]
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
MANKTKSKALLEKMWRIKWWLLSIFTVLFLLFALFFPLNNYYVELPGGAFDTKEVLTVNKKADDSKGSYNFVAVAQTKAT
LALMLYAQFNDFAKLQTAEEATGNYSDEDFMRINQFYMETSQNQAVYQGLTLAGKEVSLEYMGVYVLQVADDSSFKGVLN
IADTVTAVNGNTFDNSTDMIKYVQGLKLGSKVKVTYMRDGKEKTATGKIIKIANGKNGIGIGLTDHTEIKSPENVKFKLD
GVGGPSAGLMFTLAIYDQVSGQDLKAGRKIAGTGTIEKDGAVGDIGGAYLKVKSAADSGADIFFVPNNLVTKEMKKADPD
AKTNYQEAKEAAEKLGTKMKIVPVKTAQEAIDYLKKTK
Nucleotide
Download Length: 1077 bp
>NTDB_id=435384 HEQ84_RS07780 WP_011681549.1 1506881..1507957(-) (sepM) [Streptococcus thermophilus strain CS6]
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
GTGGCAAACAAGACAAAATCTAAAGCGCTATTAGAGAAAATGTGGCGTATTAAGTGGTGGTTATTAAGTATTTTTACGGT
ACTTTTCCTCCTTTTTGCCCTCTTTTTCCCGCTCAATAATTACTATGTGGAGCTTCCGGGTGGTGCTTTTGATACCAAGG
AAGTCTTGACAGTGAATAAGAAAGCTGATGATTCTAAGGGCTCCTATAATTTTGTGGCGGTGGCTCAAACCAAGGCGACT
TTGGCCTTGATGCTCTATGCTCAGTTTAATGATTTTGCAAAGCTTCAAACGGCTGAAGAGGCAACTGGAAATTACTCTGA
TGAAGATTTCATGCGCATCAACCAATTTTACATGGAGACTTCTCAAAACCAAGCGGTTTATCAGGGCTTGACTCTGGCTG
GTAAGGAGGTTAGTTTGGAGTATATGGGTGTCTATGTGCTTCAGGTTGCTGATGATTCTAGCTTCAAGGGTGTCCTCAAT
ATTGCTGATACGGTGACGGCTGTTAATGGTAATACCTTTGATAATTCTACTGACATGATTAAATACGTTCAAGGACTTAA
GCTGGGTTCAAAGGTCAAGGTCACTTATATGAGAGATGGCAAAGAAAAGACTGCTACTGGTAAGATTATTAAGATTGCCA
ATGGCAAAAATGGTATTGGTATCGGCCTAACGGACCATACTGAGATCAAGAGTCCTGAGAATGTTAAGTTTAAACTGGAT
GGTGTCGGTGGGCCAAGTGCTGGTCTTATGTTTACCTTGGCTATTTACGATCAGGTGTCTGGTCAAGACCTCAAGGCTGG
CCGCAAGATTGCTGGTACAGGAACTATTGAAAAAGATGGGGCTGTCGGTGATATCGGTGGGGCCTATCTCAAGGTGAAAT
CTGCGGCTGATAGTGGCGCAGACATTTTCTTCGTGCCAAATAATCTAGTAACTAAGGAAATGAAAAAGGCTGATCCGGAT
GCCAAGACTAATTATCAAGAGGCCAAGGAAGCTGCCGAGAAACTGGGGACCAAGATGAAAATCGTCCCTGTTAAAACAGC
TCAAGAAGCCATTGATTATTTGAAAAAGACTAAATGA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| sepM | Streptococcus mutans UA159 |
62.757 |
95.251 |
0.598 |