Detailed information NTG0043370

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: SCIM_RS09025
• Genome accession: NC_018073
• Coordinates: 1835281..1837839 (-)
• Length: 852 a.a.
• NCBI ID: WP_003077322.1
• Uniprot ID: -
• Organism: Streptococcus intermedius JTH08
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1830281..1842839

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCIM_RS09000 (SCIM_1617)	-	1830514..1831329 (+)	816	WP_003077212.1	DnaD domain protein	-
SCIM_RS09005 (SCIM_1618)	-	1831345..1832169 (+)	825	WP_003077200.1	ATP-binding protein	-
SCIM_RS09010 (SCIM_1619)	-	1832900..1833325 (+)	426	WP_003077305.1	DUF1492 domain-containing protein	-
SCIM_RS09015 (SCIM_1620)	brsR	1834245..1834685 (+)	441	WP_014829834.1	LytTR family DNA-binding domain-containing protein	Regulator
SCIM_RS09020 (SCIM_1621)	-	1834682..1835140 (+)	459	WP_003075329.1	DUF3021 domain-containing protein	-
SCIM_RS09025 (SCIM_1622)	hexA	1835281..1837839 (-)	2559	WP_003077322.1	DNA mismatch repair protein MutS	Machinery gene
SCIM_RS09030 (SCIM_1623)	argR	1838002..1838442 (-)	441	WP_003075336.1	arginine repressor	-
SCIM_RS09035 (SCIM_1624)	argS	1838546..1840234 (+)	1689	WP_003077172.1	arginine--tRNA ligase	-
SCIM_RS09040 (SCIM_1625)	nrdI	1840286..1840741 (-)	456	WP_003077379.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
SCIM_RS09045 (SCIM_1626)	-	1840817..1841326 (-)	510	WP_003077356.1	hypothetical protein	-

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 96193.63 Da
• Isoelectric Point: 4.9033

>NTDB_id=43370 SCIM_RS09025 WP_003077322.1 1835281..1837839(-) (hexA) [Streptococcus intermedius JTH08]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAINAAQILEIALTSRNKNSEKPIPMAGVPYHSVQQYIDVLI
ESGYKVAIAEQVEDPKKAVGVVKREVVQVITPGTAVDSSKPDSQNNFLVALDKLEDFYGLAYMDVVTGEFQVTTLSDFNM
VCGEIRNLRAREVVLGYELPEAEHQVLANQMNLLLSQVETAFEDVQLLGDDLSRLEYQVAGKLLEYVHQTQLRELSHLKQ
VHHYEIKDFLQMDYATMTSLDLTENARTGKKHGSLYWLMDETKTAMGTRLLRRWIQHPLLDKERILKRQDVVQVFLDHFF
ERSDLADSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSNVPQIKGILQGIDHPVLGQLIENLDDIPELANLIQSAISP
DAPNVITEGNIIQTGFDETLDKYRVVLRDGTSWIADIEAKERVASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFIRIREEAGKYIKRLQSLAQTLATVDVLQSFAAVAEKQRFVRPEFI
ERPSIEIDKGRHAVVEKVMGAQTYIPNSISMDENVNLQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVSAERAQLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANHAISQATEHSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TDLSTSLTQLENVHVATVEKDGKVTFLHKIEAGPADKSYGIHVARIAGLPDDLLMRADQILARLEEQANEKPSLNPSNKG
ANDSKENQVFEQISLFTETTESPILDELRQLDIYNMTPMEVMLAIAEMKKHL

