Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   E3S71_RS00460 Genome accession   NZ_CP047852
Coordinates   83003..83632 (+) Length   209 a.a.
NCBI ID   WP_000153531.1    Uniprot ID   A0A481NSN8
Organism   Staphylococcus aureus strain UP_274     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 78003..88632
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3S71_RS00435 (E3S71_00435) - 78438..79424 (-) 987 WP_000999720.1 FUSC family protein -
  E3S71_RS00440 (E3S71_00440) map 79896..80654 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  E3S71_RS00445 (E3S71_00445) - 80871..81257 (+) 387 WP_001110179.1 hypothetical protein -
  E3S71_RS00450 (E3S71_00450) liaF 81272..81973 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  E3S71_RS00455 (E3S71_00455) vraS 81970..83013 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  E3S71_RS00460 (E3S71_00460) vraR 83003..83632 (+) 630 WP_000153531.1 two-component system response regulator VraR Regulator
  E3S71_RS00465 (E3S71_00465) - 83744..84961 (-) 1218 WP_000037079.1 YihY/virulence factor BrkB family protein -
  E3S71_RS00470 (E3S71_00470) - 85239..85514 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  E3S71_RS00475 (E3S71_00475) - 85521..85985 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  E3S71_RS00480 (E3S71_00480) - 86132..86332 (+) 201 WP_000180460.1 DUF1128 family protein -
  E3S71_RS00485 (E3S71_00485) - 86335..87591 (+) 1257 WP_001789555.1 aminopeptidase -
  E3S71_RS00490 (E3S71_00490) - 87680..88210 (+) 531 WP_000184383.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23471.17 Da        Isoelectric Point: 5.1621

>NTDB_id=417829 E3S71_RS00460 WP_000153531.1 83003..83632(+) (vraR) [Staphylococcus aureus strain UP_274]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVHKTSSGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=417829 E3S71_RS00460 WP_000153531.1 83003..83632(+) (vraR) [Staphylococcus aureus strain UP_274]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCATAAAACTTCTAGCGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSN8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.043

100

0.99
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment