Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SCIM_RS08910 Genome accession   NC_018073
Coordinates   1818539..1820485 (-) Length   648 a.a.
NCBI ID   WP_003077366.1    Uniprot ID   -
Organism   Streptococcus intermedius JTH08     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1813539..1825485
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCIM_RS10140 - 1815012..1815333 (+) 322 Protein_1722 transposase -
  SCIM_RS08885 (SCIM_1599) - 1815406..1816064 (-) 659 Protein_1723 lysostaphin resistance A-like protein -
  SCIM_RS08890 (SCIM_1600) - 1816069..1816623 (-) 555 WP_003077403.1 DNA-3-methyladenine glycosylase I -
  SCIM_RS08895 (SCIM_1601) ruvA 1816634..1817224 (-) 591 WP_003077156.1 Holliday junction branch migration protein RuvA Machinery gene
  SCIM_RS08900 (SCIM_1602) - 1817394..1817900 (+) 507 WP_037589496.1 helix-turn-helix domain-containing protein -
  SCIM_RS08905 (SCIM_1603) - 1817884..1818393 (+) 510 WP_003077229.1 RDD family protein -
  SCIM_RS08910 (SCIM_1604) hexB 1818539..1820485 (-) 1947 WP_003077366.1 DNA mismatch repair endonuclease MutL Machinery gene
  SCIM_RS08915 (SCIM_1605) - 1820581..1821726 (-) 1146 WP_003077372.1 tyrosine-type recombinase/integrase -
  SCIM_RS08920 (SCIM_1606) - 1822041..1823096 (-) 1056 WP_003077221.1 Abi family protein -
  SCIM_RS08925 (SCIM_1607) - 1823099..1823569 (-) 471 WP_231840234.1 hypothetical protein -
  SCIM_RS08930 (SCIM_1608) - 1823622..1824290 (-) 669 WP_003077300.1 Fic family protein -
  SCIM_RS08935 - 1824726..1824908 (+) 183 WP_003077353.1 hypothetical protein -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73396.94 Da        Isoelectric Point: 5.0967

>NTDB_id=43368 SCIM_RS08910 WP_003077366.1 1818539..1820485(-) (hexB) [Streptococcus intermedius JTH08]
MSKIIELPEKLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLKSIQVIDNGEGIEHEEVPLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSCLTIETATETDQYGTLLVARGGEIECVEPTSSTVGTKIKVENLFFNTPARLKY
MKSQQAELSHIVDVMNRLSLAHPEIAFTLINDGKKMTQTVGTGNLRQAIAGVYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEYDLIPDALENLAKSTINRVSMPEQTSLPLKENRLYYDQGRTDFFVKPQVSEDRPSFEKTDQLAQQPVAPDMP
DSRTVSIKFAERQAPSYDQLDHPELDQASMERALEKLDREGISTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYRDKIGDVDDSQQQLLVPYIFEFPADDMLRLQQRMSLLEEVGIFLEEYGANQFILREHPIWLKEEEIESGVYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCNNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=43368 SCIM_RS08910 WP_003077366.1 1818539..1820485(-) (hexB) [Streptococcus intermedius JTH08]
ATGTCAAAAATTATAGAATTACCAGAAAAACTTGCCAATCAGATTGCAGCAGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAAAACTCCATTGATGCTGGTGCCACTCAGATTATAGTTGAGATTGAAGAAGCAGGTCTCAAGA
GTATTCAAGTCATTGATAATGGCGAAGGGATTGAGCACGAGGAAGTTCCCTTAGCTTTGCGTCGGCATGCGACGAGTAAG
ATTAAGAAACAAGCCGACCTTTTTCGAATTCGGACGTTGGGTTTTCGCGGTGAGGCACTTCCATCTATCGCTTCCGTTTC
ATGTTTGACGATTGAAACTGCAACAGAGACAGATCAATATGGTACTCTCTTGGTAGCCCGAGGTGGTGAAATTGAGTGTG
TAGAACCAACGAGCAGCACTGTCGGAACAAAAATCAAAGTCGAAAATCTCTTTTTCAATACACCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCCGAATTATCTCATATTGTAGACGTGATGAATCGTTTGAGTTTAGCCCATCCGGAGATTGCTTT
TACTCTAATAAATGACGGTAAAAAAATGACACAAACAGTAGGAACAGGGAATCTACGCCAAGCGATTGCTGGTGTTTATG
GACTGACAACGGCAAAAAAAATGATTGAGATTTCAGCTTCTAATCTGGATTTTGAAGTATCAGGCTATATTAGCCTGCCA
GAACTAACACGAGCTAATCGTAATTATATCACGATTCTCATCAATGGTCGCTATATTAAGAATTTCTTGCTCAATCGAGC
TATCCTTGATGGCTATGGTAGTAAGCTCATGGTGGGGCGTTTTCCGATTGCAGTGATTGCTATTCAGATTGATCCTTACC
TTGCTGATGTCAATGTTCATCCCACTAAGCAAGAAGTACGGATCTCAAAAGAGCGAGAGCTTATGGTCTTGATTTCACAA
GCGATTGCTGCGAGTCTAAAAGAGTATGATTTGATTCCAGATGCTTTGGAGAATTTAGCTAAATCAACTATTAATCGAGT
AAGTATGCCTGAACAGACTAGCTTACCACTAAAGGAGAACCGACTTTATTACGACCAAGGAAGAACCGATTTCTTTGTGA
AACCACAAGTGTCAGAAGATCGACCTTCTTTTGAGAAAACTGACCAATTAGCTCAGCAACCCGTTGCTCCAGATATGCCT
GATTCCAGAACAGTCTCTATTAAATTTGCAGAAAGGCAGGCGCCTTCTTATGACCAACTGGATCATCCTGAGTTAGATCA
AGCTAGTATGGAGAGAGCTTTAGAGAAGCTAGATAGAGAAGGAATATCAACCTTTCCAGAGTTGGAATATTTCGGTCAAA
TGCATGGCACCTATCTCTTTGCACAAGGAAATGGTGGTCTTTATATTATTGACCAGCATGCAGCTCAAGAACGGGTCAAG
TATGAATATTATAGGGACAAAATAGGAGATGTAGATGACAGTCAGCAGCAGCTTTTGGTGCCTTATATTTTTGAATTTCC
GGCAGACGATATGCTGCGACTTCAACAACGAATGTCTCTTTTGGAAGAAGTGGGTATTTTCCTAGAAGAATATGGAGCCA
ATCAATTTATTTTGCGTGAACATCCTATTTGGCTCAAAGAAGAGGAAATTGAGTCAGGTGTCTATGAAATGTGTGATATG
CTGCTTTTGACCAAGGAAGTCTCTATTAAGAAATATCGTGCAGAGCTAGCTATTATGATGAGCTGTAAACGTTCTATTAA
GGCCAATCATAGCTTAGATGACTACTCGGCACGTGATTTAATTTTCCAACTATCACAATGCAACAATCCTTATAACTGTC
CACATGGTCGACCAGTCTTGGTTAACTTTACCAAGTCGGATATGGAAAAAATGTTTCGCCGCATTCAGGAAAATCATACT
AGCCTACGGGAGTTGGGTAAGTATTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.422

100

0.758

Multiple sequence alignment