Nucleotide

• Length: 2559 bp

>NTDB_id=43370 SCIM_RS09025 WP_003077322.1 1835281..1837839(-) (hexA) [Streptococcus intermedius JTH08]
ATGACAAAAGAAAAACTATCTCCGGGAATGCAACAGTATTTAGATATAAAAAAAGATTATCCGGATGCTTTTTTGCTATT
TCGCATGGGAGATTTTTATGAATTATTCTATGAAGATGCGATCAATGCAGCACAGATTTTAGAAATTGCTCTGACTAGCC
GTAATAAAAATTCGGAAAAGCCAATTCCGATGGCAGGAGTTCCCTATCATTCGGTGCAACAATATATTGATGTTTTAATT
GAATCGGGCTATAAAGTAGCGATTGCAGAGCAGGTGGAAGATCCTAAAAAAGCAGTTGGTGTAGTCAAACGTGAGGTGGT
ACAAGTCATCACACCGGGGACAGCCGTTGATTCTTCAAAACCAGATAGTCAAAATAATTTCTTGGTAGCTTTAGATAAGC
TAGAAGATTTCTATGGGCTAGCTTATATGGATGTGGTAACTGGTGAATTTCAGGTGACAACTCTCAGTGACTTTAACATG
GTTTGTGGGGAAATTCGAAACCTACGAGCGCGTGAAGTGGTATTGGGATATGAATTACCTGAAGCAGAGCACCAAGTGTT
GGCAAATCAAATGAATTTGTTATTATCACAGGTGGAAACTGCTTTTGAAGATGTTCAGCTATTAGGAGATGATTTGTCTC
GCCTAGAATATCAAGTAGCTGGGAAACTGTTAGAATATGTTCACCAGACGCAGCTGCGTGAGCTTAGTCACTTAAAGCAA
GTTCATCATTATGAAATTAAAGATTTCTTACAGATGGACTATGCAACTATGACAAGTCTAGATTTAACAGAGAATGCACG
GACGGGGAAGAAGCATGGCAGTCTTTATTGGTTGATGGACGAGACCAAGACAGCTATGGGGACGCGACTTCTAAGAAGAT
GGATCCAGCATCCGTTGCTTGATAAGGAACGGATTCTTAAGCGGCAGGATGTCGTACAAGTCTTTTTAGATCATTTTTTT
GAGCGTAGTGATTTGGCAGATAGTCTCAAAGGGGTTTATGATATTGAGCGCTTGGCAAGCCGTGTTTCTTTTGGGAAGAC
AAACCCGAAGGATTTATTGCAGTTGGCGGCAACATTGAGCAATGTCCCTCAGATTAAGGGAATTTTACAAGGAATCGATC
ATCCTGTTTTGGGACAGTTGATTGAAAACTTGGATGATATTCCAGAATTGGCAAACTTGATTCAGTCGGCAATTTCTCCT
GATGCTCCAAATGTTATTACGGAAGGGAATATCATTCAAACTGGTTTTGATGAAACCTTAGATAAGTATCGAGTGGTTCT
GCGAGATGGTACGAGCTGGATTGCTGATATTGAAGCGAAAGAAAGGGTGGCTAGTGGGATTAATAATCTAAAAATTGATT
ACAATAAAAAAGACGGTTATTATTTCCATGTTACTAATTCACAGTTGGAGCACGTACCTAGCCACTTTTTCCGAAAAGCA
ACGTTGAAAAATTCAGAACGATTTGGTACAGAGGAATTGGCTCGTATTGAAGGCGAAATGTTGGAAGCGCGTGAAAAATC
GGCCAATTTAGAGTATGAGATTTTTATACGTATTCGGGAAGAAGCTGGTAAATATATCAAACGATTACAATCCTTGGCAC
AAACTCTAGCAACAGTGGATGTATTGCAGAGTTTTGCAGCAGTTGCTGAAAAGCAACGCTTTGTACGCCCAGAATTTATT
GAACGTCCTTCCATTGAAATCGATAAGGGACGGCATGCAGTTGTAGAAAAGGTTATGGGTGCACAAACTTATATTCCGAA
TAGTATTTCAATGGATGAGAATGTCAATCTTCAGTTAATTACAGGTCCAAATATGAGTGGGAAGTCAACCTATATGCGGC
AATTAGCGATTATTGTTATCATGGCGCAAATGGGTTCCTATGTTTCAGCTGAACGTGCTCAATTACCAATTTTTGATGCC
ATCTTCACTCGAATTGGTGCAGCAGATGACTTGGTATCTGGGCAATCAACCTTTATGGTAGAAATGATGGAAGCAAATCA
TGCTATTTCTCAAGCGACTGAACACTCTCTTATTCTTTTTGATGAGTTGGGGAGAGGGACAGCAACATATGATGGGATGG
CTCTTGCTCAGGCAATTATTGAATATATCCACAATCGAACAGGAGCAAAGACCCTTTTTGCTACACACTATCATGAGTTG
ACAGACTTGTCAACTAGCTTGACACAGTTAGAAAATGTTCATGTAGCAACTGTAGAAAAAGATGGGAAAGTGACCTTCCT
TCATAAGATTGAAGCTGGTCCTGCAGATAAATCTTATGGGATTCATGTCGCAAGAATTGCAGGTTTACCAGATGATTTGT
TGATGAGAGCCGACCAGATACTAGCAAGACTAGAAGAACAAGCAAATGAGAAACCATCTCTCAATCCTTCTAATAAAGGA
GCTAATGATAGTAAAGAAAATCAAGTATTTGAGCAGATATCTTTATTCACAGAAACAACTGAATCACCTATTTTAGATGA
ACTACGTCAGTTGGATATTTATAATATGACCCCAATGGAAGTGATGCTAGCTATAGCTGAGATGAAAAAACATCTCTGA

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (255-546)

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	75.235	100	0.752
mutS	Pseudomonas stutzeri strain ATCC 17587	36.195	100	0.366