Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   M594_RS08440 Genome accession   NZ_CP047883
Coordinates   1744479..1745168 (-) Length   229 a.a.
NCBI ID   WP_050105813.1    Uniprot ID   A0A6M9F7A8
Organism   Streptococcus mitis strain S022-V3-A4     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1739479..1750168
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M594_RS08420 (M594_08460) mvaD 1740243..1741196 (-) 954 WP_173876549.1 diphosphomevalonate decarboxylase -
  M594_RS08425 (M594_08465) mvk 1741178..1742056 (-) 879 WP_173876551.1 mevalonate kinase -
  M594_RS08430 (M594_08470) cbpC 1742331..1743350 (-) 1020 WP_173876553.1 choline-binding protein CbpC -
  M594_RS08435 (M594_08475) cbpJ 1743368..1744378 (-) 1011 WP_173876554.1 choline-binding protein CbpJ -
  M594_RS08440 (M594_08480) covR 1744479..1745168 (-) 690 WP_050105813.1 response regulator transcription factor Regulator
  M594_RS08445 (M594_08485) gndA 1745180..1746604 (-) 1425 WP_000158778.1 NADP-dependent phosphogluconate dehydrogenase -
  M594_RS08450 (M594_08490) mapZ 1746680..1748116 (-) 1437 WP_173876555.1 cell division site-positioning protein MapZ -
  M594_RS08455 (M594_08495) - 1748129..1749286 (-) 1158 WP_173876556.1 THUMP domain-containing class I SAM-dependent RNA methyltransferase -
  M594_RS08465 (M594_08505) gpsB 1749773..1750102 (-) 330 WP_173876557.1 cell division regulator GpsB -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26784.92 Da        Isoelectric Point: 8.6485

>NTDB_id=418270 M594_RS08440 WP_050105813.1 1744479..1745168(-) (covR) [Streptococcus mitis strain S022-V3-A4]
MGKRILLLEKERNLAHFLSLELQKEQYRVDQVEEGQKALSMALQTDYDLILLNARLGDMTAQNFADKLSRTKPASVIMVL
DHREELQDQIETIQRFAVSYIYKPVIIDNLVARISAIFRGRDFIDQHCSQMKVPTSYRNLRMDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=418270 M594_RS08440 WP_050105813.1 1744479..1745168(-) (covR) [Streptococcus mitis strain S022-V3-A4]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAAAAAGAGCAATA
CCGAGTTGATCAGGTTGAGGAGGGGCAAAAAGCCCTCTCCATGGCTCTTCAGACAGACTATGACTTGATTTTATTGAATG
CTCGTCTGGGGGATATGACAGCCCAGAATTTTGCAGATAAGCTGAGTCGGACTAAGCCAGCTTCAGTCATCATGGTCTTG
GACCATCGCGAAGAATTGCAAGATCAGATTGAAACAATCCAACGCTTTGCCGTTTCTTACATCTATAAGCCAGTTATTAT
TGATAATTTGGTAGCTCGTATTTCAGCGATTTTCAGAGGTCGGGACTTTATCGACCAACACTGTAGTCAGATGAAGGTTC
CAACATCTTACCGTAATCTGCGTATGGATGTAGAGCATCATACCGTTTATCGTGGCGAGGAGATGATTGCTTTGACTCGT
CGTGAGTATGACCTCTTGGCTACTCTTATGGGAAGCAAGAAAGTTCTGACTCGTGAGCAGTTGTTGGAAAGTGTCTGGAA
GTATGAAAGTGCGACCGAAACCAATATCGTGGATGTCTATATCCGTTATCTACGTAGCAAGCTTGATGTAAAAGGTCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6M9F7A8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.696

100

0.489
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.491

99.563

0.463

Multiple sequence alignment